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Proceedings ArticleDOI

Alignment by maximization of mutual information

20 Jun 1995-Vol. 24, Iss: 2, pp 16-23
TL;DR: A new information-theoretic approach is presented for finding the pose of an object in an image that works well in domains where edge or gradient-magnitude based methods have difficulty, yet it is more robust then traditional correlation.
Abstract: A new information-theoretic approach is presented for finding the pose of an object in an image. The technique does not require information about the surface properties of the object, besides its shape, and is robust with respect to variations of illumination. In our derivation, few assumptions are made about the nature of the imaging process. As a result, the algorithms are quite general and can foreseeably be used in a wide variety of imaging situations. Experiments are presented that demonstrate the approach in registering magnetic resonance images, aligning a complex 3D object model to real scenes including clutter and occlusion, tracking a human head in a video sequence and aligning a view-based 2D object model to real images. The method is based on a formulation of the mutual information between the model and the image. As applied in this paper, the technique is intensity-based, rather than feature-based. It works well in domains where edge or gradient-magnitude based methods have difficulty, yet it is more robust then traditional correlation. Additionally, it has an efficient implementation that is based on stochastic approximation. >

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Citations
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Journal ArticleDOI
TL;DR: The results clearly indicate that the proposed nonrigid registration algorithm is much better able to recover the motion and deformation of the breast than rigid or affine registration algorithms.
Abstract: In this paper the authors present a new approach for the nonrigid registration of contrast-enhanced breast MRI. A hierarchical transformation model of the motion of the breast has been developed. The global motion of the breast is modeled by an affine transformation while the local breast motion is described by a free-form deformation (FFD) based on B-splines. Normalized mutual information is used as a voxel-based similarity measure which is insensitive to intensity changes as a result of the contrast enhancement. Registration is achieved by minimizing a cost function, which represents a combination of the cost associated with the smoothness of the transformation and the cost associated with the image similarity. The algorithm has been applied to the fully automated registration of three-dimensional (3-D) breast MRI in volunteers and patients. In particular, the authors have compared the results of the proposed nonrigid registration algorithm to those obtained using rigid and affine registration techniques. The results clearly indicate that the nonrigid registration algorithm is much better able to recover the motion and deformation of the breast than rigid or affine registration algorithms.

5,490 citations

Journal ArticleDOI
TL;DR: The results demonstrate that subvoxel accuracy with respect to the stereotactic reference solution can be achieved completely automatically and without any prior segmentation, feature extraction, or other preprocessing steps which makes this method very well suited for clinical applications.
Abstract: A new approach to the problem of multimodality medical image registration is proposed, using a basic concept from information theory, mutual information (MI), or relative entropy, as a new matching criterion. The method presented in this paper applies MI to measure the statistical dependence or information redundancy between the image intensities of corresponding voxels in both images, which is assumed to be maximal if the images are geometrically aligned. Maximization of MI is a very general and powerful criterion, because no assumptions are made regarding the nature of this dependence and no limiting constraints are imposed on the image content of the modalities involved. The accuracy of the MI criterion is validated for rigid body registration of computed tomography (CT), magnetic resonance (MR), and photon emission tomography (PET) images by comparison with the stereotactic registration solution, while robustness is evaluated with respect to implementation issues, such as interpolation and optimization, and image content, including partial overlap and image degradation. Our results demonstrate that subvoxel accuracy with respect to the stereotactic reference solution can be achieved completely automatically and without any prior segmentation, feature extraction, or other preprocessing steps which makes this method very well suited for clinical applications.

4,773 citations

Journal ArticleDOI
TL;DR: A new information-theoretic approach is presented for finding the pose of an object in an image that works well in domains where edge or gradient-magnitude based methods have difficulty, yet it is more robust than traditional correlation.
Abstract: A new information-theoretic approach is presented for finding the pose of an object in an image. The technique does not require information about the surface properties of the object, besides its shape, and is robust with respect to variations of illumination. In our derivation few assumptions are made about the nature of the imaging process. As a result the algorithms are quite general and may foreseeably be used in a wide variety of imaging situations. Experiments are presented that demonstrate the approach registering magnetic resonance (MR) images, aligning a complex 3D object model to real scenes including clutter and occlusion, tracking a human head in a video sequence and aligning a view-based 2D object model to real images. The method is based on a formulation of the mutual information between the model and the image. As applied here the technique is intensity-based, rather than feature-based. It works well in domains where edge or gradient-magnitude based methods have difficulty, yet it is more robust than traditional correlation. Additionally, it has an efficient implementation that is based on stochastic approximation.

3,584 citations


Cites background from "Alignment by maximization of mutual..."

  • ...We have proven that the technique will always converge to a pose estimate that is close to locally optimal (Viola, 1995)....

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  • ...Additional technical details on the relationship between mutual information and other measures of alignment may be found in (Viola, 1995)....

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  • ...Though weighted neighbor likelihood is a powerful technique, it has three significant drawbacks (see (Viola, 1995) for a more detailed discussion)....

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  • ...Our system works in the presence of occlusion because the measure of mutual information used is “robust” to outliers and noise (see (Viola, 1995) for further discussion)....

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  • ...Our system works in the presence of occlusion because the measure of mutual information used is \robust" to outliers and noise (see (Viola, 1995) for further discussion)....

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Journal ArticleDOI
TL;DR: The software consists of a collection of algorithms that are commonly used to solve medical image registration problems, and allows the user to quickly configure, test, and compare different registration methods for a specific application.
Abstract: Medical image registration is an important task in medical image processing. It refers to the process of aligning data sets, possibly from different modalities (e.g., magnetic resonance and computed tomography), different time points (e.g., follow-up scans), and/or different subjects (in case of population studies). A large number of methods for image registration are described in the literature. Unfortunately, there is not one method that works for all applications. We have therefore developed elastix, a publicly available computer program for intensity-based medical image registration. The software consists of a collection of algorithms that are commonly used to solve medical image registration problems. The modular design of elastix allows the user to quickly configure, test, and compare different registration methods for a specific application. The command-line interface enables automated processing of large numbers of data sets, by means of scripting. The usage of elastix for comparing different registration methods is illustrated with three example experiments, in which individual components of the registration method are varied.

3,444 citations

Journal ArticleDOI
TL;DR: A survey of recent publications concerning medical image registration techniques is presented, according to a model based on nine salient criteria, the main dichotomy of which is extrinsic versus intrinsic methods.

3,426 citations

References
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Journal ArticleDOI
TL;DR: This final installment of the paper considers the case where the signals or the messages or both are continuously variable, in contrast with the discrete nature assumed until now.
Abstract: In this final installment of the paper we consider the case where the signals or the messages or both are continuously variable, in contrast with the discrete nature assumed until now. To a considerable extent the continuous case can be obtained through a limiting process from the discrete case by dividing the continuum of messages and signals into a large but finite number of small regions and calculating the various parameters involved on a discrete basis. As the size of the regions is decreased these parameters in general approach as limits the proper values for the continuous case. There are, however, a few new effects that appear and also a general change of emphasis in the direction of specialization of the general results to particular cases.

65,425 citations


"Alignment by maximization of mutual..." refers background in this paper

  • ...Nonetheless, most of the credit for de ning entropy and promoting its use in data analysis and engineering falls to Shannon (Shannon, 1948)....

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Book
01 Jan 1991
TL;DR: The author examines the role of entropy, inequality, and randomness in the design of codes and the construction of codes in the rapidly changing environment.
Abstract: Preface to the Second Edition. Preface to the First Edition. Acknowledgments for the Second Edition. Acknowledgments for the First Edition. 1. Introduction and Preview. 1.1 Preview of the Book. 2. Entropy, Relative Entropy, and Mutual Information. 2.1 Entropy. 2.2 Joint Entropy and Conditional Entropy. 2.3 Relative Entropy and Mutual Information. 2.4 Relationship Between Entropy and Mutual Information. 2.5 Chain Rules for Entropy, Relative Entropy, and Mutual Information. 2.6 Jensen's Inequality and Its Consequences. 2.7 Log Sum Inequality and Its Applications. 2.8 Data-Processing Inequality. 2.9 Sufficient Statistics. 2.10 Fano's Inequality. Summary. Problems. Historical Notes. 3. Asymptotic Equipartition Property. 3.1 Asymptotic Equipartition Property Theorem. 3.2 Consequences of the AEP: Data Compression. 3.3 High-Probability Sets and the Typical Set. Summary. Problems. Historical Notes. 4. Entropy Rates of a Stochastic Process. 4.1 Markov Chains. 4.2 Entropy Rate. 4.3 Example: Entropy Rate of a Random Walk on a Weighted Graph. 4.4 Second Law of Thermodynamics. 4.5 Functions of Markov Chains. Summary. Problems. Historical Notes. 5. Data Compression. 5.1 Examples of Codes. 5.2 Kraft Inequality. 5.3 Optimal Codes. 5.4 Bounds on the Optimal Code Length. 5.5 Kraft Inequality for Uniquely Decodable Codes. 5.6 Huffman Codes. 5.7 Some Comments on Huffman Codes. 5.8 Optimality of Huffman Codes. 5.9 Shannon-Fano-Elias Coding. 5.10 Competitive Optimality of the Shannon Code. 5.11 Generation of Discrete Distributions from Fair Coins. Summary. Problems. Historical Notes. 6. Gambling and Data Compression. 6.1 The Horse Race. 6.2 Gambling and Side Information. 6.3 Dependent Horse Races and Entropy Rate. 6.4 The Entropy of English. 6.5 Data Compression and Gambling. 6.6 Gambling Estimate of the Entropy of English. Summary. Problems. Historical Notes. 7. Channel Capacity. 7.1 Examples of Channel Capacity. 7.2 Symmetric Channels. 7.3 Properties of Channel Capacity. 7.4 Preview of the Channel Coding Theorem. 7.5 Definitions. 7.6 Jointly Typical Sequences. 7.7 Channel Coding Theorem. 7.8 Zero-Error Codes. 7.9 Fano's Inequality and the Converse to the Coding Theorem. 7.10 Equality in the Converse to the Channel Coding Theorem. 7.11 Hamming Codes. 7.12 Feedback Capacity. 7.13 Source-Channel Separation Theorem. Summary. Problems. Historical Notes. 8. Differential Entropy. 8.1 Definitions. 8.2 AEP for Continuous Random Variables. 8.3 Relation of Differential Entropy to Discrete Entropy. 8.4 Joint and Conditional Differential Entropy. 8.5 Relative Entropy and Mutual Information. 8.6 Properties of Differential Entropy, Relative Entropy, and Mutual Information. Summary. Problems. Historical Notes. 9. Gaussian Channel. 9.1 Gaussian Channel: Definitions. 9.2 Converse to the Coding Theorem for Gaussian Channels. 9.3 Bandlimited Channels. 9.4 Parallel Gaussian Channels. 9.5 Channels with Colored Gaussian Noise. 9.6 Gaussian Channels with Feedback. Summary. Problems. Historical Notes. 10. Rate Distortion Theory. 10.1 Quantization. 10.2 Definitions. 10.3 Calculation of the Rate Distortion Function. 10.4 Converse to the Rate Distortion Theorem. 10.5 Achievability of the Rate Distortion Function. 10.6 Strongly Typical Sequences and Rate Distortion. 10.7 Characterization of the Rate Distortion Function. 10.8 Computation of Channel Capacity and the Rate Distortion Function. Summary. Problems. Historical Notes. 11. Information Theory and Statistics. 11.1 Method of Types. 11.2 Law of Large Numbers. 11.3 Universal Source Coding. 11.4 Large Deviation Theory. 11.5 Examples of Sanov's Theorem. 11.6 Conditional Limit Theorem. 11.7 Hypothesis Testing. 11.8 Chernoff-Stein Lemma. 11.9 Chernoff Information. 11.10 Fisher Information and the Cram-er-Rao Inequality. Summary. Problems. Historical Notes. 12. Maximum Entropy. 12.1 Maximum Entropy Distributions. 12.2 Examples. 12.3 Anomalous Maximum Entropy Problem. 12.4 Spectrum Estimation. 12.5 Entropy Rates of a Gaussian Process. 12.6 Burg's Maximum Entropy Theorem. Summary. Problems. Historical Notes. 13. Universal Source Coding. 13.1 Universal Codes and Channel Capacity. 13.2 Universal Coding for Binary Sequences. 13.3 Arithmetic Coding. 13.4 Lempel-Ziv Coding. 13.5 Optimality of Lempel-Ziv Algorithms. Compression. Summary. Problems. Historical Notes. 14. Kolmogorov Complexity. 14.1 Models of Computation. 14.2 Kolmogorov Complexity: Definitions and Examples. 14.3 Kolmogorov Complexity and Entropy. 14.4 Kolmogorov Complexity of Integers. 14.5 Algorithmically Random and Incompressible Sequences. 14.6 Universal Probability. 14.7 Kolmogorov complexity. 14.9 Universal Gambling. 14.10 Occam's Razor. 14.11 Kolmogorov Complexity and Universal Probability. 14.12 Kolmogorov Sufficient Statistic. 14.13 Minimum Description Length Principle. Summary. Problems. Historical Notes. 15. Network Information Theory. 15.1 Gaussian Multiple-User Channels. 15.2 Jointly Typical Sequences. 15.3 Multiple-Access Channel. 15.4 Encoding of Correlated Sources. 15.5 Duality Between Slepian-Wolf Encoding and Multiple-Access Channels. 15.6 Broadcast Channel. 15.7 Relay Channel. 15.8 Source Coding with Side Information. 15.9 Rate Distortion with Side Information. 15.10 General Multiterminal Networks. Summary. Problems. Historical Notes. 16. Information Theory and Portfolio Theory. 16.1 The Stock Market: Some Definitions. 16.2 Kuhn-Tucker Characterization of the Log-Optimal Portfolio. 16.3 Asymptotic Optimality of the Log-Optimal Portfolio. 16.4 Side Information and the Growth Rate. 16.5 Investment in Stationary Markets. 16.6 Competitive Optimality of the Log-Optimal Portfolio. 16.7 Universal Portfolios. 16.8 Shannon-McMillan-Breiman Theorem (General AEP). Summary. Problems. Historical Notes. 17. Inequalities in Information Theory. 17.1 Basic Inequalities of Information Theory. 17.2 Differential Entropy. 17.3 Bounds on Entropy and Relative Entropy. 17.4 Inequalities for Types. 17.5 Combinatorial Bounds on Entropy. 17.6 Entropy Rates of Subsets. 17.7 Entropy and Fisher Information. 17.8 Entropy Power Inequality and Brunn-Minkowski Inequality. 17.9 Inequalities for Determinants. 17.10 Inequalities for Ratios of Determinants. Summary. Problems. Historical Notes. Bibliography. List of Symbols. Index.

45,034 citations


"Alignment by maximization of mutual..." refers background in this paper

  • ...This approach is equivalent to minimizing the cross entropy of the estimated distribution with the true distribution (Cover and Thomas, 1991)....

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  • ...Log likelihood and entropy are closely related (see (Cover and Thomas, 1991) for an excellent review of entropy and its relation to statistics)....

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Book
16 Jul 1998
TL;DR: Thorough, well-organized, and completely up to date, this book examines all the important aspects of this emerging technology, including the learning process, back-propagation learning, radial-basis function networks, self-organizing systems, modular networks, temporal processing and neurodynamics, and VLSI implementation of neural networks.
Abstract: From the Publisher: This book represents the most comprehensive treatment available of neural networks from an engineering perspective. Thorough, well-organized, and completely up to date, it examines all the important aspects of this emerging technology, including the learning process, back-propagation learning, radial-basis function networks, self-organizing systems, modular networks, temporal processing and neurodynamics, and VLSI implementation of neural networks. Written in a concise and fluid manner, by a foremost engineering textbook author, to make the material more accessible, this book is ideal for professional engineers and graduate students entering this exciting field. Computer experiments, problems, worked examples, a bibliography, photographs, and illustrations reinforce key concepts.

29,130 citations

Book
01 Jan 1965
TL;DR: This chapter discusses the concept of a Random Variable, the meaning of Probability, and the axioms of probability in terms of Markov Chains and Queueing Theory.
Abstract: Part 1 Probability and Random Variables 1 The Meaning of Probability 2 The Axioms of Probability 3 Repeated Trials 4 The Concept of a Random Variable 5 Functions of One Random Variable 6 Two Random Variables 7 Sequences of Random Variables 8 Statistics Part 2 Stochastic Processes 9 General Concepts 10 Random Walk and Other Applications 11 Spectral Representation 12 Spectral Estimation 13 Mean Square Estimation 14 Entropy 15 Markov Chains 16 Markov Processes and Queueing Theory

13,886 citations