Advances in orodispersible films for drug delivery.
Citations
332 citations
Cites background from "Advances in orodispersible films fo..."
...Orodispersible films should not be misunderstood with buccal films designed for staying longer on the cheek mucosa [24]....
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206 citations
178 citations
Cites background from "Advances in orodispersible films fo..."
...The use of milk as a vehicle for the administration of drugs was also at the background of the development of a ‘nipple shield’ delivery system (Figure 2), which is designed to accommodate a drug-loaded insert delivering the API into milk while breastfeeding neonates [20,21]....
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...For this reason, the time required to achieve complete dissolution of the API should be determined and stated in the product label....
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...Preferably, ODFs should be sealed individually in order to improve stability and reduce the risk of overdosing due to films sticking together [74]....
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...This can be achieved by simply combining multiparticulates with different APIs and/or different release characteristics into the same dosage form, respectively....
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...Thus flexible technology platforms are desired enabling the preparation of formulations with different active pharmaceutical ingredients (APIs), dose strengths and/or release profiles [1,10]....
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177 citations
Cites background from "Advances in orodispersible films fo..."
...Gastrointestinal disease is the name given to all of those diseases that damage the digestive system (esophagus, stomach, small intestine, large intestine and rectum, and the accessory organs of digestion: liver, gallbladder, and pancreas) [55]....
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175 citations
Cites background from "Advances in orodispersible films fo..."
...The casted films are cut into suitable sizes for oral administration (e.g. 2 4 cm) and sealed in moisture-protecting packages (Hoffmann et al., 2011)....
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References
653 citations
"Advances in orodispersible films fo..." refers background in this paper
...Oral mucosa is described in detail elsewhere [62,73,74,81]....
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...The permeability of the oral mucosa decreases in the order sublingual to buccal to palatal [74]....
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...For the development of sustained-release films or oral patches, some tests on bioadhesion can be helpful [22,55,62,73,74]....
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...Usually mucosal tissue from animals is used as surrogates for human mucosa, for example, porcine mucosa [62,73,74]....
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539 citations
"Advances in orodispersible films fo..." refers background in this paper
...A residual water content is necessary to obtain flexible films [19]....
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...Natural gums such as xanthan or guar gum can improve viscosity and film-forming capacity [19,20,42]....
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...De-aeration of the coating mass is achieved by continuous stirring and application of a vacuum [1,19]....
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...The end point of drying has to be controlled carefully [19,27]....
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...If the drug is absorbed through the oral mucosa, first-pass metabolism can be avoided for some drugs, which may improve bioavailability [18,19]....
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476 citations
"Advances in orodispersible films fo..." refers methods in this paper
...developed a disintegration test for orodispersible tablets using a modified dissolution apparatus, which might work for ODFs as well, although an unphysiologically high volume of dissolution medium is applied [69]....
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454 citations
386 citations