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Journal ArticleDOI

An in-Depth Analysis of the Swelling, Mechanical, Electrical, and Drug Release Properties of Agar–Gelatin Co-Hydrogels

TL;DR: Though the firmness of the co-hydrogels was higher, Weichert model of viscoelasticity indicated that the inherent mechanical stability of the gelatin hydrogel was superior.
Abstract: Agar–gelatin-based co-hydrogels were prepared with different compositions of the agar and the gelatin fractions. The intermolecular hydrogen bonding was higher in the co-hydrogels as compared to the gelatin hydrogel. Swelling studies indicated diffusion-mediated swelling. The electrical stability of the co-hydrogels was higher as compared to the gelatin hydrogel. Though the firmness of the co-hydrogels was higher, Weichert model of viscoelasticity indicated that the inherent mechanical stability of the gelatin hydrogel was superior. The release of ciprofloxacin hydrochloride was predominately Fickian diffusion-mediated. In gist, the co-hydrogels can be tried as polymeric constructs for controlled drug delivery applications.
Citations
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Journal ArticleDOI
TL;DR: There are limited applications of stimulus-responsive hydrogel in food field, which needs to be further explored, and a variety of response methods that have been developed, including temperature, pH, chemical, optical, electrical and other responsive hydrogels are identified.

39 citations

Journal ArticleDOI
TL;DR: In this paper , a review of stimulus-responsive hydrogels in the field of food is presented, and the current and future applications of these hydrogel in food field are discussed.

34 citations

Journal ArticleDOI
TL;DR: Comprehensive understanding of polymeric behaviour during swelling affords greater control in the design of targeted delivery matrices for drugs and other bioactive compounds.

9 citations

Journal ArticleDOI
J. Campos1, Davide Cunha1, Domingos Ferreira1, Salette Reis1, Paulo Costa1 
TL;DR: Regrading critical factors, Carbopol® increased films' elasticity and flexibility, mucoadhesion, and the strength of the hydrogels, while higher concentrations led to thicker, more opaque, and lower strain resistance products.

9 citations

References
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Journal ArticleDOI
TL;DR: The composition and synthesis of hydrogels, the character of their absorbed water, and permeation of solutes within their swollen matrices are reviewed to identify the most important properties relevant to their biomedical applications.

5,173 citations


"An in-Depth Analysis of the Swellin..." refers background in this paper

  • ...Hydrogels are polymeric architecture which can hold water within its structure([1])....

    [...]

Journal ArticleDOI
TL;DR: The preparation and properties of innovative chitosan-based biomaterials, with respect to their future applications, are highlighted, with a special focus on wound healing application.

1,694 citations

Book ChapterDOI
01 Aug 2011
TL;DR: This chapter reviews the preparation methods of hydrogels from hydrophilic polymers of synthetic and natural origin with emphasis on water soluble natural biopolymers (hydrocolloids).
Abstract: The terms gels and hydrogels are used interchangeably by food and biomaterials scientists to describe polymeric cross-linked network structures. Gels are defined as a substantially dilute cross-linked system, and are categorised principally as weak or strong depending on their flow behaviour in steady-state (Ferry, 1980). Edible gels are used widely in the food industry and mainly refer to gelling polysaccharides (i.e. hydrocolloids) (Phillips & Williams, 2000). The term hydrogel describes three-dimensional network structures obtained from a class of synthetic and/or natural polymers which can absorb and retain significant amount of water (Rosiak & Yoshii, 1999). The hydrogel structure is created by the hydrophilic groups or domains present in a polymeric network upon the hydration in an aqueous environment. This chapter reviews the preparation methods of hydrogels from hydrophilic polymers of synthetic and natural origin with emphasis on water soluble natural biopolymers (hydrocolloids). Recent advances in radiation cross-linking methods for the preparation of hydrogel are particularly addressed. Additionally, methods to characterise these hydrogels and their proposed applications are also reviewed.

353 citations


"An in-Depth Analysis of the Swellin..." refers background in this paper

  • ..., agar, gelatin, κ-carrageenan, sodium caseinate, and b-glucan) are easily available in nature and are cost-effective for developing formulations of commercial interest([6,7])....

    [...]

Journal ArticleDOI
TL;DR: In this article, the composition, structure and rheological properties of a soluble sulfated polysaccharide from Gracilaria cornea (Brazilian red marine alga) were investigated.

267 citations


"An in-Depth Analysis of the Swellin..." refers background in this paper

  • ...In addition to the peaks associated with gelatin molecules, the co-hydrogels also showed peaks associated with agarocolloids (1,370, 1,250, and 1,070 cm (1))([33])....

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Journal ArticleDOI
TL;DR: Some of the most frequently used proteins for tissue engineering and biomedical applications are addressed and the techniques most commonly used to functionalize protein-based biomaterials by combining them with bioactive molecules to enhance biological performance are described.

235 citations