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Journal ArticleDOI

Airborne house dust mite antigen after vacuum cleaning

18 Aug 1990-The Lancet (Elsevier)-Vol. 336, Iss: 8712, pp 449-449
About: This article is published in The Lancet.The article was published on 1990-08-18. It has received 46 citations till now. The article focuses on the topics: House dust mite.
Citations
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Journal ArticleDOI
TL;DR: This systematic review and meta-analyses confirmed the findings of a previous study published in “Rhinitis and Asthma: Causes and Prevention, 2nd Ed.” (2015) as well as new findings of “Mechanisms of Respiratory Disease and Allergology,” which confirmed the role of EMTs in the development of these diseases.
Abstract: Authors Jan L. Brozek, MD, PhD – Department of Clinical Epidemiology & Biostatistics and Medicine, McMaster University, Hamilton, Canada Jean Bousquet, MD, PhD – Service des Maladies Respiratoires, Hopital Arnaud de Villeneuve, Montpellier, France, INSERM, CESP U1018, Respiratory and Environmental Epidemiology Team, France, and WHO Collaborating Center for Rhinitis and Asthma Carlos E. Baena-Cagnani, MD – Faculty of Medicine, Catholic University of Cordoba, Cordoba, Argentina Sergio Bonini, MD – Institute of Neurobiology and Molecular Medicine – CNR, Rome, Italy and Department of Medicine, Second University of Naples, Naples, Italy G. Walter Canonica, MD – Allergy & Respiratory Diseases, DIMI, Department of Internal Medicine, University of Genoa, Genoa, Italy Thomas B. Casale, MD – Division of Allergy and Immunology, Department of Medicine, Creighton University, Omaha, Nebraska, USA Roy Gerth van Wijk, MD, PhD – Section of Allergology, Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, the Netherlands Ken Ohta, MD, PhD – Division of Respiratory Medicine and Allergology, Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan Torsten Zuberbier, MD – Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, Berlin, Germany Holger J. Schunemann, MD, PhD, MSc – Department of Clinical Epidemiology & Biostatistics and Medicine, McMaster University, Hamilton, Canada

3,368 citations

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TL;DR: In this article, the relationship between indoor air pollution and health has been investigated, and the effects of exposure to combustion products from heating, cooking, and smoking of tobacco have been examined.

1,225 citations

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TL;DR: The activity of atopic dermatitis can be greatly reduced by effective HDM avoidance and methods to identify individuals who will benefit most from such measures are needed.

398 citations

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TL;DR: *Department of Zoology, University of Glasgow, Glasgow G12 8QQ, U.K; **The Blackrock Clinic, Blackrock, Co.
Abstract: *Department of Zoology, University of Glasgow, Glasgow G12 8QQ, U.K.; ^Regional Department of Respiratory Medicine, East Birmingham Hospital, Bordesley Green East, Birmingham B9 5ST, U.K.; % Respiratory Research Group, Department of Child Health, Royal Hospital for Sick Children, Bristol BS2 8BJ, U.K.; ^Medicine I, Level D, Centre Block, Southampton General Hospital, Southampton SO9 4XY, U.K.; '^Allergy Analysis Centre, 31 Station Lane, Witney, Oxfordshire OX8 6AN, U.K.; **The Blackrock Clinic, Blackrock, Co. Dublin, Republic of Ireland. ^•\Cardiothoracic Centre, Broadgreen Hospital, Liverpool L14 3LB, U.K.; ^Department of Child Health, Southampton General Hospital, Southampton S09 4XY, U.K.; ^Regional Department of Respiratory Physiology, Wythenshawe Hospital, Manchester M23 9LT, U.K.

330 citations

Journal ArticleDOI
TL;DR: The infonnation from diverse studies which when combined strongly suggests that exposure to allergens is an important cause of asthma are reviewed, focusing on house dust mite allergens because it is the most complete.
Abstract: It is well known that inhalation of an allergen is capable of inducing wheeze in a sensitized individual. But the idea that allergen exposure is a primary cause of asthma has encountered opposition. Recent advances have made it possible to study the relationship between house dust mite allergen exposure and asthma [reviewed in i]. These include the purification of the major allergens [2], the development of ELISA techniques which have facilitated allergen measurement [3] and a series of epidemiological studies from many parts of the world. In this article, we review the infonnation from diverse studies which when combined strongly suggests that exposure to allergens is an important cause of asthma. We focus on the evidence related to house dust mite allergens because it is the most complete. However there are a number of other inhaled allergens which are of importance in individual cases, in certain geographic areas or at specific times of the year. The implication from these studies is that the primary cause of asthma, especially the asthma occurring in children and young adults, is inhalation of allergens. For an allergen to have a clinical effect, prior sensitization must have occurred. Sensitization requires the combination of an innate ability to respond and exposure. Immediate sensitivity, characterized by IgE antibody production, is part of the immune response to these proteins, which also involves antigen presenting cells, T cells, B cells and other effector ceils. Exposure of a nonsensitized individual to even large quantities of an allergen will not provoke symptoms, whereas a sensitized individual is capable of reacting to extraordinarily small concentrations of allergens, i.e. in the picogram range. Immediate sensitivity can be measured by either the level of allergen specific IgE antibody or by skin testing [4,5,6]. The development of asthma can be considered to consist of two distinct processes: (i) a period resulting in sensitization followed by (ii) exposure of the sensitized person resulting in inflammation and ciinical wheeze. This latter process was elegantly referred to as 'excitement' in the early literature. The presence of inflammation may make the lung more sensitive not only to the specific allergen

298 citations

References
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Journal ArticleDOI
TL;DR: The finding of the house-dust mite seems to supply an answer to all factors, and the keystone of the theory is formed by the fact that after being made equivalent, extracts of house dust and mite cultures gave skin reactions which were both qualitatively and quantitatively indistinguishable.

417 citations

Journal ArticleDOI
TL;DR: Two types of nozzles were compared for efficiency in extracting dust and house-dust mites from textile floor-coverings and the motorized nozzle appeared to be significantly more effective in extracts dust; however, for the mites no such difference could be noted.
Abstract: Two types of nozzles were compared for efficiency in extracting dust and house-dust mites from textile floor-coverings. From 21 homes, 2 m2 from the wall-to-wall floor-covering in the bedrooms were vacuumed. On 1-m2 the non-motorized nozzle was used, on the other 1-m2 a motorized nozzle was used. Before this sampling both test surfaces were vacuumed using the non-motorized nozzle in order to assess the mite numbers at the beginning of the experiment. The motorized nozzle appeared to be significantly more effective in extracting dust; however, for the mites no such difference could be noted.

7 citations