Age-related Changes in Bone Marrow Mesenchymal Stromal Cells: A Potential Impact on Osteoporosis and Osteoarthritis Development
Citations
295 citations
231 citations
201 citations
116 citations
116 citations
References
9,980 citations
7,917 citations
"Age-related Changes in Bone Marrow ..." refers background in this paper
...The FR theory or the theory of ROS proposes that the continuous process of FR generation in metabolism causes damages to tissues owing to the presence of free and unpaired electron on the oxygen atomic outer shell.(17) Antioxidants in the body combat the negative effects of ROS....
[...]
2,949 citations
"Age-related Changes in Bone Marrow ..." refers background in this paper
...The stem cell niche is commonly defined as an in vivo regulatory microenvironment where stem cells reside.(63) MSC niches in human BM are poorly understood but are believed to be primarily in the perivascular and bone-lining locations....
[...]
1,704 citations
"Age-related Changes in Bone Marrow ..." refers background in this paper
...The significant drop of sex hormone levels and the increase of the glucocorticoids production and activity are hormonal hallmarks of human aging that are associated with reduced bone mass.(69,70) The functional capacities of MSCs have been linked to these age-related hormones....
[...]
1,504 citations
"Age-related Changes in Bone Marrow ..." refers background in this paper
...Considering that MSCs form an integral part of the musculoskeletal system and that OP and OA have been associated with aging,1,3 prevention of MSC aging in vivo could lead to novel therapies to target altered bone formation in OP and OA....
[...]
...Increase in age is one of the risk factors for OA.3 However, it is now 1 Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom 2 Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds, United Kingdom...
[...]
...Abdallah et al. tested the impact of serum from young (20–30 years old) and old (70–84 years old) donors on MSC differentiation and proliferation and found a significant decline in osteogenic differentiation potential of MSCs grown in serum from old donors.87 This suggests the existence of, yet unknown, factors in the serum or plasma from “younger” donors that could potentially be used systemically to reduce the rate of in vivo aging of MSCs, including OP MSCs. Similarly, Sun et al. cultured MSCs from young and old mice on plastic, young extracellular matrix (ECM) and old ECM and have shown that the number and quality of MSCs from old mice could be improved when cultured on young ECM.88 In vivo ECM modulation could thus be another strategy to rescue or rejuvenate MSCs in OP and possibly, OA....
[...]
...This article addresses the comparison of in vitro MSC aging with in vivo MSC aging and discusses the concept of in vivo MSC “rejuvenation” and its future prospects for novel therapies for OP and OA....
[...]
...Increase in age is one of the risk factors for OA.(3) However, it is now...
[...]