An induction heating device using planar coil with high amplitude alternating magnetic fields for magnetic hyperthermia.
TL;DR: The results demonstrate that the induction heating device can be applied not only to in vitro and in small animal experiments of magnetic hyperthermia using MNPs, but also in large animal experiments.
Abstract: Background Induction heating devices using the induction coil and magnetic nanoparticles (MNPs) are the way that the magnetic hyperthermia is heading. Objective To facilitate the induction heating of in vivo magnetic nanoparticles in hyperthermia experiments on large animals. Methods An induction heating device using a planar coil was designed with a magnetic field frequency of 328 kHz. The coil's magnetic field distribution and the device's induction heating performance on different concentrations of magnetic nanoparticles were measured. Results The alternating magnetic field produced in the axis position 165 mm away from the coil center is 40 Gs in amplitude; magnetic nanoparticles with a concentration higher than 80 mg. mL-1 can be heated up rapidly. Conclusion Our results demonstrate that the device can be applied not only to in vitro and in small animal experiments of magnetic hyperthermia using MNPs, but also in large animal experiments.
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TL;DR: The design and evaluation of a versatile system which provides different experimental setup possibilities for magnetic hyperthermia is reported, a derivative of the Mazzilli inverter which directly follows the resonant frequency of the LC tank circuit independent of its component.
Abstract: In recent decades, magnetic hyperthermia using magnetic nanoparticles, a promising but quite challenging method, has proven to be an effective cancer therapy procedure. In hyperthermia, heat, which is generated by magnetic nanoparticles exposed to a radiofrequency magnetic field, is employed to battle cancerous cells. Ideally, devices for magnetic hyperthermia should provide a variety of field amplitudes and frequencies for generating an appropriate and powerful alternating magnetic field. Here, we report the design and evaluation of a versatile system which provides different experimental setup possibilities for magnetic hyperthermia. The proposed system is a derivative of the Mazzilli inverter, which directly follows the resonant frequency of the LC tank circuit independent of its component. The feasibility of the system for hyperthermia studies was examined using iron oxide nanoparticles prepared by the coprecipitation method. Different experimental conditions including nanoparticles in solution and dispersed in gelatin phantoms were evaluated. Four different coils including two solenoids, a pancake, and a Helmholtz-like format were successfully tested. Using these coils, 18 different operation frequencies in the frequency band of 63–530 kHz with field strengths up to 27.2 kA/m were achieved.
14 citations
TL;DR: A scanning system for specific absorption rate of ferrofluids with superparamagnetic nanoparticles is presented and analyzes the dependence of the power absorption density with the magnetic field intensity and frequency.
Abstract: A scanning system for specific absorption rate of ferrofluids with superparamagnetic nanoparticles is presented in this study. The system contains an induction heating device designed and built with a resonant inverter in order to generate magnetic field amplitudes up to 38 mT, over the frequency band 180-525 kHz. Its resonant circuit involves a variable capacitor with 1 nF of capacitance steps to easily select the desired frequency, reaching from 0.3 kHz/nF up to 5 kHz/nF of resolution. The device performance is characterized in order to compare with the theoretical predictions of frequency and amplitude, showing a good agreement with the resonant inverters theory. Additionally, the setup is tested using a synthetic iron oxide with 10 ± 1 nm diameter suspended in liquid glycerol, with concentrations at 1%. Meanwhile, the temperature rise is measured to determine the specific absorption rate and calculate the dissipated power density for each f. This device is a suitable alternative to studying ferrofluids and analyzes the dependence of the power absorption density with the magnetic field intensity and frequency.
11 citations
TL;DR: In this paper, a frequency tuner system was developed for generating variable frequency magnetic fields for magnetic hyperthermia applications, which can be adapted for other resonant inverters employed in the studies of ferrofluids with superparamagnetic nanoparticles.
Abstract: In this study, a frequency tuner system is developed for generating variable frequency magnetic fields for magnetic hyperthermia applications. The tuning device contains three specially designed phase lock loop devices that drive a resonant inverter working in the frequency band of 180–525 kHz. This tuner system can be adapted for other resonant inverters employed in the studies of ferrofluids with superparamagnetic nanoparticles. The performance of the whole system is also examined. Our findings were in agreement with the theoretical expectations of phase locking and frequency tuning. The system is tested for samples of a solid magnetic material of cylindrical shape and ferrofluids with differing concentrations of powdered magnetite. The observations indicate significant frequency changes of the magnetic field due to heating of the samples. These frequency variations can be a source of errors, which should not be neglected in experiments determining the specific absorption rate or power dissipated density.
8 citations
TL;DR: This review paper directs the interest toward hyperthermia with magnetic nanoparticles and transcranial magnetic stimulation, together with a brief mention of magnetic resonance imaging, and deeply review the technological solutions that have appeared so far in the literature to shape and control the radio frequency magnetic field distribution within biological tissues, highlighting human applications.
Abstract: In recent years, the usage of radio frequency magnetic fields for biomedical applications has increased exponentially. Several diagnostic and therapeutic methodologies exploit this physical entity such as, for instance, magnetic resonance imaging, hyperthermia with magnetic nanoparticles and transcranial magnetic stimulation. Within this framework, the magnetic field focusing and shaping, at different depths inside the tissue, emerges as one of the most important challenges from a technological point of view, since it is highly desirable for improving the effectiveness of clinical methodologies. In this review paper, we will first report some of the biomedical practices employing radio frequency magnetic fields, that appear most promising in clinical settings, explaining the underneath physical principles and operative procedures. Specifically, we direct the interest toward hyperthermia with magnetic nanoparticles and transcranial magnetic stimulation, together with a brief mention of magnetic resonance imaging. Additionally, we deeply review the technological solutions that have appeared so far in the literature to shape and control the radio frequency magnetic field distribution within biological tissues, highlighting human applications. In particular, volume and surface coils, together with the recent raise of metamaterials and metasurfaces will be reported. The present review manuscript can be useful to fill the actual gap in the literature and to serve as a guide for the physicians and engineers working in these fields.
5 citations
TL;DR: A new method to remove biofoulants via induction heating on a modified membrane with magnetite (Fe3 O4) magnetic nanoparticle (MNPs) coating is developed, capable of cleaning bio-foulant for several cycles without damaging the filtration function of the membrane.
Abstract: Filter membrane processes are water purification methods that use a partially permeable membrane to separate contaminants from drinking water and wastewater. Although highly effective, they suffer ...
5 citations
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TL;DR: In this paper, the authors present a review of the current state of the art and some of the future perspectives supported by advanced methods of the so-called nanotechnology, taking this increasing clinical experience carefully into account together with the huge amount of new biological data on heat response of cells and tissues, the approach of magnetic fluid hyperthermia (MFH) is nowadays more promising than ever before.
1,433 citations
"An induction heating device using p..." refers background in this paper
...Keywords: Magnetic hyperthermia, magnetic nanoparticles, planar coil, power abortion, induction heating...
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TL;DR: A progress report on the biomedical applications of magnetic nanoparticles since 2003 is presented in this paper, with a focus on magnetic actuation for in vitro non-viral transfection and tissue engineering.
Abstract: A progress report is presented on a selection of scientific, technological and commercial advances in the biomedical applications of magnetic nanoparticles since 2003. Particular attention is paid to (i) magnetic actuation for in vitro non-viral transfection and tissue engineering and in vivo drug delivery and gene therapy, (ii) recent clinical results for magnetic hyperthermia treatments of brain and prostate cancer via direct injection, and continuing efforts to develop new agents suitable for targeted hyperthermia following intravenous injection and (iii) developments in medical sensing technologies involving a new generation of magnetic resonance imaging contrast agents, and the invention of magnetic particle imaging as a new modality. Ongoing prospects are also discussed.
1,315 citations
TL;DR: In this paper, the specific loss power of magnetic nanoparticles for hyperthermia was investigated with respect to optimization of the SLP for application in tumour hyper-thermia and the dependence of the loss power on the mean particle size was studied over a broad size range from superparamagnetic up to multidomain particles.
Abstract: Loss processes in magnetic nanoparticles are discussed with respect to optimization of the specific loss power (SLP) for application in tumour hyperthermia. Several types of magnetic iron oxide nanoparticles representative for different preparation methods (wet chemical precipitation, grinding, bacterial synthesis, magnetic size fractionation) are the subject of a comparative study of structural and magnetic properties. Since the specific loss power useful for hyperthermia is restricted by serious limitations of the alternating field amplitude and frequency, the effects of the latter are investigated experimentally in detail. The dependence of the SLP on the mean particle size is studied over a broad size range from superparamagnetic up to multidomain particles, and guidelines for achieving large SLP under the constraints valid for the field parameters are derived. Particles with the mean size of 18 nm having a narrow size distribution proved particularly useful. In particular, very high heating power may be delivered by bacterial magnetosomes, the best sample of which showed nearly 1 kW g −1 at 410 kHz and 10 kA m −1 . This value may even be exceeded by metallic magnetic particles, as indicated by measurements on cobalt particles.
919 citations
"An induction heating device using p..." refers background in this paper
...In order to quickly reach the temperature 46◦C [7,28,29], we recommend that the concentration of the particles greater than 80 mg·mL−1....
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...The more uniform the magnetic field was, the better the temperature stability of MNPs was [28]....
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TL;DR: In this article, a new AC magnetic field therapy system for clinical application of magnetic fluid hyperthermia (MFH) is described with optimized magnetic nanoparticle preparations it will be used for target-specific glioblastoma and prostate carcinoma therapy.
689 citations
"An induction heating device using p..." refers background in this paper
...In order to quickly reach the temperature 46◦C [7,28,29], we recommend that the concentration of the particles greater than 80 mg·mL−1....
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...Keywords: Magnetic hyperthermia, magnetic nanoparticles, planar coil, power abortion, induction heating...
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TL;DR: The emerging roles of nanoparticles, especially gold, in the hyperthermic treatment of cancer and the similarities of radiofrequency ablation and nanoparticle mediated cytotoxicity are discussed.
510 citations