Alzheimer's disease as homeostatic responses to age-related myelin breakdown
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Cites background from "Alzheimer's disease as homeostatic ..."
...Bartzokis goes even as far as to propose that the recently evolved extensive myelination of the human brain explains increased vulnerability to neurodegenerative and neuropsychiatric disorders (Bartzokis, 2011)....
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...This cellular loss is reflected in age-associated myelin breakdown as seen in MRI scans of patients from age 50 on (Bartzokis, 2011)....
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...Later differentiating oligodendrocytes en-sheath more axons with small axon diameters as seen in late myelinating frontal and temporal lobes (Bartzokis, 2011), and it might be that these make these areas more vulnerable to all kinds of stresses....
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...One of the more compelling arguments to increase focus on oligodendrocytes and possible demyelination is the strongly accentuated age-related breakdown of myelin in AD and in APOE4 patients (Bartzokis, 2011; Scheltens et al., 1992)....
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...Age-related myelin breakdown as assessed byMRImight indeed result in a progressive disconnection of neural networks and presage AD (Bartzokis, 2011)....
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580 citations
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Cites background from "Alzheimer's disease as homeostatic ..."
...…potentially provide important information for assessing, e.g. multiple sclerosis (Inglese and Bester, 2010; Warlop et al., 2009, 2008), Alzheimer's disease (Bartzokis, 2011), and other neuro-psychiatric and/or neuro-degenerative disorders that may be related to myelin dysfunction (Nave, 2010)....
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..., 2009, 2008), Alzheimer's disease (Bartzokis, 2011), and other neuro-psychiatric and/or neuro-degenerative disorders that may be related to myelin dysfunction (Nave, 2010)....
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417 citations
References
12,652 citations
"Alzheimer's disease as homeostatic ..." refers background in this paper
...…myelin model can be exemplified by briefly considring it in the context of recent modifications to the AH. ncreased amyloid A deposition is the ultimate manifestaion of known forms of FAD and is an important process in he pathogenesis of AD (Hardy and Selkoe, 2002; Selkoe, 999; Thal et al., 2002)....
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"Alzheimer's disease as homeostatic ..." refers background in this paper
...This modication suggests that before their deposition into neuritic laques, soluble oligomeric forms of A cause synapse loss nd/or interfere with long-term potentiation (LTP) of synapic transmission that underlies memory formation (Selkoe, 002, 2008; Shankar et al., 2008; Townsend et al., 2006)....
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...Released A aggregates can bind to receptors (that ay mediate synaptic toxicity, Lauren et al., 2009; Selkoe, 008; Shankar et al., 2008) as well as lipids and cholesterol Avdulov et al., 1997; Small et al., 2007) and thus may also be oxic to myelin given its extreme cholesterol content (Muse et l.,…...
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...…essential role in cognition and memory and evidence that hese structures can be lost when exposed to A oligomers Lacor et al., 2007; Selkoe, 2008; Shankar et al., 2008). ynapses are however extremely “plastic” (routinely lost and eacquired, McEwen et al., 2001; Radley et al., 2008), are lost n a…...
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