Open AccessJournal Article
Alkaloids from Piper nigrum and Piper betle.
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In this article, the roots of Piper nigrum and the aerial parts of Piper betle have yielded several alkaloids, including pellitorine, piperidine and piperine.Abstract:
An investigation, on the roots of Piper nigrum and the aerial parts of Piper betle, has yielded several alkaloids. The dried root sample of Piper nigrum was extracted using various solvents in increasing polarity. The dried aerial part of Piper betle was extracted using the Soxhlet extraction method. The alkaloids isolated were pellitorine(1), (E)-1-[3',4'- (Methylenedioxy)cinnamoyl]piperidine(2), piperine(3), piperolactam D(4), cepharadione A(5), and 2,4-tetradecadienoic acid isobutyl amide(6). These compounds were isolated using chromatographic methods, while the elucidation of the structures was carried out using MS, IR and NMR techniques. The extracts of Piper nigrum and Piper betle were also tested for cytotoxicity activities. This is the first report on (E)-1-[3',4'-(Methylenedioxy)cinnamoyl] piperidine(2) from Piper nigrum as a natural product.read more
Citations
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Biological role of Piper nigrum L. (Black pepper): A review
TL;DR: A review based on the biological role of Piper nigrum can provide that the peppercorn or other parts can be use as crude drug for various diseases while the secondary metabolites such as piperine can be used for specific diseases.
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A systematic review on black pepper (Piper nigrum L.): from folk uses to pharmacological applications.
Heerasing Takooree,Muhammad Zakariyyah Aumeeruddy,Kannan R.R. Rengasamy,Katharigatta N. Venugopala,Rajesh Jeewon,Gokhan Zengin,Mohamad Fawzi Mahomoodally +6 more
TL;DR: P. nigrum should not only be regarded as “King of spices” but can also be considered as part of the kingdom of medicinal agents, comprising a panoply of bioactive compounds with potential nutraceutical and pharmaceutical applications.
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Isolation of piperdine from Piper nigrum and its antiproliferative activity.
TL;DR: In this article, the authors extracted phytochemical compounds in different solvent system in plants belonging to the pyridine group of Piperaceae family, such as P. nigrum, P. longum and P. cubeba.
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Piper betle L. leaf extracts inhibit quorum sensing of shrimp pathogen Vibrio harveyi and protect Penaeus vannamei postlarvae against bacterial infection
John Paul Matthew D. Guzman,Pattanan Yatip,Pattanan Yatip,Chumporn Soowannayan,Chumporn Soowannayan,Mary Beth B. Maningas +5 more
TL;DR: This mechanism may be used as a target for bioactive compounds in controlling V. harveyi infections in shrimp through the formation of biofilm as a result of bacterial cell-to-cell communication or quorum sensing (QS).
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Acute Toxicity Study and In-vivo Anti-inflammatory Activity of Different Fractions of Curculigo orchioides Gaertn. Rhizome in Albino Wistar Rats
Mohammad Asif,Ankush Kumar +1 more
TL;DR: The results suggest that the anti-inflammatory effects of the extracts as claimed in folk Indian medicine, as well as the acute toxicity evaluation, were not toxic up to 2000 mg/kg (p.o).
References
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Journal ArticleDOI
Larvicidal activity of isobutylamides identified in Piper nigrum fruits against three mosquito species
TL;DR: Structural-activity relationships indicate that the N-isobutylamine moiety might play a crucial role in the larvicidal activity, but the methylenedioxyphenyl moiety does not appear essential for toxicity.
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The Piperaceae Amides I: Structure of Pipercide, A New Insecticidal Amide from Piper nigrum L.
TL;DR: The Piperaceae Amides I: Structure of Pipercide, A New Insecticidal Amide from Piper nigrum L. as discussed by the authors, Vol. 43, No. 7, pp. 1609-1611
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Analysis of Piperaceae germplasm by HPLC and LCMS: a method for isolating and identifying unsaturated amides from Piper spp extracts.
Ian M. Scott,Evaloni Puniani,Helen R. Jensen,John Livesey,Luis Poveda,Pablo Sanchez-Vindas,Tony Durst,John T. Arnason +7 more
TL;DR: A method for extraction and high performance liquid chromatography-mass spectrometer (HPLC-MS) analysis of the medicinally important genus Piper (Piperaceae) was developed, and the biological activity of six Costa Rican Piper species assessed by mosquito larval bioassays correlated well with piperamide content.
Journal ArticleDOI
Aristolactams and 4,5-dioxoaporphines from Piper longum
TL;DR: In this article, nine alkaloids were isolated from the cold ethanol extract of Piper longum roots, of which six known compounds were identified as cepharadione B, cep-caradione A, piperanone B, aristolactam AII, norcepharadione C, and 2-hydroxy-1-methoxy-6-methyl-4H-dibenzo[de, g]quinoline-4,5(6H)-dione.