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Journal ArticleDOI

Ageless: uma experiência emergente de (anti)envelhecimento

TL;DR: Baccarelli et al. as mentioned in this paper show that a média da expectativa de vida dos seres humanos já ultrapassava os 82 anos in Hong Kong, Japão, Itália, and Suíça (World Population Prospects, 2015).
Abstract: No último levantamento demográfico mundial, realizado United Nations [UN], publicado no ano de 2015, pudemos observar que a média da expectativa de vida dos seres humanos já ultrapassava os 82 anos em países como Hong Kong, Japão, Itália e Suíça (World Population Prospects, 2015). O mesmo levantamento ainda projeta que a expectativa de vida nos referidos países chegará a 87 anos nas próximas três décadas. Além de uma expectativa de vida alta, nota-se, na atualidade, o aumento significante do número de pessoas com idade acima de 100 anos espalhados por todo o mundo (Baccarelli et al., 2016). Crescem os estudos que buscam desvelar as caraterísticas do DNA e MRNA dos centenários e, quiçá, descobrirem o segredo da vida eterna (Baccarelli et al., 2016; He et al., 2016). Nesta conjuntura, as pessoas, o estado e o mercado se preparam, cada vez mais, para uma experiência de vida longa. Contudo, alguns indivíduos pretendem passar pelos anos sem necessariamente envelhecer. Ao contrário de abrir novas oportunidades para a velhice, a expectativa de vida cada vez maior tem revitalizado alguns anseios humanos muito antigos, como burlar, reverter, ocultar e transcender o envelhecimento. Por exemplo, os mitos e lendas do rejuvenescimento são bastante comuns na história de diversas culturas, já há muitos séculos, ou milênios. “O destino de Cartaphilus” na Islândia, a ‘fórmula da renovação da vida’ do deus hindu Indra, a ‘ambrosia’ dos deuses gregos, a ‘água da vida’ na Europa medieval e a ‘fonte da juventude’ presente em culturas do oriente e ocidente, são estórias que abordam um profundo desejo humano de buscar a juventude, tal como apontava Hopkins (1905). A pesquisadora e escritora francesa Simone de Beauvoir (1970-1990), em seu clássico ensaio A Velhice, lembra da importância assumida pelo mito da ‘fonte da juventude’ nas artes e na cultura no período do Renascimento. A imagem do corpo envelhecido deixou de ser apenas ‘desagradável’ e passou a ser considerada ‘repugnante’. Dos poemas de Erasmo de Roterdã, às pinturas de Quentin Matsys, o corpo envelhecido foi atacado, humilhado e desvalorizado, com especial ênfase ao corpo das mulheres, considerado pela cultura misógina daquele período como simples objeto de satisfação dos desejos dos homens. As imagens negativas do envelhecimento, construídas historicamente, foram revisadas somente a partir dos anos de 1970, com a invenção do que conhecemos, atualmente, por ‘terceira idade’. As políticas públicas, principalmente na Europa, passaram a focar os aposentados e pensionistas, a fim de inseri-los em atividades educacionais,
Citations
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DissertationDOI
21 Jun 2023
TL;DR: Melasma is uma hiperpigmentação na pele de cor acastanhada com ocorrência más comum em mulheres as discussed by the authors .
Abstract: Melasma é uma hiperpigmentação na pele de cor acastanhada com ocorrência mais comum em mulheres. Em geral as lesões são aparentes e de forma simétrica e podem vir a aparecer nas áreas fotoexpostas como a face e o pescoço. Atualmente a radiação ultravioleta, as alterações de hormônios durante a gravidez e os fatores genéticos acabam afetando a pele, gerando o melasma. Por ser uma doença crônica os pacientes podem ser afetados esteticamente e, em geral, o tratamento é desafiador, pois são lentos, inconsistentes e podem gerar efeitos colaterais como pigmentações imprevistas. Dessa forma é essencial o tratamento correto para cada tipo de melasma sendo que, a terapia a laser é eficaz em alguns casos, apresenta baixo custo e pode ser combinada a outros procedimentos apresentando bons resultados e poucos efeitos colaterais.
References
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Journal ArticleDOI
TL;DR: The caveats of the traditional mitochondrial free radical theory of aging are discussed and other possible mechanisms, including insulin/IGF-1 signaling and the target of rapamycin pathways, that underlie the central role of mitochondria in the aging process are highlighted.
Abstract: Over the last decade, accumulating evidence has suggested a causative link between mitochondrial dysfunction and major phenotypes associated with aging. Somatic mitochondrial DNA (mtDNA) mutations and respiratory chain dysfunction accompany normal aging, but the first direct experimental evidence that increased mtDNA mutation levels contribute to progeroid phenotypes came from the mtDNA mutator mouse. Recent evidence suggests that increases in aging-associated mtDNA mutations are not caused by damage accumulation, but rather are due to clonal expansion of mtDNA replication errors that occur during development. Here we discuss the caveats of the traditional mitochondrial free radical theory of aging and highlight other possible mechanisms, including insulin/IGF-1 signaling (IIS) and the target of rapamycin pathways, that underlie the central role of mitochondria in the aging process.

883 citations

Book
01 Jan 1986
TL;DR: Kaufman as discussed by the authors explored the effect of the aging process on the elderly and found that the elderly continue to participate in society, and more important continue to interpret their participation in the social world through themes constructed from these stories.
Abstract: Among the many studies of aging and the aged, there is comparatively little material in which the aged speak for themselves In this compelling study, Sharon Kaufman encourages just such expression, recording and presenting the voices of a number of old Americans Her informants tell their life stories and relate their most personal feelings about becoming old Each story is unique, and yet, presented together, they inevitable weave a clear pattern, one that clashes sharply with much current gerontological thought With this book, Sharon Kaufman allows us to understand the experience of the aging by listening to the aged themselves Kaufman, while maintaining objectivity, is able to draw an intimate portrait of her subjects We come to know these people as individuals and we become involved with their lives Through their words, we find that the aging process is not merely a period of sensory, functional, economic, and social decline Old people continue to participate in society, and more important continue to interpret their participation in the social world Through themes constructed from these stories, we can see how the old not only cope with losses, but how they create new meaning as they reformulate and build viable selves Creating identity, Kaufman stresses, is a lifelong process Sharon Kaufman's book will be of interest and value not only to students of gerontology and life span development, and to professionals in the field of aging, but to everyone who is concerned with the aging process itself As Sharon Kaufman says, "If we can find the sources of meaning held by the elderly and see how individuals put it all together, we will go a long way toward appreciating the complexity of human aging and the ultimate reality of coming to terms with one's whole life""

409 citations

Book ChapterDOI
01 Jan 1991

314 citations

Journal Article
TL;DR: A toast to biomedical science and biotechnology is offered, noting that the powers made possible by biomedical science can be used for non-therapeutic or ignoble purposes, serving ends that range from the frivolous and disquieting to the offensive and pernicious.
Abstract: Let me begin by offering a toast to biomedical science and biotechnology: May they live and be well. And may our children and grandchildren continue to reap their ever tastier fruit but without succumbing to their seductive promises of a perfect, better-than-human future, in which we shall all be as gods, ageless and blissful. As nearly everyone appreciates, we live near the beginning of the golden age of biotechnology. For the most part, we should be very glad that we do. We are many times over the beneficiaries of its cures for diseases, prolongation of life, and amelioration of suffering, psychic as well as somatic. We should be deeply grateful for the gifts of human ingenuity and cleverness, and for the devoted efforts of scientists, physicians, and entrepreneurs who have used these gifts to make those benefits possible. And, mindful that modern biology is just entering puberty, we suspect that the finest fruit is yet to come. Yet, notwithstanding these blessings, present and projected, we have also seen more than enough to make us anxious and concerned. For we recognize that the powers made possible by biomedical science can be used for non-therapeutic or ignoble purposes, serving ends that range from the frivolous and disquieting to the offensive and pernicious. These powers are available as instruments of bioterrorism (e.g., genetically engineered drug-resistant bacteria or drugs that obliterate memory); as agents of social control (e.g., drugs to tame rowdies or fertility-blockers for welfare recipients); and as means of trying to improve or perfect our bodies and minds and those of our children (e.g., genetically engineered super-muscles or drugs to improve memory). Anticipating possible threats to our security, freedom, and even our very humanity, many people are increasingly worried about where biotechnology may be taking us. We are concerned about what others might do to us, but also about what we might do to ourselves. We are concerned that our society might be harmed and that we ourselves might be diminished, indeed, in ways that could undermine the highest and richest possibilities of human life.

208 citations

Trending Questions (1)
What to do to not age?

The paper discusses the desire to defy aging but does not provide specific recommendations on how to prevent aging.