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An Insight on the Swelling, Viscoelastic, Electrical, and Drug Release Properties of Gelatin–Carboxymethyl Chitosan Hydrogels

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TLDR
The results suggested the potential use of the hydrogels as drug delivery matrices, which were predominantly Fickian diffusion mediated and released in its active form.
Abstract
The present study reports the in-depth analysis of the gelatin–carboxymethyl chitosan hydrogels. The composite system formed phase-separated hydrogels, which is confirmed by scanning electron microscopy. The swelling of the carboxymethyl chitosan-containing hydrogels was lower than the gelatin hydrogel. Macroscale deformation study using a static mechanical tester indicated a viscoelastic nature of the hydrogels. A decrease in the impedance of the hydrogels was observed with an increase in the carboxymethyl chitosan content. The drug release from the hydrogels was predominantly Fickian diffusion mediated and was released in its active form. The results suggested the potential use of the hydrogels as drug delivery matrices.

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Oromucosal precursors of in loco hydrogels for wound-dressing and drug delivery in oral mucositis: Retain, resist, and release.

TL;DR: Regrading critical factors, Carbopol® increased films' elasticity and flexibility, mucoadhesion, and the strength of the hydrogels, while higher concentrations led to thicker, more opaque, and lower strain resistance products.
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Swelling and dye adsorption properties of polyelectrolyte semi-IPNs including of acrylamide/(3-acrylamidopropyl)trimethyl ammonium chloride/poly(ethylene glycol)

TL;DR: In this article, the preparation, characterization, and application of acrylamide-based cross-linked polymers as a synthetic sorbent materials for anionic dye calconcarboxylic acid (CCA) was described.
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Effect of Tamarind Gum on the Properties of Phase-Separated Poly(vinyl alcohol) Films

TL;DR: In this article , the effect of tamarind gum (TG) on the optical, mechanical, and drug release potential of polyvinyl alcohol (PVA)-based films was evaluated.
References
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Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC).

TL;DR: The present article is a comprehensive review of the current state of the art of mathematical modeling drug release from HPMC-based delivery systems and discusses the crucial points of the most important theories.
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Natural and synthetic polymers for wounds and burns dressing

TL;DR: Biocompatible with fibroblasts and keratinocytes, tissue engineered skin is indicated for regeneration and remodeling of human epidermis and wound healing improving the treatment of severe skin defects or partial-thickness burn injuries.
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Graphene hydrogels deposited in nickel foams for high-rate electrochemical capacitors.

TL;DR: Graphene hydrogel/nickel foam composite electrodes for high-rate electrochemical capacitors are produced by reduction of an aqueous dispersion of graphene oxide in a nickel foam and exhibits highrate performance.
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A biomimetic extracellular matrix for cartilage tissue engineering centered on photocurable gelatin, hyaluronic acid and chondroitin sulfate.

TL;DR: The addition of HA-MA to Gel-MA constructs resulted in more rounded cell morphologies, enhanced chondrogenesis as assessed by gene expression and immunofluorescence, and increased quantity and distribution of the newly synthesized extracellular matrix (ECM) throughout the construct.
Journal ArticleDOI

Viscoelastic properties of isolated collagen fibrils.

TL;DR: Stress-strain-time data indicate that isolated fibrils exhibit viscoelastic behavior that could be fitted using the Maxwell-Weichert model, and the only statistically significant difference found was that the elastic modulus is larger in the first test than in the subsequent two tests, indicating that viscous properties of collagen fibril are not sensitive to the history of previous tests.
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The mechanical properties of carboxymethyl chitosan hydrogels, degree of carboxymethylation?

The carboxymethyl chitosan hydrogels exhibited viscoelastic behavior, with lower swelling compared to gelatin hydrogels. The degree of carboxymethylation influenced the electrical properties and drug release mechanism.