Ampicillin Plus Ceftriaxone Is as Effective as Ampicillin Plus Gentamicin for Treating Enterococcus faecalis Infective Endocarditis
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Cites background or result from "Ampicillin Plus Ceftriaxone Is as E..."
...First, these are the largest series of E faecalis IE reported to date, 43 patients in 1 study(190) and 272 in the other study.(191) Second, high-level aminoglycoside-resistant E faecalis IE treated with ampicillin-ceftriaxone therapy was present in 50% of the patients in the smaller study and 33% of patients in the larger study....
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...A large, multicenter study by Spanish and Italian investigators compared ampicillin-ceftriaxone with ampicillin-gentamicin therapy of E faecalis IE.(191) Patients with high-level aminoglycoside-resistant strains were not treated with ampicillin-gentamicin....
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Cites background from "Ampicillin Plus Ceftriaxone Is as E..."
...Seemingly redundant therapy, such as the combination of the b-lactams, ampicillin and ceftriaxone, has been shown clinically to be as efficacious as more traditional combinations with aminoglycosides, with the benefit of less toxicity and the ability to bypass high-level resistance to aminoglycosides [133,134]....
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387 citations
Cites background from "Ampicillin Plus Ceftriaxone Is as E..."
...effective as ampicillin/gentamicin, with reduced levels of nephrotoxicity (94,95)....
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