Journal ArticleDOI
Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia
Fulvio Lauretani,Cosimo Roberto Russo,Stefania Bandinelli,Benedetta Bartali,Chiara Cavazzini,Angelo Di Iorio,Anna Maria Corsi,Taina Rantanen,Jack M. Guralnik,Luigi Ferrucci +9 more
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TLDR
Optimal cutoff values that can be used in the clinical practice to identify older persons with poor mobility were developed and lay the basis for a cost-effective, clinical marker of sarcopenia based on a measure of isometric handgrip strength.Abstract:
Sarcopenia, the reduction of muscle mass and strength that occurs with aging, is widely considered one of the major causes of disability in older persons. Surprisingly, criteria that may help a clinician to identify persons with impaired muscle function are still lacking. Using data from a large representative sample of the general population, we examined how muscle function and calf muscle area change with aging and affect mobility in men and women free of neurological conditions. We tested several putative indicators of sarcopenia, including knee extension isometric torque, handgrip, lower extremity muscle power, and calf muscle area. For each indicator, sarcopenia was considered to be present when the measure was >2 SDs below the mean. For all four measures, the prevalence of sarcopenia increased with age, both in men and women. The age-associated gradient in prevalence was maximum for muscle power and minimum for calf-muscle area. However, lower extremity muscle power was no better than knee-extension torque or handgrip in the early identification of poor mobility, defined either as walking speed <0.8 m/s or inability to walk at least 1 km without difficulty and without developing symptoms. Optimal cutoff values that can be used in the clinical practice to identify older persons with poor mobility were developed. The findings of the study lay the basis for a cost-effective, clinical marker of sarcopenia based on a measure of isometric handgrip strength. Our findings should be verified in a longitudinal study.read more
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Sarcopenia: European consensus on definition and diagnosis Report of the European Working Group on Sarcopenia in Older People
Alfonso J. Cruz-Jentoft,Jean-Pierre Baeyens,Jürgen M. Bauer,Yves Boirie,Tommy Cederholm,Francesco Landi,Finbarr C. Martin,Jean-Pierre Michel,Yves Rolland,Stéphane M. Schneider,Eva Topinkova,Maurits Vandewoude,Mauro Zamboni +12 more
TL;DR: The European Working Group on Sarcopenia in Older People (EWGSOP) developed a practical clinical definition and consensus diagnostic criteria for age-related sarcopenia as discussed by the authors.
Journal ArticleDOI
Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia.
Roger A. Fielding,Bruno Vellas,William J. Evans,Shalender Bhasin,John E. Morley,Anne B. Newman,Gabor Abellan van Kan,Sandrine Andrieu,Juergen M. Bauer,Denis Breuille,Tommy Cederholm,Julie Chandler,Capucine De Meynard,Lorenzo M. Donini,Tamara B. Harris,Aimo Kannt,Florence Keime Guibert,Graziano Onder,Dimitris Papanicolaou,Yves Rolland,Daniel Rooks,Cornel C. Sieber,Elisabeth Souhami,Sjors Verlaan,Mauro Zamboni +24 more
TL;DR: Sarcopenia should be considered in all older patients who present with observed declines in physical function, strength, or overall health, and patients who meet these criteria should further undergo body composition assessment using dual energy x-ray absorptiometry with sarcopenia being defined using currently validated definitions.
Journal ArticleDOI
Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: a systematic review of cohort studies
Abel Romero-Corral,Victor M. Montori,Virend K. Somers,Josef Korinek,Randal J. Thomas,Thomas G. Allison,Farouk Mookadam,Francisco Lopez-Jimenez +7 more
TL;DR: The better outcomes for cardiovascular and total mortality seen in the overweight and mildly obese groups could not be explaining by adjustment for confounding factors and could be explained by the lack of discriminatory power of BMI to differentiate between body fat and lean mass.
Journal ArticleDOI
Sarcopenic obesity: definition, cause and consequences.
Sari Stenholm,Tamara B. Harris,Taina Rantanen,Marjolein Visser,Stephen B. Kritchevsky,Luigi Ferrucci +5 more
TL;DR: It is proposed that the risk of adverse outcomes, such as functional limitation and mortality, is better estimated by considering jointly obesity and muscle strength rather than Obesity and muscle mass and the term ‘sarcopenic obesity’ should be revisited.
Journal ArticleDOI
Sarcopenia: Its assessment, etiology, pathogenesis, consequences and future perspectives
Yves Rolland,Stefan A. Czerwinski,G. Abellan Van Kan,John E. Morley,Matteo Cesari,Graziano Onder,Jean Woo,Richard N. Baumgartner,Fabien Pillard,Yves Boirie,Wm. Cameron Chumlea,Bruno Vellas +11 more
TL;DR: On-going and future clinical trials on sarcopenia may radically change the authors' preventive and therapeutic approaches of mobility disability in older people.
References
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Journal ArticleDOI
The meaning and use of the area under a receiver operating characteristic (ROC) curve.
TL;DR: A representation and interpretation of the area under a receiver operating characteristic (ROC) curve obtained by the "rating" method, or by mathematical predictions based on patient characteristics, is presented and it is shown that in such a setting the area represents the probability that a randomly chosen diseased subject is (correctly) rated or ranked with greater suspicion than a random chosen non-diseased subject.
Journal ArticleDOI
Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach.
TL;DR: A nonparametric approach to the analysis of areas under correlated ROC curves is presented, by using the theory on generalized U-statistics to generate an estimated covariance matrix.
Journal ArticleDOI
Epidemiology of Sarcopenia among the Elderly in New Mexico
Richard N. Baumgartner,Kathleen M. Koehler,Dympna Gallagher,Linda J. Romero,Steven B. Heymsfield,Robert Ross,Philip J. Garry,Robert D. Lindeman +7 more
TL;DR: Some of the first estimates of the extent of the public health problem posed by sarcopenia are provided, independent of ethnicity, age, morbidity, obesity, income, and health behaviors.
Journal ArticleDOI
Lower-Extremity Function in Persons over the Age of 70 Years as a Predictor of Subsequent Disability
TL;DR: Among nondisabled older persons living in the community, objective measures of lower-extremity function were highly predictive of subsequent disability.
Journal ArticleDOI
Lower Extremity Function and Subsequent Disability Consistency Across Studies, Predictive Models, and Value of Gait Speed Alone Compared With the Short Physical Performance Battery
Jack M. Guralnik,Luigi Ferrucci,Carl F. Pieper,Suzanne G. Leveille,Kyriakos S. Markides,Glenn V. Ostir,Stephanie A. Studenski,Lisa F. Berkman,Robert B. Wallace +8 more
TL;DR: Performance tests of lower extremity function accurately predict disability across diverse populations and Equations derived from models using both the summary score and the gait speed alone allow for the estimation of risk of disability in community-dwelling populations and provide valuable information for estimating sample size for clinical trials of disability prevention.