An immune clock of human pregnancy.
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Cites background from "An immune clock of human pregnancy...."
...Innate immune cells, such as NK cells and monocytes, respond more strongly to viral challenges, while some adaptive immune responses are down-regulated during pregnancy, e.g. decreased numbers of T and B cells (Aghaeepour et al., 2017) ....
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...Recently, Aghaeepour and colleagues (Aghaeepour et al., 2017 ) suggested a precise timing of immunological events in peripheral blood that occurred during full-term pregnancy, named "immune clock."...
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References
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"An immune clock of human pregnancy...." refers methods in this paper
...An L1 regularization (38) was applied on the b coefficients to reduce the model complexity, such that L(b) = |Y − Xb|(2) + l1|b|1, where l1 is selected by cross-validation....
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30,124 citations
27,271 citations
"An immune clock of human pregnancy...." refers methods in this paper
...The four freeparameters of themodel (l1,l2 ,φ, andy)wereoptimized using a gradient-free optimization algorithm (39)....
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16,538 citations
"An immune clock of human pregnancy...." refers background or methods in this paper
...The csEN algorithmwas adapted from the Elastic Net (EN) regularized regression method (18) and accounts for the influence of previous biological knowledge of receptor-specific signal transduction on the generation of single-cell mass cytometry data....
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...This limitation is addressed by using an additionalL2 regularization (18) to allow the inclusion of highly correlated measurements: L(b) = |Y − Xb|(2) + l1|b|1 + l2|b|2, where l1 and l2 are selected by cross-validation....
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...Statistical analysis Multivariate modeling of mass cytometry data using a cell signaling–based matrix The csEN algorithm was adapted from the existing EN algorithm (18) to allow accounting for the influence of previous knowledge of intracellular signal transduction on the generation of the mass cytometry data set....
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...The highly correlated nature of the mass cytometry data suggested an EN method—a regularized regression method particularly suitable to the analysis of intercorrelated data (18)—as a primary candidate to determine whether dynamic changes occurring in peripheral immune cells during pregnancy could predict gestational age at time of sampling....
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2,273 citations
"An immune clock of human pregnancy...." refers background in this paper
...Community 16, anchored in the csEN component “pSTAT1 response to IFN-a in CD16CD56NK cells,” was primarily populated by immune features related to STAT1 tyrosine phosphorylation in response to IFN-a, an essential pathway for type-I IFN signal transduction (23)....
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