Adult male rat hippocampus synthesizes estradiol from pregnenolone by cytochromes P45017α and P450 aromatase localized in neurons
Citations
1,665 citations
866 citations
Cites background from "Adult male rat hippocampus synthesi..."
...strogen synthesis (32) and estrogen receptor messenger RNA mRNA) have been localized to the hippocampus (33,34), hereas androgen receptors are more prevalent in the amygdala 35) (see 36 for further discussion on estrogen receptor distribuion and the relationship to psychiatry)....
[...]
848 citations
804 citations
759 citations
Cites background from "Adult male rat hippocampus synthesi..."
...The de novo (from cholesterol) synthesis of estradiol in the avian brain is well established (97, 188) and has recently been reported for the mammalian hippocampus as well (96, 171)....
[...]
...A critical enzyme, CYP17, required for the conversion of pregnenolone to DHEA had long eluded detection in the adult brain, despite measurable levels of DHEA, until a recent report detecting it in adult male hippocampus (96)....
[...]
References
680 citations
665 citations
636 citations
622 citations
496 citations