Aldol Reaction of Iododifluoroacetate-Zn and 2,2-Difluoroketene Silyl Acetal.

TL;DR: Generation of the reformatsky reagent of difluoracetate from the iodide and the diffluoroketene silyl acetal and their aldol reaction are described in this article.

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About: This article is published in Tetrahedron Letters.The article was published on 1988-01-01. It has received 106 citations till now. The article focuses on the topics: Acetal & Aldol reaction.

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University of Rouen¹

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Update 1 of: Asymmetric Fluorination, Trifluoromethylation, and Perfluoroalkylation Reactions

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Tianjin University¹, Institut national des sciences appliquées de Rouen²

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Methods for the synthesis of gem-difluoromethylene compounds

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Matthew J. Tozer, Timothée F. Herpin

24 Jun 1996-Tetrahedron

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Fluorinated organometallics: Perfluoroalkyl and functionalized perfluoroalkyl organometallic reagents in organic synthesis

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Donald J. Burton¹, Zhen-Yu Yang¹•Institutions (1)

University of Iowa¹

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Synthesis of chiral and bioactive fluoroorganic compounds

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Giuseppe Resnati¹•Institutions (1)

Instituto Politécnico Nacional¹

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A remarkably simple preparation of (trifluoromethyl)cadmium and -zinc reagents directly from difluorodihalomethanes

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Donald J. Burton, Denise M. Wiemers

01 Aug 1985-Journal of the American Chemical Society

153 citations

Journal Article•DOI•

2,2-Difluoro-3-hydroxyesters by reformatskii reaction

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E. Ann Hallinan¹, Josef Fried¹•Institutions (1)

University of Chicago¹

01 Jan 1984-Tetrahedron Letters

TL;DR: In this article, the reformatskii addition to aldehydes and ketones to form 2,2-difluoro-3-hydroxyesters is described.

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135 citations

Journal Article•DOI•

Synthesis of 2,2-difluoroesters by iododifluoroacetate-copper with organic halides

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Takeo Taguchi, Osamu Kitagawa, Tsutomu Morikawa, Tohru Nishiwaki, Hideya Uehara, Hatsumi Endo, Yoshiro Kobayashi - Show less +3 more

01 Jan 1986-Tetrahedron Letters

TL;DR: In this article, the formation of CC bond through reactions of iododifluoroacetate-copper with various organic halides in aprotic solvent proceeds effectively to give 2,2-difluoroesters in good yield.

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104 citations

Journal Article•DOI•

Difluorostatine- and difluorostatone-containing peptides as potent and specific renin inhibitors.

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Suvit Thaisrivongs, Donald T. Pals, Warren M. Kati, Steve R. Turner, Lisa M. Thomasco - Show less +1 more

01 Nov 1985-Journal of Medicinal Chemistry

61 citations

Journal Article•DOI•

Synthesis and properties of 7,7-difluoro derivatives of the 2,6-dioxa[3.1.1]bicycloheptane ring system present in thromboxane A2

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Josef Fried, E. Ann Hallinan, Mitchell J. Szwedo