Amyloid negativity in patients with clinically diagnosed Alzheimer disease and MCI
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...This latter biomarker profile implies evidence of one or more neuropathologic processes other than AD [35,40,107] and has been labeled “suspected non-Alzheimer’s pathophysiology” (or SNAP) [38]....
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Cites background from "Amyloid negativity in patients with..."
...ADNI cohort, were reported to be Ab2 on florbetapir PET [100]....
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...Rates of cognitive and functional decline, cortical Ab deposition (florbetapir PET), temporal lobe atrophy, and neuronal injury (FDG-PET) all accelerated before the conventional threshold of CSF Ab positivity (Fig....
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...Wolz et al. [174] operationalized the 2011 NIA-AA diagnostic criteria for MCI due to AD [155]—namely Ab positivity (florbetapir PET) plus a marker of neurodegeneration (in this case hippocampal volume)—as inclusion criteria for clinical trials....
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...A discordant status (CSF1/PET2) may indicate early deposition of Ab pathology [34], but even earlier depositionmay be indicated by conversion of participants with no measurable signs of Ab accumulation (CSF2/PET2) to an Ab discor- dant status (CSF1/PET2) [35]....
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...Consistent with previous pathology reports, greater binding of this ligand was observed in Ab1 (by florbetapir PET) than Ab2 participants across the disease spectrum [58]....
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"Amyloid negativity in patients with..." refers methods in this paper
...We examined several clinical and cognitive performance measurements including baseline and longitudinal performance on the Mini-Mental State Examination (MMSE),(22) the Functional Assessment Questionnaire,(23) the Rey Auditory Verbal Learning Test (RAVLT),(24) and Alzheimer’s Disease Assessment Scale–cognitive subscale (ADAS-cog).(25) We also examined baseline scores on the Geriatric Depression Scale(26) although this test was used as a screening tool for ADNI enrollment; participants with a score higher than 5 at baseline were excluded....
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