Androgen receptor gene status in plasma DNA associates with worse outcome on enzalutamide or abiraterone for castration-resistant prostate cancer: a multi-institution correlative biomarker study
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...Among these are the presence of neuroendocrine or small-cell characteristics in tumors, sometimes referred to as aggressive variant prostate cancer or neuroendocrine prostate cancer (7–9), the detection of androgen receptor (AR) splice variant 7 in circulating tumor cells (10, 11), and the presence of genomic alterations in TP53, RB1, DNA repair genes, AR, and PI3K pathway genes in circulating tumor DNA (12, 13)....
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...We confirmed a high frequency of genomic alterations in AR, namely amplifications and mutations, consistent with prior reports (5, 12) (Fig....
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Cites result from "Androgen receptor gene status in pl..."
...Nevertheless, AR amplifications were associated with shorter TTP in univariate analyses, with a hazard ratio similar to that identified in a recent study leveraging droplet digital PCR to examine plasma cfDNA AR amplification status in first-line mCRPC (4)....
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"Androgen receptor gene status in pl..." refers background in this paper
...However, the duration of response is variable and overall survival (OS) in unselected patients is modest despite some patients having responses that last several years [1, 2]....
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2,315 citations
"Androgen receptor gene status in pl..." refers background in this paper
...However, the duration of response is variable and overall survival (OS) in unselected patients is modest despite some patients having responses that last several years [1, 2]....
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2,221 citations
"Androgen receptor gene status in pl..." refers background or methods in this paper
...Data emerging after the trial was designed and initiated [7, 19, 20] led the PREMIERE Trial Management Group to additionally prioritize two alternative biomarkers for evaluation, namely AR-V7 detected in CTCs as described previously [19] and plasma AR....
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...Detection of AR splice variants in CTCs is also associated with shorter PFS and OS with enzalutamide or abiraterone [19, 29]....
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2,203 citations
"Androgen receptor gene status in pl..." refers background in this paper
...Greater sensitivity is obtained with higher input DNA [28] although the clinical relevance of rarer mutations is uncertain....
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