Andrographolide engineered gold nanoparticle to overcome drug resistant visceral leishmaniasis.
Suvadra Das,Asim Halder,Saptarshi Mandal,Mohammad A. Jafar Mazumder,Tanmoy Bera,Arup Mukherjee,Partha Roy +6 more
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TLDR
This study aims to arrive at terpenoid andrographolide engineered gold nanoparticle (AGAunps) facile synthesis and its efficacy evaluations against wild and drug resistant VL strains for the first time.Abstract:
Visceral leishmaniasis (VL) is World Health Organization designated most serious leishmaniasis with an annual mortality rate of 50,000. Even after country specific eradication programs, the disease...read more
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Synthesis, characterization, and mechanistic studies of a gold nanoparticle-amphotericin B covalent conjugate with enhanced antileishmanial efficacy and reduced cytotoxicity.
Prakash Kumar,Pushkar Shivam,Saptarshi Mandal,Pragya Prasanna,Saurabh Kumar,Surendra Prasad,Ashish Kumar,Prolay Das,Vahab Ali,Shubhankar K. Singh,Debabrata Mandal +10 more
TL;DR: GNP-based delivery of AmB can be a better, cheaper, and safer alternative than available AmB formulations, and improved antileishmanial efficacy and reduced cytotoxicity.
Journal ArticleDOI
Traditional herbal medicine and nanomedicine: Converging disciplines to improve therapeutic efficacy and human health.
Jing Zhang,Kaili Hu,Liuqing Di,Penglong Wang,Zhidong Liu,Jinming Zhang,Pengfei Yue,Wantong Song,Jingwei Zhang,Tongkai Chen,Zuhua Wang,Yongtai Zhang,Xiaoying Wang,Changyou Zhan,Yung-Chi Cheng,Xiang Li,Quan Li,Jing-Yu Fan,Youqing Shen,Jing-Yan Han,Hongzhi Qiao +20 more
TL;DR: In this article, the authors discuss the overlapping connectivity and relevance of the two fields, including nanoaggregates generated in herbal medicine decoctions, the application of nanotechnology in the delivery and treatment of natural active ingredients, and the influence of physiological regulatory capability of traditional herbal medicine on the in vivo fate of nanoparticles.
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Andrographolide Loaded in Micro- and Nano-Formulations: Improved Bioavailability, Target-Tissue Distribution, and Efficacy of the “King of Bitters”
Marta Casamonti,Laura Risaliti,Giulia Vanti,Vieri Piazzini,Maria Camilla Bergonzi,Anna Rita Bilia +5 more
TL;DR: This review reports on published studies related to microparticles (MPs) and nanoparticles (NPs) loaded with Andrographolide and improved bioavailability, target-tissue distribution, and efficacy of AG loaded in the described drug delivery systems have been reported.
Journal ArticleDOI
Anticancer potential of andrographolide from Andrographis paniculata (Burm.f.) Nees and its mechanisms of action.
Zoya Malik,Rabea Parveen,Bushra Parveen,Sultan Zahiruddin,Mohammad Aasif Khan,Asifa Khan,Sheersh Massey,Sayeed Ahmad,Syed Akhtar Husain +8 more
TL;DR: In this article, the main emphasis was given on the anticancer activity of AG, its proposed mechanisms of action, novel approaches used to improve its biopharmaceutical properties, and its development as an adjuvant therapy for cancer treatment in future.
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Current status of nanoscale drug delivery and the future of nano-vaccine development for leishmaniasis - A review.
Pragya Prasanna,Prakash Kumar,Saurabh Kumar,Vinod Kumar Rajana,Vishnu Kant,Surendra Prasad,Utpal Mohan,Velayutham Ravichandiran,Debabrata Mandal +8 more
TL;DR: In this article, the role of physicochemical properties of a nanoscale delivery system is discussed and different ways of nano-formulation delivery ranging from liposome, niosomes, polymeric, metallic, solid-lipid NPs were updated along with the possible mechanisms of action against the parasite.
References
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Axenically cultured amastigote forms as an in vitro model for investigation of antileishmanial agents.
Denis Sereno,Jean-Loup Lemesre +1 more
TL;DR: Major differences in the drug susceptibilities of parasites at both stages were compared, which show the specific chemosusceptibility of the parasite at the mammalian stage, demonstrate the potential of using cultured amastigotes instead of promastigote in a drug-screening procedure for early detection.
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Generation of Leishmania donovani axenic amastigotes: their growth and biological characteristics
TL;DR: The in vitro culture system described herein provides a useful tool for the generation of large quantities of uniform populations of axenic amastigotes of the L. donovani 1S-CL2D line and should greatly facilitate studies concerning the cell and molecular biology of this parasite developmental stage.
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Drug Resistance in Visceral Leishmaniasis
TL;DR: Overall, the development of antileishmanials has been generally slow; new drugs are needed to control visceral leishmaniasis worldwide and treatment advances should become affordable in the poorest countries, where they are needed most.
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Overview of P-glycoprotein inhibitors: a rational outlook
TL;DR: O objetivo deste presente estudo foi enfatizar a descoberta e desenvolvimento of inibidores mais novos, inertes, atoxicos e mais eficazes, visando especificamente os da P-gp.
Journal ArticleDOI
Biosynthesis of gold nanowires using sugar beet pulp
Laura Castro,M. Luisa Blázquez,Jesús Ángel Muñoz,Felisa González,Camino García-Balboa,Antonio Ballester +5 more
TL;DR: In this paper, sugar beet pulp was used as reductor and capping agent for the synthesis of gold nanowires, which was induced by both basic mediums, due to the competence between biomolecules and hydroxide ions.