scispace - formally typeset
Search or ask a question
Journal ArticleDOI

Alkyl nitrite-metal halide deamination reactions. 6. Direct synthesis of arenediazonium tetrafluoroborate salts from aromatic amines, tert-butyl nitrite, and boron trifluoride etherate in anhydrous media

01 Apr 1979-Journal of Organic Chemistry (American Chemical Society)-Vol. 44, Iss: 9, pp 1572-1574
About: This article is published in Journal of Organic Chemistry.The article was published on 1979-04-01. It has received 197 citations till now. The article focuses on the topics: Boron trifluoride & Nitrite.
Citations
More filters
Journal ArticleDOI
TL;DR: 1. Advantages and disadvantages of Chemical Redox Agents, 2. Reversible vs Irreversible ET Reagents, 3. Categorization of Reagent Strength.
Abstract: 1. Advantages of Chemical Redox Agents 878 2. Disadvantages of Chemical Redox Agents 879 C. Potentials in Nonaqueous Solvents 879 D. Reversible vs Irreversible ET Reagents 879 E. Categorization of Reagent Strength 881 II. Oxidants 881 A. Inorganic 881 1. Metal and Metal Complex Oxidants 881 2. Main Group Oxidants 887 B. Organic 891 1. Radical Cations 891 2. Carbocations 893 3. Cyanocarbons and Related Electron-Rich Compounds 894

3,432 citations

Journal ArticleDOI
TL;DR: Improvements in Catalytic Systems and Superior Reactivity of N2 as the Nucleofuge 4637 and Related Matsuda−Heck Reactions 4637.
Abstract: 2.1.4. Effect of Bases and Other Additives 4628 2.1.5. Improved Catalytic Systems 4629 2.1.6. Applications in Synthesis 4630 2.1.7. Mechanistic Studies 4632 2.1.8. Related Matsuda−Heck Reactions 4633 2.2. Suzuki−Miyaura Reaction 4634 2.2.1. Early Studies 4634 2.2.2. Modification of the Boronic Counterpart 4635 2.2.3. Improved Catalytic Systems 4637 2.2.4. Superior Reactivity of N2 as the Nucleofuge 4637

668 citations

Patent
Prabha N. Ibrahim1, Wayne Spevak1, Hanna Cho1, Songyuan Shi1, Chao Zhang1, Ying Zhang1 
04 Nov 2010
TL;DR: In this paper, compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described to treat diseases and conditions, including diseases associated with activity of B-Raf V600E mutant protein kinase.
Abstract: Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on at least one Raf protein kinase. In certain aspects and embodiments, the described compounds are active in inhibiting proliferation of a Ras mutant cell line. Also described are methods of use thereof to treat diseases and conditions, including diseases and conditions associated with activity of B-Raf V600E mutant protein kinase, including melanoma, glioma, glioblastoma multiforme, pilocytic astrocytoma, colorectal cancer, thyroid cancer, lung cancer, ovarian cancer, prostate cancer, liver cancer, gallbladder cancer, gastrointestinal stromal tumors, biliary tract cancer, and cholangiocarcinoma. Also described are methods of use thereof to treat diseases and conditions, including diseases and conditions associated with activity of c-Raf-1 protein kinase, including acute pain, chronic pain or polycystic kidney disease.

322 citations

Journal ArticleDOI
TL;DR: Potassium trifluoro(organo)borates, highly stable organoboron derivatives, have recently emerged as promising alternatives to other reagents as discussed by the authors, not only through intermediate formation of difluoroboranes, but also in transmetallation reactions with transition metals.

297 citations