Journal ArticleDOI
An intact protein translocating machinery is required for mitochondrial import of a yeast cytoplasmic tRNA.
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TLDR
It is demonstrated that a functional mitochondrial protein translocation apparatus is required for the mitochondrial import of the yeast tRNA(LysCUU), the only nuclear-coded tRNA species to be mitochondrially-imported.About:
This article is published in Journal of Molecular Biology.The article was published on 1995-01-27. It has received 121 citations till now. The article focuses on the topics: Translocase of the inner membrane & Inner mitochondrial membrane.read more
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Journal ArticleDOI
Protein import into mitochondria.
TL;DR: Molecular chaperones in the matrix exert multiple functions in translocation, sorting, folding, and assembly of newly imported proteins.
Journal ArticleDOI
Mitochondrial membrane potential.
Ljubava D. Zorova,Vasily A. Popkov,Egor Y. Plotnikov,Denis N. Silachev,Irina B. Pevzner,S. S. Jankauskas,V. A. Babenko,S. D. Zorov,Anastasia V. Balakireva,Magdalena Juhaszova,Steven J. Sollott,Dmitry B. Zorov,Dmitry B. Zorov +12 more
TL;DR: Additional potential mechanisms for which ΔΨm is essential for maintenance of cellular health and viability are proposed and recommendations how to accurately measure ΔΩm in a cell are provided and potential sources of artifacts are discussed.
Journal ArticleDOI
Genomic and biochemical insights into the specificity of ETS transcription factors.
TL;DR: The current knowledge of routes to functional diversity and DNA binding specificity is presented, including divergent properties of the conserved ETS and PNT domains, the involvement of flanking structured and unstructured regions appended to these dynamic domains, posttranslational modifications, and protein partnerships with other DNA-binding proteins and coregulators.
Journal ArticleDOI
Hydrogen sulfide (H2S) metabolism in mitochondria and its regulatory role in energy production
TL;DR: The results suggest that translocation of CSE to mitochondria on specific stress stimulations is a unique mechanism to promote H2S production inside mitochondria, which subsequently sustains mitochondrial ATP production under hypoxic conditions.
Journal ArticleDOI
PNPASE Regulates RNA Import into Mitochondria
Geng Wang,Hsiao-Wen Chen,Yavuz Oktay,Jin Zhang,Eric L. Allen,Geoffrey M. Smith,Kelly C. Fan,Jason S. Hong,Samuel W. French,J. Michael McCaffery,Robert N. Lightowlers,Herbert C. Morse,Carla M. Koehler,Michael A. Teitell +13 more
TL;DR: PNPASE RNA processing and import activities were separable and a mitochondrial RNA targeting signal was isolated that enabled RNA import in a PNPASE-dependent manner, and these data strongly support an unanticipated role for P NPASE in mediating the translocation of RNAs into mitochondria.