Alzheimer's disease drug development pipeline: 2017
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Cites background from "Alzheimer's disease drug developmen..."
...Eight agents listed in phase III in 2017 [7] failed in clinical trials as of January 30, 2018....
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...A few new agents have entered the pipeline when compared with the 2017 review [7]: there are eight new agents in phase I, 14 in phase II, and four in phase III....
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...In this update of our annual review of the AD drug development pipeline, we provide a summary of the current state of progress in developing new therapies for AD [6,7]....
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Cites background or methods from "Alzheimer's disease drug developmen..."
...Since the systematic review conducted by Cummings and colleagues in January 2017 [393], Merck has halted its phase II and III trials of the BACE inhibitor verubescestat for lack of efficacy; a leading theory for this failure is the timing of treatment [399]....
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...This was published in Alzheimers Dementia (N Y), 2017, 3(3): 367-384 [393], under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License (CC BY NC ND) https://creativecommons....
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...However, this category comprises more than half (57%) of phase III AD trials [393]....
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...gov conducted in January 2017 by Cummings and colleagues [393]....
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References
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"Alzheimer's disease drug developmen..." refers background in this paper
...Aducanumab targets multiple Ab species, has had an encouraging phase I/II trial, and is continuing in phase III [35]....
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1,399 citations
"Alzheimer's disease drug developmen..." refers background in this paper
...Although there are promising agents in the pipeline that could achieve this goal, it is clear that given the high rate of failure of AD drug development [38], the aim of having a repertoire of agents that could respond comprehensively and individually to a patient’s clinical circumstances within the 2025 timeframe is in jeopardy....
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