An Euler Path Based Online Testing Technique to Detect Catastrophic Fault in Triangular DMFBs
01 Jan 2018-Vol. 24, pp 531-539
TL;DR: A graph-based test planning technique for online testing is proposed in this paper and it focuses on Euler path based test technique for catastrophic fault detection ofective microfluidic chip.
Abstract: Defective microfluidic chip increases the assay completion and total turnaround time and it is the main reason of deviation of the actual result of assay operation. In online testing, the test droplets are moving out of step with each other. Again testing of DMFB is NP-hard in nature. Using Euler path based test technique, we can test the whole chip but we cannot apply Hamiltonian path based test method in case of equilateral triangular electrode array due to routing constraints in triangular DMFB. A graph-based test planning technique for online testing is proposed in this paper. Considering the active parts of the chip, like mixer and store cell, as obstacle in the triangular microfluidic array, we test the chip during the assay operation running in some portions of the array. Here, we focus on Euler path based test technique for catastrophic fault detection.
TL;DR: To understand the opportunities and limitations of EWD microfluidics, this paper looks at the development of lab-on-chip applications in a hierarchical approach.
Abstract: The suitability of electrowetting-on-dielectric (EWD) microfluidics for true lab-on-a-chip applications is discussed. The wide diversity in biomedical applications can be parsed into manageable components and assembled into architecture that requires the advantages of being programmable, reconfigurable, and reusable. This capability opens the possibility of handling all of the protocols that a given laboratory application or a class of applications would require. And, it provides a path toward realizing the true lab-on-a-chip. However, this capability can only be realized with a complete set of elemental fluidic components that support all of the required fluidic operations. Architectural choices are described along with the realization of various biomedical fluidic functions implemented in on-chip electrowetting operations. The current status of this EWD toolkit is discussed. However, the question remains: which applications can be performed on a digital microfluidic platform? And, are there other advantages offered by electrowetting technology, such as the programming of different fluidic functions on a common platform (reconfigurability)? To understand the opportunities and limitations of EWD microfluidics, this paper looks at the development of lab-on-chip applications in a hierarchical approach. Diverse applications in biotechnology, for example, will serve as the basis for the requirements for electrowetting devices. These applications drive a set of biomedical fluidic functions required to perform an application, such as cell lysing, molecular separation, or analysis. In turn, each fluidic function encompasses a set of elemental operations, such as transport, mixing, or dispensing. These elemental operations are performed on an elemental set of components, such as electrode arrays, separation columns, or reservoirs. Examples of the incorporation of these principles in complex biomedical applications are described.
•10 Oct 2006
TL;DR: A new book enPDFd digital microfluidic biochips synthesis testing and reconfiguration techniques to read, offering new opportunities to read and to support reading.
Abstract: Let's read! We will often find out this sentence everywhere. When still being a kid, mom used to order us to always read, so did the teacher. Some books are fully read in a week and we need the obligation to support reading. What about now? Do you still love reading? Is reading only for you who have obligation? Absolutely not! We here offer you a new book enPDFd digital microfluidic biochips synthesis testing and reconfiguration techniques to read.
TL;DR: A parallel scan-like testing methodology for digital microfluidic devices and a diagnosis method based on test outcomes is proposed, enhanced such that multiple defect sites can be efficiently located using parallel scan -like testing.
Abstract: Dependability is an important attribute for microfluidic biochips that are used for safety-critical applications such as point-of-care health assessment, air-quality monitoring, and food-safety testing. Therefore, these devices must be adequately tested after manufacture and during bioassay operations. We propose a parallel scan-like testing methodology for digital microfluidic devices. A diagnosis method based on test outcomes is also proposed. The diagnosis technique is enhanced such that multiple defect sites can be efficiently located using parallel scan-like testing. Defect diagnosis can be used to reconfigure a digital microfluidic biochip such that faults can be avoided, thereby enhancing chip yield and defect tolerance. We evaluate the proposed method using complexity analysis as well as applying it to a fabricated biochip.
TL;DR: This paper addresses fundamental biochip operations, such as droplet dispensing, droplet transportation, mixing, splitting, and capacitive sensing, and evaluates the proposed test methods using simulations as well as experiments for a fabricated biochip.
Abstract: Dependability is an important attribute for microfluidic biochips that are used for safety-critical applications, such as point-of-care health assessment, air-quality monitoring, and food-safety testing. Therefore, these devices must be adequately tested after manufacture and during bioassay operations. Known techniques for biochip testing are all function oblivious (i.e., while they can detect and locate defect sites on a microfluidic array, they cannot be used to ensure correct operation of functional units). In this paper, we introduce the concept of functional testing of microfluidic biochips. We address fundamental biochip operations, such as droplet dispensing, droplet transportation, mixing, splitting, and capacitive sensing. Long electrode actuation times are avoided to ensure that there is no electrode degradation during testing. The functional testing of pin-constrained biochips is also studied. We evaluate the proposed test methods using simulations as well as experiments for a fabricated biochip.
•03 May 2010
TL;DR: This book uses real-life bioassays as examples to lay out an automated design flow for creating microfluidic biochips and presents specialized pinconstrained design techniques for making bioch chips with a focus on cost and disposability.
Abstract: Microfluidics-based biochips combine electronics with biochemistry, providing access to new application areas in a wide variety of fields. Continued technological innovations are essential to assuring the future role of these chips in functional diversification in biotech, pharmaceuticals, and other industries.Revolutionary guidance on design, opti
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