Journal ArticleDOI
Animal models of osteosarcoma
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TLDR
It is anticipated that specific animal models of OS, which most accurately recapitulate the natural disease process in people, will be most useful for advancing the understanding of OS biology, and will facilitate the discovery of disease pathogenesis and the identification of novel therapeutic strategies for managing this lethal metastatic bone sarcoma.Abstract:
Appendicular osteosarcoma (OS) is a primary mesenchymal tumor arising from malignantly transformed osteoblasts. In people, OS is the most common nonhematopoietic, primary skeletal neoplasm diagnosed in adolescents and is the second leading cause of cancer-related fatalities within this age group. Despite aggressive therapeutic management, including limb-sparing surgeries and dose-intense systemic chemotherapies, 30-40% of patients will experience progressive metastatic disease within 5 years of diagnosis. In order to reduce the fatality rate associated with recurrent or metastatic OS, a more thorough understanding of OS pathogenesis and biology is required. Towards this pursuit, comparative animal models of OS have been developed and are actively being studied to expand our fundamental understanding of OS. It is anticipated that specific animal models of OS, which most accurately recapitulate the natural disease process in people, will be most useful for advancing our understanding of OS biology, and will facilitate the discovery of disease pathogenesis and the identification of novel therapeutic strategies for managing this lethal metastatic bone sarcoma.read more
Citations
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Journal ArticleDOI
Molecular genetics of osteosarcoma.
TL;DR: Much work remains in order to complete the understanding of the somatic mutation basis of osteosarcoma, to develop reliable animal models of human disease, and to apply this information to guide new therapeutic approaches for reducing morbidity and mortality of this rare disease.
Journal ArticleDOI
2D MXene-Integrated 3D-Printing Scaffolds for Augmented Osteosarcoma Phototherapy and Accelerated Tissue Reconstruction.
Shanshan Pan,Shanshan Pan,Junhui Yin,Luodan Yu,Changqing Zhang,Yufang Zhu,Yufang Zhu,You-Shui Gao,Yu Chen +8 more
TL;DR: The rational integration of 2D Ti3C2 MXene is demonstrated to efficiently accelerate the in vivo growth of newborn bone tissue of the composite BG scaffolds for achieving concurrent bone‐tumor killing by photonic hyperthermia and bone-tissue regeneration by bioactive scaffolds.
Journal ArticleDOI
Anti-EGFR antibody cetuximab enhances the cytolytic activity of natural killer cells toward osteosarcoma.
Jens H.W. Pahl,S. Eriaty N. Ruslan,Emilie P. Buddingh,Susy J Santos,Karoly Szuhai,Massimo Serra,Hans Gelderblom,Pancras C.W. Hogendoorn,R. Maarten Egeler,M.W. Schilham,Arjan C. Lankester +10 more
TL;DR: The data show that the cytolytic potential of resting NK cells can be potentiated and directed toward osteosarcoma cells with cetuximab, and cetUXimab-mediated immunotherapy may be considered a novel treatment modality in the management of advanced osteosARcoma.
Journal ArticleDOI
Identification of CBX3 and ABCA5 as putative biomarkers for tumor stem cells in osteosarcoma.
Vaibhav Saini,Curtis Hose,Anne Monks,Kunio Nagashima,Bingnan Han,Dianne L. Newton,Angelena Millione,Jalpa Shah,Melinda G. Hollingshead,Karen M. Hite,Mark W. Burkett,Rene Delosh,Thomas Silvers,Dominic A. Scudiero,Robert H. Shoemaker +14 more
TL;DR: Epigenetic, anti-microtubule, and anti-telomerase therapies are identified as candidates for TSC ablation in osteosarcoma in a high-throughput screen.
Journal ArticleDOI
A review of the association between osteosarcoma metastasis and protein translation.
T.S. Osborne,C. Khanna +1 more
TL;DR: A comparative perspective on the problem of OS metastasis that utilizes a cross-species approach may offer unique opportunities to assist in this prioritization and generate new hypotheses related to this important clinical problem.
References
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Journal ArticleDOI
Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms
David Malkin,Frederick P. Li,Frederick P. Li,Louise C. Strong,Joseph F. Fraumeni,Camille E. Nelson,Camille E. Nelson,David H. Kim,Jayne Kassel,Magdalena A. Gryka,Farideh Z. Bischoff,Michael A. Tainsky,Stephen H. Friend +12 more
TL;DR: Germ line p53 mutations have been detected in all five LFS families analyzed and can now be examined in additional families with LFS, and in other cancer patients and families with clinical features that might be attributed to the mutation.
Journal ArticleDOI
One Hundred and Twenty-Seven Cultured Human Tumor Cell Lines Producing Tumors in Nude Mice
TL;DR: C cultured human tumor cell lines produced tumors after sc inoculation of 1-20 million cells into nude mice and the histopathology correlated with the human tumor of origin in all cases.
Book ChapterDOI
The Epidemiology of Osteosarcoma
Giulia Ottaviani,Norman Jaffe +1 more
TL;DR: The overall 5-year survival rate for osteosarcoma is 68%, without significant gender difference, and the age of the patient is correlated with the survival, with the poorest survival among older patients.
Journal ArticleDOI
Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1.
Brian Sauer,Nancy L. Henderson +1 more
TL;DR: The results demonstrate the controlled site- specific synapsis of DNA and recombination by a prokaryotic protein in mammalian cells and suggest that Cre-mediated site-specific recombination may be a useful tool for understanding and modulating genome rearrangements in eukaryotes.
Journal ArticleDOI
Bone sarcomas linked to radiotherapy and chemotherapy in children.
Margaret A. Tucker,Giulio J. D'Angio,Jr Jd Boice,Louise C. Strong,Frederick P. Li,Marilyn Stovall,B. J. Stone,Daniel M. Green,F Lombardi,W Newton +9 more
TL;DR: It is concluded that both radiotherapy and chemotherapy with alkylating agents for childhood cancer increase the subsequent risk of bone cancer.