Adjusting biomaterial composition to achieve controlled multiple-day release of dexamethasone from an extended-wear silicone hydrogel contact lens.

doi:10.1080/09205063.2013.840228

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Adjusting biomaterial composition to achieve controlled multiple-day release of dexamethasone from an extended-wear silicone hydrogel contact lens.

Journal Article•DOI•

Adjusting biomaterial composition to achieve controlled multiple-day release of dexamethasone from an extended-wear silicone hydrogel contact lens.

James C. Kaczmarek¹, Arianna Tieppo¹, Charles J. White¹, Mark E. Byrne¹•Institutions (1)

Auburn University¹

01 Jan 2014-Journal of Biomaterials Science-polymer Edition (J Biomater Sci Polym Ed)-Vol. 25, Iss: 1, pp 88-100

TL;DR: Based on the results, the lenses described herein likely have too high of a modulus for use as extended-wear, soft contact lenses with drug release, and other controlled release methods would be better suited for maintaining adequate mechanical properties and achieving controlled and extended release for the duration of wear in soft, silicone hydrogel contact lens biomaterials.

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Abstract: Purpose: To alter the composition and structure of silicone hydrogel contact lenses to achieve controlled release of dexamethasone and evaluate the lens optical and mechanical properties compared to commercial lenses. There is a tremendous need for controlled release of drugs from ocular biomaterials as the majority of ophthalmic drugs are delivered via topical eye drops, which have low bioavailability and patient compliance.Methods: Poly(PDMS-co-TRIS-co-DMA) contact lenses were synthesized with varying PDMS/TRIS:DMA ratios (0.25:1, 0.67:1, 1.5:1) as well as with additional crosslinking monomers. Lenses were characterized via in vitro release studies in a microfluidic device at ocular flowrates and in large well-mixed volumes, optical quality studies over visible wavelengths, mechanical analysis, and determination of polymer volume fraction in the swollen state.Results: Extended and controlled release of therapeutically relevant concentrations of dexamethasone was achieved for multiple day, continuous wea...

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Mechanically resilient, injectable, and bioadhesive supramolecular gelatin hydrogels crosslinked by weak host-guest interactions assist cell infiltration and in situ tissue regeneration

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Qian Feng¹, Kongchang Wei¹, Sien Lin¹, Zhen Xu², Yuxin Sun¹, Peng Shi², Gang Li¹, Liming Bian - Show less +4 more•Institutions (2)

The Chinese University of Hong Kong¹, City University of Hong Kong²

01 Sep 2016-Biomaterials

TL;DR: A facile supramolecular approach for preparing gelatin hydrogels with a wide array of desirable properties that are capable of sustaining excessive compressive and tensile strain and capable of quick self healing after mechanical disruption is described.

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223 citations

Cites background from "Adjusting biomaterial composition t..."

...However, these hydrophobic small molecules are difficult to be effectively loaded in the conventional hydrophic hydrogel network with a sustained long term release [36,37]....
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Journal Article•DOI•

3D printed drug delivery and testing systems - a passing fad or the future?

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Seng Han Lim¹, Himanshu Kathuria¹, Justin J. Y. Tan¹, Lifeng Kang²•Institutions (2)

National University of Singapore¹, University of Sydney²

01 Jul 2018-Advanced Drug Delivery Reviews

TL;DR: An overview of the advantages and limitations of 3D printing for drug delivery and testing, as compared to traditional manufacturing techniques is provided.

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Imprinted Contact Lenses for Sustained Release of Polymyxin B and Related Antimicrobial Peptides

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Negin Malakooti¹, Negin Malakooti², Cameron Alexander¹, Carmen Alvarez-Lorenzo²•Institutions (2)

University of Nottingham¹, University of Santiago de Compostela²

01 Oct 2015-Journal of Pharmaceutical Sciences

TL;DR: Microbiological assays carried out with Pseudomonas aeruginosa allowed identification of the most suitable hydrogel composition for efficient bacteria eradication; some hydrogels being able to stand several continued challenges against this important bacterial pathogen.

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73 citations

Cites background from "Adjusting biomaterial composition t..."

...Therefore, the design of drug-contact lens combination products requires an adequate match of the chemical functionalities of the contact lens network with those of the drug to be delivered, while preserving the unique light transparency and oxygen permeability of the contact lenses.(10,11)....
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Journal Article•DOI•

Superadsorbent with three-dimensional networks: From bulk hydrogel to granular hydrogel

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Yian Zheng¹, Yian Zheng², Aiqin Wang¹•Institutions (2)

Chinese Academy of Sciences¹, Lanzhou University²

01 Nov 2015-European Polymer Journal

TL;DR: In this article, the focus of polymerization strategies for the formation of granular hydrogels, with the scope limited to the crosslinked hydrogel via polymerization using one or more vinyl monomers.

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60 citations

Journal Article•DOI•

Release of Ciprofloxacin and Moxifloxacin From Daily Disposable Contact Lenses From an In Vitro Eye Model.

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Magdalena Bajgrowicz¹, Chau-Minh Phan², Lakshman N. Subbaraman², Lyndon Jones²•Institutions (2)

Wrocław University of Technology¹, Vision-Sciences, Inc.²

01 Apr 2015-Investigative Ophthalmology & Visual Science

TL;DR: The parameters of the release system, in particular the volume and flow rate, have a significant influence on measured release profiles, and under physiological flow, release profiles are significantly slower and constant when compared with release in a vial.

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Abstract: Bajgrowicz, M., Phan, C.-M., Subbaraman, L. N., & Jones, L. (2015). Release of Ciprofloxacin and Moxifloxacin From Daily Disposable Contact Lenses From an In Vitro Eye Model. Investigative Opthalmology & Visual Science, 56(4), 2234. https://doi.org/10.1167/iovs.15-16379

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44 citations

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Journal Article•DOI•

Soft contact lens polymers: an evolution

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Paul Clement Nicolson¹, Jürgen Vogt¹•Institutions (1)

Ciba Specialty Chemicals¹

15 Dec 2001-Biomaterials

TL;DR: A review of patents and literature reveals an evolution in materials technologies driven by an increased understanding of the physiological needs of the cornea, beginning with the first hydrogel lenses developed by Wichterle, followed by a variety of high water hydrogels.

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675 citations

Journal Article•DOI•

Episcleritis and scleritis: clinical features and treatment results.

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Douglas A. Jabs¹, Abdulbaki Mudun¹, James P. Dunn¹, Marta J. Marsh¹•Institutions (1)

Johns Hopkins University School of Medicine¹

01 Oct 2000-American Journal of Ophthalmology

TL;DR: Nearly 60% of patients with scleral inflammation will need oral corticosteroids or immunosuppressive drugs to control the disease, and nearly always treated with systemic medications.

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309 citations

"Adjusting biomaterial composition t..." refers background in this paper

...[13] Untreated ocular inflammation can frequently lead to pain, photophobia, and more serious issues such as interstitial keratitis.[14] Journal of Biomaterials Science, Polymer Edition 89...
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Journal Article•DOI•

A study of the causes of non-compliance by patients prescribed eyedrops.

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A. J. Winfield, D. Jessiman, A. Williams, L. Esakowitz

01 Aug 1990-British Journal of Ophthalmology

TL;DR: An investigation into the causes of non-compliance by patients using eyedrops has been undertaken by questionnaire, ability tests, and by tests on eyedrop bottles, indicating a high prevalence ofNon-compliance, compounded by an inability adequately to instill a drop into the eye.

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Abstract: An investigation into the causes of non-compliance by patients using eyedrops has been undertaken by questionnaire, ability tests, and by tests on eyedrop bottles. The results indicate a high prevalence of non-compliance, compounded by an inability adequately to instill a drop into the eye. About half the patients had difficulty aiming the drop, and other problems including squeezing the bottle, blinking, and seeing the tip of the bottle. Ability tests included a measurement of the grip strength of patients to complement measurement of the force required to expel a drop from a bottle. Some patients, particularly those with arthritis, could not generate enough force to squeeze a bottle. These same patients also had difficulty with the other movements required to administer drops. While some attempts have been made to produce devices to assist with eyedrops which can improve the aim of the patient, none give assistance in expelling a drop. An additional problem found was the reluctance of patients to admit to medical staff that they experienced any difficulty with their drops.

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285 citations

"Adjusting biomaterial composition t..." refers background in this paper

...One study showed that over a 30-day period, 41% of patients missed six or more of their eye drop doses, while another study showed that over 50% of patients missed 20% of their doses.[3] Such low patient compliance leads to a substantially higher risk of ocular complications and disease....
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Journal Article•DOI•

A study of the evolution of mechanical properties and structural heterogeneity of polymer networks formed by photopolymerizations of multifunctional (meth)acrylates

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Anandkumar R. Kannurpatti¹, Jay W. Anseth², Christopher N. Bowman²•Institutions (2)

Wilmington University¹, University of Colorado Boulder²

01 Jan 1998-Polymer

TL;DR: In this paper, a study of the mechanical properties and structural heterogeneity of crosslinked polymers formed by photopolymerization of multifunctional monomers is described. But the results indicate that the structural heterogeneity increases as the crosslinking density of the copolymer is increased.

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275 citations

"Adjusting biomaterial composition t..." refers background in this paper

...It has been previously demonstrated in acrylate polymers that adjusting the co-monomer composition significantly influences the mechanical properties, such as modulus and glass transition temperature.[12] In this study, the ratio of hydrophobic to hydrophilic co-monomer composition and network structure of silicone hydrogel contact lens biomaterials are rationally altered to control the release of the hydrophobic steroid, dexamethasone....
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Journal Article•DOI•

In vitro uptake and release studies of ocular pharmaceutical agents by silicon-containing and p-HEMA hydrogel contact lens materials

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Caroline Karlgard¹, N S Wong¹, N S Wong², Lyndon Jones¹, Christine Moresoli¹ - Show less +1 more•Institutions (2)

University of Waterloo¹, McGill University²

12 May 2003-International Journal of Pharmaceutics

TL;DR: The in vitro uptake and release behaviour of cromolyn sodium, ketotifen fumarate, ketorolac tromethamine and dexamethasone sodium phosphate with silicon-containing and p-HEMA-containing hydrogel contact lenses indicated that both drug and material affected the uptake andrelease behaviour.

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255 citations

"Adjusting biomaterial composition t..." refers background in this paper

...[9] However, poor loading and lack of control over release has led to very little success with this strategy.[10,11] Surprisingly, little work has been done tailoring the rate of drug release from silicone hydrogel contact lens biomaterials by altering the lens composition and network structure while maintaining sufficient optical and mechanical properties for clinical use....
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