Alternative Wnt Signaling Activates YAP/TAZ
Hyun Woo Park,Young Chul Kim,Bo Yu,Toshiro Moroishi,Jung-Soon Mo,Steven W. Plouffe,Zhipeng Meng,Kimberly C. Lin,Fa-Xing Yu,Caroline M. Alexander,Cun-Yu Wang,Kun-Liang Guan +11 more
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TLDR
This work establishes YAP/TAZ as critical mediators of alternative Wnt signaling, including gene expression, osteogenic differentiation, cell migration, and antagonism of Wnt/β-catenin signaling.About:
This article is published in Cell.The article was published on 2015-08-13 and is currently open access. It has received 516 citations till now. The article focuses on the topics: Frizzled & LRP6.read more
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Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer.
TL;DR: The Hippo pathway regulates cell proliferation, apoptosis, and stemness in response to a wide range of extracellular and intracellular signals, including cell-cell contact, cell polarity, mechanical cues, ligands of G-protein-coupled receptors, and cellular energy status.
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YAP/TAZ at the Roots of Cancer
TL;DR: In this paper, a number of cancer-associated extrinsic and intrinsic cues conspire to overrule the YAP-inhibiting microenvironment of normal tissues, including changes in mechanotransduction, inflammation, oncogenic signaling, and regulation of the Hippo pathway.
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Mechanisms of Hippo pathway regulation
TL;DR: This review focuses on recent developments in the understanding of the molecular actions of the core Hippo kinase cascade and discusses key open questions in the regulation and function of the Hippo pathway.
Journal ArticleDOI
Fate decision of mesenchymal stem cells: adipocytes or osteoblasts?
Qing Chen,Qing Chen,Peishun Shou,C Zheng,M Jiang,G Cao,Q Yang,J Cao,N Xie,Tania Velletri,X Zhang,Chunliang Xu,L Zhang,Huilin Yang,J Hou,Ying Wang,Yufang Shi +16 more
TL;DR: External factors and their signaling processes dictating the reciprocal regulation between adipocytes and osteoblasts during MSC differentiation and the ultimate control of the adipo-osteogenic balance are reviewed.
Journal ArticleDOI
YAP/TAZ upstream signals and downstream responses
TL;DR: How the transcriptional regulators YAP and TAZ integrate mechanical cues with the response to soluble signals and metabolic pathways to control multiple aspects of cell behaviour, including proliferation, cell plasticity and stemness essential for tissue regeneration is reviewed.
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