Journal ArticleDOI
Analysis and characteristics of multiple types of human 17β-hydroxysteroid dehydrogenase
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TLDR
The different characteristics of the multiple types of human 17beta-HSD are analyzed - types 1, 3, 5 and 7 catalyze the reductive reaction, while types 2, 4 and 8 catalyzeThe oxidative reaction, and it is noteworthy that rat type 6 17 beta- HSD also catalyzes the reaction in the oxidative direction.About:
This article is published in The Journal of Steroid Biochemistry and Molecular Biology.The article was published on 2001-03-01. It has received 259 citations till now. The article focuses on the topics: Hydroxysteroid dehydrogenase & 17beta-hydroxysteroid dehydrogenase.read more
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Overview of Steroidogenic Enzymes in the Pathway from Cholesterol to Active Steroid Hormones
Anita H. Payne,Dale B. Hales +1 more
TL;DR: This review presents a detailed description of the enzymes involved in the biosynthesis of active steroid hormones, with emphasis on the human and mouse enzymes and their expression in gonads, adrenal glands, and placenta.
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Endocrine and intracrine sources of androgens in women: Inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone
Fernand Labrie,Van Luu-The,Claude Labrie,Alain Bélanger,Jacques Simard,Sheng-Xiang Lin,Georges Pelletier +6 more
TL;DR: DHEA has been found to increase bone mineral density and to stimulate vaginal maturation without affecting the endometrium, while improving well-being and libido with no significant side effects and thus minimizing the potential side effects observed with androgens or estrogens administered systemically.
Journal ArticleDOI
The Steroid Hormone Biosynthesis Pathway as a Target for Endocrine-Disrupting Chemicals
TL;DR: This review aims to provide a comprehensive overview of the state of knowledge regarding the mechanisms by which chemicals interfere with the function of steroidogenic enzymes in various tissues and organisms.
Journal ArticleDOI
Is dehydroepiandrosterone a hormone
TL;DR: The new field of intracrinology or local formation of sex steroids from DHEA in target tissues has permitted major advances in the treatment of the two most frequent cancers, namely breast and prostate cancer, while its potential use as a physiological HRT could well provide a physiological balance of androgens and estrogens, thus offering exciting possibilities for women's health at menopause.
Journal ArticleDOI
Obesity and androgens: facts and perspectives
TL;DR: Given the fundamental role of sex hormones in the regulation of body composition, fuel homeostasis, and reproduction in humans, more emphasis should be placed on the potential role of androgen dysregulation in the pathophysiology of different obesity phenotypes and the metabolic syndrome.
References
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Journal ArticleDOI
Endogenous Hormones and Breast Cancer Risk
Leslie Bernstein,Ronald K. Ross +1 more
TL;DR: The lack of total consistency among studies that have assessed estrogen differences, whether in breast cancer patients versus controls or in subgroups of the population characterized by different risk profiles for breast cancer, is not unexpected given the extraordinarily complex methodological issues that must be addressed in these studies.
Journal ArticleDOI
Deletion of steroid 5α-reductase 2 gene in male pseudohermaphroditism
TL;DR: The results verify the existence of at least two 5α-reductases in man and provide insight into a fundamental hormone-mediated event in male sexual differentiation.
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Male pseudohermaphroditism caused by mutations of testicular 17β-hydroxysteroid dehydrogenase 3
Wayne M. Geissler,Daphne L. Davis,Ling Wu,Karen D. Bradshaw,S. Patel,Berenice B. Mendonca,Keith O. Elliston,Jean D. Wilson,David W. Russell,Stefan Andersson +9 more
TL;DR: Four substitution and two splice junction mutations were identified in the 17βHSD3 genes of five unrelated male pseudohermaphrodites that severely compromised the activity of the 17 β–HSD type 3 isozyme.
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Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases.
TL;DR: Both enzymes expressed in COS cells showed similar substrate specificities for naturally occurring steroid hormones, however, synthetic 4-azasteroids demonstrated marked differences in their abilities to inhibit the human and rat steroid 5 alpha-reductases.
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Expression cloning and characterization of human 17 beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity
TL;DR: The data suggest that the 17 beta-HSD type 2 cDNA encodes the microsomal 17 beta -HSD of human placenta, described by several laboratories.