Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions
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...environmental influences, such as abuse or adversities in childhood, have also been linked to stable DNA methylation differences that persist into adulthood (Meaney, 2010; Essex et al., 2011; Borghol et al., 2012; Lam et al., 2012; Klengel et al., 2013)....
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...Other environmental influences, such as abuse or adversities in childhood, have also been linked to stable DNA methylation differences that persist into adulthood (Meaney, 2010; Essex et al., 2011; Borghol et al., 2012; Lam et al., 2012; Klengel et al., 2013)....
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Cites background from "Allele-specific FKBP5 DNA demethyla..."
...Childhood maltreatment produces an FKBP5 genotype-specific demethylation of a distal enhancer, resulting in increased FKBP5 expression, and decreased GR signalling (100)....
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