Age as a Confounding Factor for the Accurate Non-Invasive Diagnosis of Advanced NAFLD Fibrosis
01 May 2017-The American Journal of Gastroenterology (Nature Publishing Group)-Vol. 112, Iss: 5, pp 740-751
TL;DR: The NFS and FIB-4 scores have similar accuracy for advanced fibrosis in patients aged >35 years, however, the specificity forAdvanced fibrosis is unacceptably low in patients ages aged ≥65 years, resulting in a high false positive rate.
About: This article is published in The American Journal of Gastroenterology.The article was published on 2017-05-01 and is currently open access. It has received 463 citations till now. The article focuses on the topics: Confounding.
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TL;DR: Experts reached consensus that NAFLD does not reflect current knowledge and metabolic (dysfunction) associated fatty liver disease "MAFLD" was suggested as a more appropriate overarching term and opens the door for efforts from the research community to update the nomenclature and sub-phenotype the disease in order to accelerate the translational path to new treatments.
1,544 citations
Newcastle University1, Hannover Medical School2, University of Palermo3, Saga University4, University of Würzburg5, Istituto Superiore di Sanità6, RWTH Aachen University7, University of Barcelona8, University of California, San Diego9, Yokohama City University10, French Institute of Health and Medical Research11, VCU Medical Center12, University of Mainz13, Hiroshima University14, Peking University15, Goethe University Frankfurt16
TL;DR: NAFLD and NASH represent a large and growing public health problem and efforts to understand this epidemic and to mitigate the disease burden are needed, if obesity and DM continue to increase at current and historical rates.
973 citations
TL;DR: The current state of the noninvasive assessment of liver disease in NAFLD is summarized, and an expert synthesis of how these nonin invasive tools could be utilized in clinical practice is provided.
780 citations
TL;DR: MRE and SWE may have the highest diagnostic accuracy for staging fibrosis in NAFLD patients, and among the four noninvasive simple indexes, NFS and FIB‐4 probably offer the best diagnostic performance for detecting AF.
548 citations
Cites background from "Age as a Confounding Factor for the..."
...However, McPherson et al.((18)) reported that the occurrence rate of AF (stages 3-4) was higher in patients who were over 56 years of age and demonstrated that the ROC values of FIB-4 and NFS were greater than those of aspartate aminotransferase to alanine aminotransferase ratio for predicting fibrosis in NAFLD patients of different ages....
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...(17) However, McPherson et al.(18) reported that the occurrence rate of AF (stages 3-4) was higher in patients who were over 56 years of age and demonstrated that the ROC values of FIB-4 and NFS were greater than those of aspartate aminotransferase to alanine aminotransferase ratio for predicting fibrosis in NAFLD patients of different ages....
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TL;DR: An update is provided on the epidemiology, clinical and prognostic features, and diagnostic approach to patients with NAFLD, with a view to targeting resources to those who need it most.
524 citations
References
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TL;DR: The chronic hyperglycemia of diabetes is associated with long-term damage, dys-function, and failure of differentorgans, especially the eyes, kidneys, nerves, heart, and blood vessels.
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TL;DR: A strong scoring system and NAS for NAFLD and NASH with reasonable inter‐rater reproducibility that should be useful for studies of both adults and children with any degree ofNAFLD are presented.
8,253 citations
TL;DR: The prevalence of hepatic steatosis was greater in men than women among whites, but not in blacks or Hispanics, and significant ethnic and sex differences in the prevalence may have a profound impact on susceptibility to Steatosis‐related liver disease.
3,429 citations
TL;DR: This is a practice guideline for clinicians rather than a review article and interested readers can refer to several comprehensive reviews published recently.
3,212 citations
TL;DR: In conclusion, noninvasive tests can accurately predict hepatic fibrosis and may reduce the need for liver biopsy in the majority of HIV/HCV‐coinfected patients.
3,183 citations