Journal ArticleDOI
Adult eczema prevalence and associations with asthma and other health and demographic factors: A US population–based study
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TLDR
The results suggest multiple demographic and socioeconomic influences on the US prevalence of adult eczema may be influenced by Hispanic ethnicity, US birthplace, and higher level of household education.Abstract:
Background Little is known about the epidemiology of eczema in adults. The goal of this study was to determine the prevalence of and associations with adult eczema in the United States. Methods We used the 2010 National Health Interview Survey from a nationally representative sample of 27,157 adults age 18 to 85 years. Results Overall, the 1-year prevalence of eczema was 10.2% (95% CI, 9.7% to 10.6%). The 1-year prevalence of eczema with asthma and/or hay fever was 3.2% (95% CI, 2.8% to 3.3%). Adult eczema was associated with higher prevalence of asthma ( P 2 test), more asthma attacks in the past year ( P P = .02). In multivariate models eczema prevalence was significantly higher in older participants; female subjects; those with Hispanic ethnicity, US birthplace, and higher level of household education; and those currently working (all P ≤ .02, logistic regression). Conclusions This study provides US population–based estimates of eczema prevalence and asthma associations in adults. The results suggest multiple demographic and socioeconomic influences on the US prevalence of adult eczema.read more
Citations
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Long-term management of moderate-to-severe atopic dermatitis with dupilumab and concomitant topical corticosteroids (LIBERTY AD CHRONOS): a 1-year, randomised, double-blinded, placebo-controlled, phase 3 trial
Andrew Blauvelt,Marjolein S. de Bruin-Weller,Melinda Gooderham,Jennifer Clay Cather,Jamie Weisman,David M. Pariser,Eric L. Simpson,Kim A. Papp,H. Chih ho Hong,Diana Rubel,Peter Foley,Errol P. Prens,Christopher E.M. Griffiths,Takafumi Etoh,Pedro Herranz Pinto,Ramon M. Pujol,Jacek C Szepietowski,Karel Ettler,Lajos Kemény,Xiaoping Zhu,Bolanle Akinlade,Thomas Hultsch,Vera Mastey,Abhijit Gadkari,Laurent Eckert,Nikhil Amin,Neil M.H. Graham,Gianluca Pirozzi,Neil Stahl,George D. Yancopoulos,Brad Shumel +30 more
TL;DR: This 1-year, randomised, double-blinded, placebo-controlled, phase 3 study aimed to evaluate the long-term efficacy and safety of dupilumab with medium-potency topical corticosteroids versus placebo with topical cortiosteroids in adults with moderate-to-severe atopic dermatitis.
Journal ArticleDOI
The Atopic March: Progression from Atopic Dermatitis to Allergic Rhinitis and Asthma.
TL;DR: Recent studies support the idea of a causal link between AD and later onset atopic disorders and suggest that a dysfunctional skin barrier serves as a site for allergic sensitization to antigen and colonization of bacterial super antigens.
Journal ArticleDOI
Efficacy and safety of dupilumab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments: a randomised, placebo-controlled, dose-ranging phase 2b trial.
Diamant Thaçi,Eric L. Simpson,Lisa A. Beck,Thomas Bieber,Andrew Blauvelt,Kim A. Papp,Weily Soong,Margitta Worm,Jacek C Szepietowski,Howard Sofen,M. Kawashima,Richard Wu,Steven P. Weinstein,Neil M.H. Graham,Gianluca Pirozzi,Ariel Teper,E. Rand Sutherland,Vera Mastey,Neil Stahl,George D. Yancopoulos,Marius Ardeleanu +20 more
TL;DR: Dupilumab improved clinical responses in adults with moderate-to-severe atopic dermatitis in a dose-dependent manner, without significant safety concerns, and shows that IL-4 and IL-13 are key drivers of atopic skinitis.
Journal ArticleDOI
Epidemiology of atopic dermatitis in adults: Results from an international survey.
Sébastien Barbarot,S. Auziere,Abhijit Gadkari,Giampiero Girolomoni,Lluís Puig,Eric L. Simpson,David J. Margolis,M S de Bruin-Weller,Laurent Eckert +8 more
TL;DR: There are gaps in the authors' knowledge of the prevalence of adult atopic dermatitis (AD) and the need to investigate these gaps more fully.
Journal ArticleDOI
Cellular and molecular immunologic mechanisms in patients with atopic dermatitis
Thomas Werfel,Jean-Pierre Allam,Tilo Biedermann,Kilian Eyerich,Stefanie Gilles,Emma Guttman-Yassky,Wolfram Hoetzenecker,Edward F. Knol,Hans-Uwe Simon,Andreas Wollenberg,Thomas Bieber,Roger Lauener,Peter Schmid-Grendelmeier,Claudia Traidl-Hoffmann,Cezmi A. Akdis +14 more
TL;DR: Best evidence of the clinical efficacy of novel immunologic approaches using biological agents in patients with AD is available for the anti-IL-4 receptor α-chain antibody dupilumab, but a number of studies are currently ongoing with other specific antagonists to immune system players.
References
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Yoav Benjamini,Yosef Hochberg +1 more
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Sabina Illi,Erika von Mutius,Susanne Lau,Renate Nickel,Christoph Grüber,Bodo Niggemann,Ulrich Wahn +6 more
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Journal ArticleDOI
Eczema Prevalence in the United States: Data from the 2003 National Survey of Children's Health
TL;DR: Prevalence ranged from 8.7 to 18.1% between states and districts, with the highest prevalence reported in many of the East Coast states, as well as in Nevada, Utah, and Idaho.
Journal ArticleDOI
Investigating international time trends in the incidence and prevalence of atopic eczema 1990-2010: a systematic review of epidemiological studies.
Ivette A. G. Deckers,Ivette A. G. Deckers,Susannah McLean,Sanne Linssen,Monique Mommers,C.P. van Schayck,Aziz Sheikh,Aziz Sheikh +7 more
TL;DR: A systematic search for high quality reports of cohort, repeated cross-sectional and routine healthcare database-based studies in seven electronic databases found evidence suggesting that the prevalence of atopic eczema was increasing in Africa, eastern Asia, western Europe and parts of northern Europe.
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Update on risk factors for food allergy.
TL;DR: An alternative hypothesis is proposed, suggesting that early cutaneous Exposure to food protein through a disrupted skin barrier leads to allergic sensitization and that early oral exposure to food allergen induces tolerance.
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