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Journal ArticleDOI

Angioblastic meningiomas; clinicopathologic study of 81 cases.

01 May 1970-Journal of Neurosurgery (Journal of Neurosurgery Publishing Group)-Vol. 32, Iss: 5, pp 539-544
About: This article is published in Journal of Neurosurgery.The article was published on 1970-05-01. It has received 133 citations till now.
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Journal ArticleDOI
TL;DR: The close resemblance of hemangiopericytoma to richly vascular forms of fibrous histiocytomas and synovial sarcoma is emphasized, and the morphologic differences from other mesenchymal tumors showing a hemango-like vascular pattern are discussed.

821 citations

Journal ArticleDOI
01 Dec 1975-Cancer
TL;DR: Surgical ablation of hemangiopericytoma of the somatic soft tissues is the only satisfactory method of treatment and local recurrent tumor was experienced by 22 patients after an inadequate local excision.
Abstract: The clinical courses of 60 patients with hemangiopericytoma of the somatic soft tissues are summarized in this retrospective study. The tumors were subjected to a comparative histologic review and classified as benign (12 lesions), borderline malignant (16 lesions), and malignant (32 lesions). Tumors with 1 mitotic figure per 10 high-power field and moderate cellular anaplasia or 1 mitotic figure per 20 high-power fields and moderate cellular anaplasia may be expected to follow a malignant clinical course. Six of the 16 tumors with these microscopic features (borederline lesions) metastasized (37.5%), and 6 exhibited local recurrences after excision. Of the 32 malignant tumors, 25 (78%) metastasized. Twenty-three patients with malignant tumors were followed for more than 5 years or until death from tumor, and only one patient was alive and free of disease. Fifteen of the 23 patients experienced one of more local recurrences. None of the benign tumors metastasized. Surgical ablation of hemangiopericytioma is, in our experience, the only satisfactory method of treatment. Amputation of an extremity need be done only when the location of the lesion precludes a wide local excision. Local recurrent tumor was experienced by 22 patients after an inadequate local excision. Long-term follow-up is recommended because metastasis became apparent in 11% of patients with malignant tumors and 7% with borderline tumors after 5 "disease-free" years.

345 citations

Journal ArticleDOI
TL;DR: Postoperative radiotherapy and/or chemotherapy were significantly associated with increased patient survival time and the tumor was found throughout the entire CNS, usually superficially and closely related to the meninges.

263 citations

Journal ArticleDOI
TL;DR: Among the recurrences, there was a significantly higher degree of cellularity and increased mitotic rate and, probably, of cortical invasion, while nuclear pleomorphism, increased vascularity, and focal necroses showed no definite differences.
Abstract: The incidence of the various histological subtypes of meningiomas was examined in 1238 patients with surgically treated meningiomas, about 80% arising within the cranial cavity. The histological classification used was that of Courville (1950) and Rubinstein (1972), but “angioblastic” meningiomas were segregated into 3 groups: highly vascularized meningiomas, hemangioblastomas, and hemangiopericytomas. Endotheliomatous and transitional forms constituted 85% of the total (71.5% of intracranial tumors), fibroblastic forms 6.6 and 7.5%, respectively, and highly vascularized (endotheliomatous or transitional) meningiomas 5.2% of the intracranial tumors, while true “angioblastic” meningiomas (hemangioblastomas and hemangiopericytomas) amounted to 2.8% of the total (3.1% of the intracranial tumors). 1.2% were “atypical” (so-called malignant) meningiomas; true meningeal sarcomas were excluded.

252 citations

Journal ArticleDOI
TL;DR: For patients with intracranial meningeal hemangiopericytoma, surgical removal followed by external radiotherapy reduced the risk of local recurrence and it was not demonstrated that postoperative radiotherapy protected against neuraxis metastasis.
Abstract: OBJECTIVETo specify that postoperative radiotherapy is useful for preventing local recurrence and neuraxis recurrence of surgically treated meningeal hemangiopericytomas.METHODSWe retrospectively studied 21 patients with meningeal hemangiopericytoma who were followed in our department during a 34-ye

165 citations


Cites background from "Angioblastic meningiomas; clinicopa..."

  • ...The incidence of local recurrence varied from 26 to 80%, depending on the quality of resection, the length of follow-up, and particularly whether postoperative radiotherapy was administered (7, 10, 11, 13, 18, 20)....

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References
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Journal ArticleDOI
TL;DR: HemangIOPERICYTOMA A VASCULAR TUMOR FEATURing ZIMMERMANN's PericYTES is presented, demonstrating the importance of knowing the carrier and removal status of the immune system-derived Tournaisianutra.
Abstract: HEMANGIOPERICYTOMA A VASCULAR TUMOR FEATURING ZIMMERMANN'S PERICYTES ARTHUR STOUT;MARGARET MURRAY; Annals of Surgery

1,331 citations

Journal ArticleDOI
TL;DR: The l i t e r a tu re of ex t r ac ran ia l me ta s t a se s wi th respec t to t y p e s of tumors , age groups, and the i r preference for si tes of me tas tases is reviewed.
Abstract: I N RECENT years m a n y repor t s of i n t r a c ran ia l t u m o r s wi th ex t rac ran ia l me tas tases have a p p e a r e d in the l i t e ra ture . M o s t of these cases have been a d e q u a t e l y d o c u m e n t e d his to logical ly . L e y et al. 52 in a r ecen t r e p o r t have p resen ted a good review of i n t r ac r an i a l t u m o r s wi th me ta s t a se s ou t side the c ran ium. W e were s t i m u l a t e d b y this rev iew to r e p o r t a case of our own occurr ing in a child. L i t t l e emphas i s has been p laced upon the occurrence of ex t racran ia l me ta s t a se s in ch i ldren in p rev ious repor t s t h a t have appea red in t he l i t e ra ture . I n severa l of t he r epor t s va r ious t y p e s of i n t r ac ran i a l t u m o r s have been summar i zed , b u t no a t t e m p t has been m a d e to ana lyze t h e m in g rea te r deta i l . I t is our i n t en t ion to review the l i t e r a tu re of ex t r ac ran ia l me ta s t a se s wi th respec t to t y p e s of tumors , age groups, and the i r preference for si tes of me tas tases .

146 citations