Age-related changes in skeletal muscle: changes to life-style as a therapy.
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TLDR
The major proposed changes which occur in skeletal muscle during ageing are reviewed and evidence for changes in physical activity and nutrition as therapeutic approaches to combat age-related skeletal muscle wasting is highlighted.Citations
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Cancer cachexia and its pathophysiology: links with sarcopenia, anorexia and asthenia.
Sara Peixoto da Silva,Joana M.O. Santos,Maria Paula Costa e Silva,Rui Costa,Rui Costa,Rui Medeiros +5 more
TL;DR: Understanding the interplay and the differences between these conditions is critical to advance basic and translational research in this field, improving the accuracy of diagnosis and contributing to finally achieve effective therapies for affected patients.
Journal ArticleDOI
Use It or Lose It to Age: A Review of Bone and Muscle Communication
TL;DR: Until recently, it was assumed that the only interaction between muscle and bone is mechanical, that the muscle acts as a pulley and the bone as a lever to move the organism.
Journal ArticleDOI
Body composition and sarcopenia: The next-generation of personalized oncology and pharmacology?
Marc Hilmi,Anne Jouinot,Robert Burns,Frederic Pigneur,Rémi Mounier,Julien Gondin,Cindy Neuzillet,François Goldwasser +7 more
TL;DR: A comprehensive review providing a panoramic approach of the clinical, pharmacological and therapeutic implications of sarcopenia and body composition in oncology is proposed.
Journal ArticleDOI
Impact of Melatonin on Skeletal Muscle and Exercise.
TL;DR: In this review, the most recent evidence of dietary melatonin efficacy in age-related skeletal muscle disorders in cellular, preclinical, and clinical studies are discussed and the emerging impact of melatonin on physical activity is analyzed.
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Urolithin A augments angiogenic pathways in skeletal muscle by bolstering NAD+ and SIRT1.
Nandini Ghosh,Amitava Das,Nirupam Biswas,Surya Gnyawali,Kanhaiya Singh,Mahadeo Gorain,Carly Polcyn,Savita Khanna,Sashwati Roy,Chandan K. Sen +9 more
TL;DR: This work provides maiden evidence demonstrating that UA supplementation bolsters skeletal muscle ATP and NAD+ levels causing upregulated angiogenic pathways via a SIRT1-PGC-1α pathway.
References
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Journal Article
Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research.
TL;DR: These definitions are offered as an interpretational framework for comparing studies that relate physical activity, exercise, and physical fitness to health.
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Inflamm‐aging: An Evolutionary Perspective on Immunosenescence
Claudio Franceschi,Massimiliano Bonafè,Silvana Valensin,Fabiola Olivieri,Maria De Luca,Enzo Ottaviani,Giovanna De Benedictis +6 more
TL;DR: The beneficial effects of inflammation devoted to the neutralization of dangerous/harmful agents early in life and in adulthood become detrimental late in life in a period largely not foreseen by evolution, according to the antagonistic pleiotropy theory of aging.
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Identification of Ubiquitin Ligases Required for Skeletal Muscle Atrophy
Sue C. Bodine,Esther Latres,Susanne Baumhueter,Venus Lai,Lorna Nunez,Brian A. Clarke,William Poueymirou,Frank J. Panaro,Erqian Na,Kumar Dharmarajan,Zhen-Qiang Pan,David M. Valenzuela,Thomas M. DeChiara,Trevor Stitt,George D. Yancopoulos,David J. Glass +15 more
TL;DR: Two genes encode ubiquitin ligases that are potential drug targets for the treatment of muscle atrophy, and mice deficient in either MAFbx orMuRF1 were found to be resistant to atrophy.
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Reactive oxygen species in cell signaling
TL;DR: The evidence for ligand-induced generation of ROS, its cellular sources, and the signaling pathways that are activated is examined.
Journal ArticleDOI
Exercise training and nutritional supplementation for physical frailty in very elderly people
Maria A. Fiatarone,Evelyn F. O'Neill,Nancy D. Ryan,Karen M. Clements,Guido R. Solares,Miriam E. Nelson,Susan B. Roberts,Joseph J. Kehayias,Lewis A. Lipsitz,William J. Evans +9 more
TL;DR: High-intensity resistance exercise training is a feasible and effective means of counteracting muscle weakness and physical frailty in very elderly people, in contrast to multi-nutrient supplementation without concomitant exercise, which does not reduce muscle weakness orPhysical frailty.