Advances, gaps and opportunities in the detection of familial hypercholesterolemia: overview of current and future screening and detection methods.
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Cites background from "Advances, gaps and opportunities in..."
...of reasons for underdiagnosis of FH, including lack of systematic cholesterol screening in children and adults and a lack of awareness about FH among healthcare clinicians [5-8]....
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References
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"Advances, gaps and opportunities in..." refers background in this paper
...acterized by life-long elevation of LDL cholesterol (LDL-C), resulting in an up to 25-fold higher atherosclerotic cardiovascular disease (ASCVD) risk in familial hypercholesterolemia patients compared with individuals with normal LDL-C levels [1]....
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581 citations
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...In children, phenotypic diagnosis of familial hypercholesterolemia is based on an LDL-C of at least 5 mmol/l, or an LDL-C of at least 4 mmol/l with family history of premature CAD and/or high baseline cholesterol in one parent [14]....
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...The applicability of current diagnostic tools in children varies; the DLCN criteria are not valid in children, while the Simon Broome criteria have specific LDL-C cut-offs with an LDL-C threshold of 4 mmol/l in children with familial hypercholesterolemia aged less than 10 years [14]....
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500 citations
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...The American Heart Association (AHA) criteria define a similar clinical classification of familial hypercholesterolemia [19], whereby heterozygous familial hypercholesterolemia is defined as a positive family history of elevated cholesterol or premature CAD and LDL-C of at least 4 mmol/l in a child or at least 5 mmol/l in an adult confirmed on two occasions [19]....
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439 citations
"Advances, gaps and opportunities in..." refers background in this paper
...6. deGoma EM, Ahmad ZS, O’Brien EC, et al. Treatment gaps in adults with heterozygous familial hypercholesterolemia in the United States: data from the CASCADE-FH Registry....
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...The American Heart Association (AHA) criteria define a similar clinical classification of familial hypercholesterolemia [19], whereby heterozygous familial hypercholesterolemia is defined as a positive family history of elevated cholesterol or premature CAD and LDL-C of at least 4 mmol/l in a child or at least 5 mmol/l in an adult confirmed on two occasions [19]....
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...Patients admitted to the CCU with ACS or previously documented CAD should be routinely screened for familial hypercholesterolemia after Copyright © 2020 Wolters Kluwer H 350 www.co-lipidology.com which cascade testing of relatives should be initiated....
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...Familial hypercholesterolemia is the most common monogenic cause of premature coronary artery disease (CAD)....
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...Source of data: Dutch national expertise ce from [55,58]....
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