Alginate: properties and biomedical applications
TL;DR: This review will provide a comprehensive overview of general properties of alginate and its hydrogels, their biomedical applications, and suggest new perspectives for future studies with these polymers.
About: This article is published in Progress in Polymer Science.The article was published on 2012-01-01 and is currently open access. It has received 5372 citations till now. The article focuses on the topics: Self-healing hydrogels.
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TL;DR: An updated summary of recent advances in the field of nanomedicines and nano based drug delivery systems through comprehensive scrutiny of the discovery and application of nanomaterials in improving both the efficacy of novel and old drugs and selective diagnosis through disease marker molecules is presented.
Abstract: Nanomedicine and nano delivery systems are a relatively new but rapidly developing science where materials in the nanoscale range are employed to serve as means of diagnostic tools or to deliver therapeutic agents to specific targeted sites in a controlled manner Nanotechnology offers multiple benefits in treating chronic human diseases by site-specific, and target-oriented delivery of precise medicines Recently, there are a number of outstanding applications of the nanomedicine (chemotherapeutic agents, biological agents, immunotherapeutic agents etc) in the treatment of various diseases The current review, presents an updated summary of recent advances in the field of nanomedicines and nano based drug delivery systems through comprehensive scrutiny of the discovery and application of nanomaterials in improving both the efficacy of novel and old drugs (eg, natural products) and selective diagnosis through disease marker molecules The opportunities and challenges of nanomedicines in drug delivery from synthetic/natural sources to their clinical applications are also discussed In addition, we have included information regarding the trends and perspectives in nanomedicine area
3,112 citations
TL;DR: This Review discusses how different mechanisms interact and can be integrated to exert fine control in time and space over the drug presentation, and collects experimental release data from the literature and presents quantitative comparisons between different systems to provide guidelines for the rational design of hydrogel delivery systems.
Abstract: Hydrogel delivery systems can leverage therapeutically beneficial outcomes of drug delivery and have found clinical use. Hydrogels can provide spatial and temporal control over the release of various therapeutic agents, including small-molecule drugs, macromolecular drugs and cells. Owing to their tunable physical properties, controllable degradability and capability to protect labile drugs from degradation, hydrogels serve as a platform in which various physiochemical interactions with the encapsulated drugs control their release. In this Review, we cover multiscale mechanisms underlying the design of hydrogel drug delivery systems, focusing on physical and chemical properties of the hydrogel network and the hydrogel-drug interactions across the network, mesh, and molecular (or atomistic) scales. We discuss how different mechanisms interact and can be integrated to exert fine control in time and space over the drug presentation. We also collect experimental release data from the literature, review clinical translation to date of these systems, and present quantitative comparisons between different systems to provide guidelines for the rational design of hydrogel delivery systems.
2,457 citations
TL;DR: Progress towards controlled synthesis of alginate derivatives, and the properties and applications of these derivatives are reviewed.
1,182 citations
Cites background from "Alginate: properties and biomedical..."
...have recently described alginates as “blank slates” [6]....
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TL;DR: A bioink that combines the outstanding shear thinning properties of nanofibrillated cellulose (NFC) with the fast cross-linking ability of alginate with the potential use of nanocellulose for 3D bioprinting of living tissues and organs is formulated.
1,169 citations
TL;DR: In this article, the authors present the past and current efforts with a brief description on the featured properties of hydrogel membranes fabricated from biopolymers and synthetic ones for wound dressing applications.
1,059 citations
Cites background from "Alginate: properties and biomedical..."
...4), where the ratio between them adjusts the elasticity of obtained crosslinked alginic gels [52]....
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References
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TL;DR: Chitin is the second most important natural polymer in the world as mentioned in this paper, and the main sources of chitin are two marine crustaceans, shrimp and crabs, which are used for food, cosmetics, biomedical and pharmaceutical applications.
6,365 citations
"Alginate: properties and biomedical..." refers background in this paper
...Chitosan is a cationic polymer and has been widely used in the areas of food, cosmetics, biomedical and pharmaceutical applications, [68], due to its biocompatibility and other favorable properties....
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Journal Article•
5,981 citations
4,511 citations
"Alginate: properties and biomedical..." refers methods in this paper
...In this approach, hydrogels are used to deliver cells to the desired site, provide a space for new tissue formation, and control the structure and function of the engineered tissue [6]....
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TL;DR: Angiogenesis research will probably change the face of medicine in the next decades, with more than 500 million people worldwide predicted to benefit from pro- or anti-angiogenesis treatments.
Abstract: The growth of blood vessels (a process known as angiogenesis) is essential for organ growth and repair. An imbalance in this process contributes to numerous malignant, inflammatory, ischaemic, infectious and immune disorders. Recently, the first anti-angiogenic agents have been approved for the treatment of cancer and blindness. Angiogenesis research will probably change the face of medicine in the next decades, with more than 500 million people worldwide predicted to benefit from pro- or anti-angiogenesis treatments.
3,300 citations
"Alginate: properties and biomedical..." refers background in this paper
...Blood vessels—Networks of blood vessels are critical for transport of oxygen and nutrients to all tissues, removal of metabolic waste products, and trafficking of stem and progenitor cells, which are critical for organ growth in the embryo and wound repair in the adult [114]....
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TL;DR: It is shown that spedfic binding of divalent cations to a polysaechafide polyelectro]ym, leading firm cohesion between the chains, can cause characteristic effects in the c~rcutar diehroism spectrum which are understandabb in terms of modem theo~, [ l ].
2,505 citations