Open AccessJournal Article
Alterations of Emotional and Cognitive Behaviors in Matrix Metalloproteinase-2 and -9-Deficient Mice
Hiroyuki Mizoguchi,Daisuke Ibi,Kazuhiro Takuma,Yuko Kitahara,Erika Toth,Jun Sato,Shigeyoshi Itohara,Toshitaka Nabeshima,Kiyofumi Yamada +8 more
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TLDR
It is suggested that endogenous MMP-9 play a role in emotional and cognitive behaviors, which may possibly be related to activity- dependent synaptic plasticity and brain development.Abstract:
Matrix metalloproteinases (MMPs) function to remodel the pericellular environment, and thereby play a crucial role in the remodeling of neural circuits. In the present study, we investigated the role of MMP-2 and MMP-9 in emotional and cognitive function using mice with targeted deletions of the MMP-2 and MMP-9 genes. Emotional behaviors of MMP-9-(-/-) mice but not MMP-2-(-/-) mice were altered, which was manifested in performances in the open-field and elevated plus-arm maze tests. MMP-9-(-/-) mice showed impairments in long-term object recognition memory and conditioned fear memory. MMP-2-(-/-) mice had no deficits in learning and memory. These findings suggest that endogenous MMP-9 play a role in emotional and cognitive behaviors, which may possibly be related to activity- dependent synaptic plasticity and brain development.read more
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Matrix metalloproteinase-9 contributes to kindled seizure development in pentylenetetrazole-treated mice by converting pro-BDNF to mature BDNF in the hippocampus
Hiroyuki Mizoguchi,Junya Nakade,Masaki Tachibana,Daisuke Ibi,Daisuke Ibi,Eiichi Someya,Hiroyuki Koike,Hiroyuki Kamei,Toshitaka Nabeshima,Shigeyoshi Itohara,Kazuhiro Takuma,Makoto Sawada,Jun Sato,Kiyofumi Yamada,Kiyofumi Yamada +14 more
TL;DR: MMP-9 is involved in the progression of behavioral phenotypes in kindled mice because of conversion of pro-BDNF to mature BDNF in the hippocampus, which is accompanied by decreased hippocampal levels of mature brain-derived neurotrophic factor.
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Matrix metalloproteinase-2 and -9 as promising benefactors in development, plasticity and repair of the nervous system.
TL;DR: The currently known or suggested actions of M MP-2 and MMP-9 in the developing and adult nervous system and their potential to improve repair or regeneration after nervous system injury are highlighted.
Journal ArticleDOI
Extracellular proteolysis in structural and functional plasticity of mossy fiber synapses in hippocampus.
TL;DR: The role of extracellular proteolysis in various aspects of synaptic plasticity in hippocampal mossy fiber synapses is reviewed, and a growing body of evidence demonstrates that among perisynaptic proteases, tissue plasminogen activator (tPA)/plasmin system, β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) and metalloproteinases play a crucial role in shaping plastic changes in this projection.
Journal ArticleDOI
Fingolimod increases brain-derived neurotrophic factor levels and ameliorates amyloid β-induced memory impairment.
Kazuya Fukumoto,Hiroyuki Mizoguchi,Hideyuki Takeuchi,Hiroshi Horiuchi,Jun Kawanokuchi,Shijie Jin,Tetsuya Mizuno,Akio Suzumura +7 more
TL;DR: It is shown that oral administration of fingolimod ameliorated the impairment in object recognition memory and associative learning in mice injected with amyloid β and was associated with restoration of normal BDNF expression levels in the cerebral cortices and hippocampi, suggesting that neuroprotection was mediated by up-regulation of neuronal BDNF levels.
Journal ArticleDOI
Chronic Hyponatremia Causes Neurologic and Psychologic Impairments
Haruki Fujisawa,Yoshihisa Sugimura,Hiroshi Takagi,Hiroyuki Mizoguchi,Hideyuki Takeuchi,Hisakazu Izumida,Kohtaro Nakashima,Hiroshi Ochiai,Seiji Takeuchi,Atsushi Kiyota,Kazuya Fukumoto,Shintaro Iwama,Yoshiko Takagishi,Yoshitaka Hayashi,Hiroshi Arima,Yukio Komatsu,Yoshiharu Murata,Yutaka Oiso +17 more
TL;DR: The results suggest chronic hyponatremia in humans may cause gait disturbance and cognitive impairment, but these abnormalities are reversible and careful correction of this condition may improve quality of life and reduce mortality.
References
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Journal ArticleDOI
Metalloproteinases in biology and pathology of the nervous system
TL;DR: Some of the beneficial functions of MMPs during neural development are considered and their roles in repair after brain injury are speculated, as well as a family of proteins known as ADAMs, as some of the properties previously ascribed to M MPs are possibly the result of ADAM activity.
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Extracellular Matrix Molecules and their Receptors: Functions in Neural Development
TL;DR: This review focuses on cellular and molecular themes not emphasized in the previous one and includes examples of recent work on nonneural systems that illustrate probable future directions for research in the nervous system.
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Matrix metalloproteinase-9 is required for hippocampal late-phase long-term potentiation and memory.
Vanja Nagy,Ozlem Bozdagi,Anna Matynia,Marcin Balcerzyk,Pawel Okulski,Joanna Dzwonek,Rui M. Costa,Alcino J. Silva,Leszek Kaczmarek,George W. Huntley +9 more
TL;DR: A novel role for MMP-9 is demonstrated in hippocampal synaptic physiology, plasticity, and memory and integrin function-blocking reagents prevent an M MP-9-mediated potentiation of synaptic signal strength.
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Matrix Metalloproteinase-9 Undergoes Expression and Activation during Dendritic Remodeling in Adult Hippocampus
TL;DR: A unique spatiotemporal pattern of MMP-9 expression suggests its involvement in activity-dependent remodeling of dendritic architecture with possible effects on synaptic physiology.
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Unaltered secretion of beta-amyloid precursor protein in gelatinase A (matrix metalloproteinase 2)-deficient mice.
TL;DR: It is shown here that APP is cleaved within the β-amyloid region and secreted into the extracellular milieu of brain and cultured fibroblasts without gelatinase A activity, and the data suggest that gelatin enzyme A does not play an essential role in the generation and release of soluble derivatives of APP at physiological conditions.