Adrenomedullin: A Novel Therapeutic for the Treatment of Inflammatory Bowel Disease
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Adrenomedullin (AM) is a bioactive peptide with various physiological functions, including vasodilation, angiogenesis, anti-inflammation, organ protection, and tissue repair as mentioned in this paper.Abstract:
Adrenomedullin (AM) is a bioactive peptide with various physiological functions, including vasodilation, angiogenesis, anti-inflammation, organ protection, and tissue repair. AM suppresses inflammatory cytokine production in the intestinal mucosa, improves vascular and lymphatic regeneration and function, mucosal epithelial repair, and immune function in the intestinal bacteria of animal models with intestinal inflammation. We have been promoting translational research to develop novel therapeutic agents for inflammatory bowel disease (IBD) using AM and have started clinical research for IBD patients since 2010. A multicenter clinical trial is currently underway in Japan for patients with refractory ulcerative colitis and Crohn's disease. Moreover, since current AM administration is limited to continuous intravenous infusion, the development of a subcutaneous formulation using long-acting AM is underway for outpatient treatment.read more
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Translational studies of adrenomedullin and related peptides regarding cardiovascular diseases
Toshihiro Kita,Kazuo Kitamura +1 more
TL;DR: Adrenomedullin (AM) is a vasodilative peptide with various physiological functions, including the maintenance of vascular tone and endothelial barrier function, which is a useful clinical marker and therapeutic agent for inflammation as discussed by the authors .
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Adrenomedullin ameliorates palmitic acid-induced insulin resistance through PI3K/Akt pathway in adipocytes
TL;DR: This study demonstrates a prevention potential of ADM against obesity-related metabolic disorders, due to its protective effects against IR, inflammation and oxidative stress in adipocytes.
Journal ArticleDOI
Adrenomedullin: Not Just Another Gastrointestinal Peptide
TL;DR: AM is a key protective factor in IBD onset and development, as it regulates cytokine production in the intestinal mucosa, improves vascular and lymphatic regeneration and function and mucosal epithelial repair, and promotes a beneficial gut microbiome composition.
Journal ArticleDOI
Elucidating the Interactome of G Protein-Coupled Receptors and Receptor Activity-Modifying Proteins
TL;DR: A review of recent advances in techniques that allow the discovery of GPCR-RAMP interactions and their functional consequences and highlight prospects for future advances can be found in this paper , where the authors also provide an up-to-date list of reported G protein-coupled receptor (GPCR)-RAMP interaction based on a review of the current literature.
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Beyond depression and anxiety; a systematic review about the role of corticotropin-releasing hormone antagonists in diseases of the pelvic and abdominal organs
Joshua E. Pagán-Busigó,Jonathan López-Carrasquillo,Caroline B. Appleyard,Annelyn Torres-Reveron +3 more
TL;DR: There is evidence for their beneficial effects beyond mood disorders, but future pre-clinical studies should be tailored towards effectively predicting the clinical scenario, including reduction of bias and randomization.
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TL;DR: Occurrence of adrenomedullin indicates the possible existence of a novel system for circulation control and suggests that adrenomed Mullin is a new hormone participating in blood pressure control.
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The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017
Sudabeh Alatab,Sadaf G. Sepanlou,Kevin Ikuta,Homayoon Vahedi,Catherine Bisignano,Saeid Safiri,Anahita Sadeghi,Molly R Nixon,Amir Abdoli,Hassan Abolhassani,Vahid Alipour,Majid A Almadi,Amir Almasi-Hashiani,Amir Anushiravani,Jalal Arabloo,Suleman Atique,Ashish Awasthi,Alaa Badawi,Atif Amin Baig,Neeraj Bhala,Ali Bijani,Antonio Biondi,Antonio Maria Borzì,Kristin E Burke,Félix Carvalho,Ahmad Daryani,Manisha Dubey,Aziz Eftekhari,Eduarda Fernandes,João C. Fernandes,Florian Fischer,Arvin Haj-Mirzaian,Arya Haj-Mirzaian,Amir Hasanzadeh,Maryam Hashemian,Simon I. Hay,Chi L Hoang,Mowafa Househ,Olayinka Stephen Ilesanmi,Nader Jafari Balalami,Spencer L. James,Andre Pascal Kengne,Masoud M Malekzadeh,Shahin Merat,Tuomo J. Meretoja,Tomislav Mestrovic,Erkin M. Mirrakhimov,Hamid Reza Mirzaei,Karzan Abdulmuhsin Mohammad,Ali H. Mokdad,Lorenzo Monasta,Ionut Negoi,Trang Huyen Nguyen,Cuong Tat Nguyen,Akram Pourshams,Hossein Poustchi,Mohammad Rabiee,Navid Rabiee,Kiana Ramezanzadeh,David Laith Rawaf,Salman Rawaf,Nima Rezaei,Stephen R. Robinson,Luca Ronfani,Sonia Saxena,Masood Sepehrimanesh,Masood Ali Shaikh,Zeinab Sharafi,Mehdi Sharif,Soraya Siabani,Ali Reza Sima,Jasvinder A. Singh,Amin Soheili,Rasoul Sotoudehmanesh,Hafiz Ansar Rasul Suleria,Berhe Etsay Tesfay,Bach Xuan Tran,Derrick Tsoi,Marco Vacante,Adam Belay Wondmieneh,Afshin Zarghi,Zhi-Jiang Zhang,Mae Dirac,Reza Malekzadeh,Mohsen Naghavi +84 more
TL;DR: The prevalence of IBD increased substantially in many regions from 1990 to 2017, which might pose a substantial social and economic burden on governments and health systems in the coming years.
Journal ArticleDOI
Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells
Koji Atarashi,Takeshi Tanoue,Minoru Ando,Nobuhiko Kamada,Yuji Nagano,Seiko Narushima,Wataru Suda,Wataru Suda,Akemi Imaoka,Hiromi Setoyama,Takashi Nagamori,Eiji Ishikawa,Tatsuichiro Shima,Taeko Hara,Shoichi Kado,Toshi Jinnohara,Hiroshi Ohno,Takashi Kondo,Kiminori Toyooka,Eiichiro Watanabe,Shin ichiro Yokoyama,Shunji Tokoro,Hiroshi Mori,Yurika Noguchi,Hidetoshi Morita,Ivaylo I. Ivanov,Tsuyoshi Sugiyama,Gabriel Núñez,J. Gray Camp,Masahira Hattori,Masahira Hattori,Yoshinori Umesaki,Kenya Honda +32 more
TL;DR: It is shown that adhesion of microbes to intestinal epithelial cells (ECs) is a critical cue for Th17 induction, and a mixture of 20 bacterial strains, which were selected and isolated from fecal samples of a patient with ulcerative colitis on the basis of their ability to cause a robust induction of Th17 cells in the mouse colon, exhibited EC-adhesive characteristics.