Journal ArticleDOI
Amide bond formation and peptide coupling
Reads0
Chats0
TLDR
In this article, the authors propose a method to solve the problem of "uniformity" in the literature: 1.0040−4020/$ doi:10.1016/About:
This article is published in Tetrahedron.The article was published on 2005-11-14. It has received 1581 citations till now. The article focuses on the topics: Peptide bond & Isopeptide bond.read more
Citations
More filters
Journal ArticleDOI
The Medicinal Chemist's Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates
TL;DR: The reaction types used in the pursuit of novel drug candidates are analyzed to evaluate their frequency of occurrence, alongside other factors such as drug likeness, chirality, and the number of steps to each derivative.
Journal ArticleDOI
Amide bond formation: beyond the myth of coupling reagents
Eric Valeur,Mark Bradley +1 more
TL;DR: This critical review is focussed on the most recently developed coupling reagents with particular attention paid to the pros and cons of the plethora of "acronym" based reagents.
Journal ArticleDOI
Synthesis and applications of Rhodamine derivatives as fluorescent probes
TL;DR: In this critical review the strategies for modification of Rhodamine dyes and a discussion on the variety of applications of these new derivatives as fluorescent probes are given.
Journal ArticleDOI
Peptide coupling reagents, more than a letter soup
TL;DR: Peptide Coupling Reagents, More than a Letter Soup Ayman El-Faham* and Fernando Albericio* Institute for Research in Biomedicine, Barcelona Science Park, Baldiri Reixac 10, 08028-Barcelona, Spain.
Journal ArticleDOI
Contemporary strategies for peptide macrocyclization
TL;DR: Recent solutions to some of the major challenges in this important area of contemporary synthesis of peptide macrocycles are reviewed.
References
More filters
Book
Vogel's Textbook of Practical Organic Chemistry
Arthur I. Vogel,Brian S. Furniss +1 more
TL;DR: In this paper, the authors present a method for the synthesis of organic compounds using Spectroscopic methods and Spectral Spectral Methods (SSTM) with a focus on alicyclic and aliphatic compounds.
Journal ArticleDOI
Controlled microwave heating in modern organic synthesis.
TL;DR: This Review highlights recent applications of controlled microwave heating in modern organic synthesis, and discusses some of the underlying phenomena and issues involved.
Journal ArticleDOI
A knowledge-based approach in designing combinatorial or medicinal chemistry libraries for drug discovery. 1. A qualitative and quantitative characterization of known drug databases.
TL;DR: The effective range of physicochemical properties presented here can be used in the design of drug-like combinatorial libraries as well as in developing a more efficient corporate medicinal chemistry library.
Book
March's Advanced Organic Chemistry: Reactions, Mechanisms, and Structure, 5th Edition
Shu-Kun Lin,Jerry March +1 more
TL;DR: The Literature of Organic Chemistry, Volume One: Reactions by Type of Compound Synthesized Indexes, and Substitution Reactions: Free Radicals is published.
Book
Fmoc solid phase peptide synthesis : a practical approach
Weng C. Chan,Peter D. White +1 more
TL;DR: Introduction - a retrospective viewpoint White & Chan: Basic Principles Chan & White: Basic Procedures Albericio et al: Preparation and Handling of Peptides Containing Methionine and Cysteine