Antagonism between the Master Regulators of Differentiation Ensures the Discreteness and Robustness of Cell Fates
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TLDR
It is shown that cross-antagonistic mechanisms of actions of MyoD and PPARγ, which are the master regulators of muscle and adipose differentiation, respectively, confer robustness to the integrity of cell differentiation.About:
This article is published in Molecular Cell.The article was published on 2014-05-08 and is currently open access. It has received 18 citations till now. The article focuses on the topics: MyoD & Myogenesis.read more
Citations
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NFIA co-localizes with PPARγ and transcriptionally controls the brown fat gene program.
Yuta Hiraike,Hironori Waki,Jing Yu,Masahiro Nakamura,Kana Miyake,Gaku Nagano,Ryo Nakaki,Ken Suzuki,Hirofumi Kobayashi,Shogo Yamamoto,Wei Sun,Tomohisa Aoyama,Yusuke Hirota,Haruya Ohno,Kenji Oki,Masayasu Yoneda,Andrew P. White,Yu-Hua Tseng,Aaron M. Cypess,Therese Juhlin Larsen,Therese Juhlin Larsen,Naja Z. Jespersen,Camilla Scheele,Shuichi Tsutsumi,Hiroyuki Aburatani,Toshimasa Yamauchi,Takashi Kadowaki +26 more
TL;DR: Results indicate that NFIA activates the cell-type-specific enhancers and facilitates the binding of PPARγ to control the brown fat gene program.
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Fat deposition and accumulation in the damaged and inflamed skeletal muscle: cellular and molecular players.
TL;DR: Findings about muscle resident mesenchymal cell differentiation in adipocytes are summarized and the molecular mediators involved in intramuscular adipose tissue deposition are recapitulates.
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Composite macroH2A/NRF-1 Nucleosomes Suppress Noise and Generate Robustness in Gene Expression.
Matthieu D. Lavigne,Giannis Vatsellas,Alexander Polyzos,Evangelia Mantouvalou,George Sianidis,Ioannis A. Maraziotis,Marios Agelopoulos,Dimitris Thanos +7 more
TL;DR: It is shown that composite nucleosomes containing mH2A and NRF-1 are stably positioned on gene regulatory regions and can buffer transcriptional noise associated with antiviral responses, and the strategic position and stabilization of mH 2A nucleosome in human promoters defines robust gene expression patterns.
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Inherency of Form and Function in Animal Development and Evolution.
TL;DR: Cellular pattern formation, mediated by released morphogens interacting with biochemically responsive and excitable tissues, drew on inherent self-organizing processes in proto-metazoans to transform clusters of holozoan cells into animal embryos and organs.
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Systematic Analysis of Known and Candidate Lysine Demethylases in the Regulation of Myoblast Differentiation
TL;DR: It is found that LSD1, via H3K4me1 demethylation, represses the master regulator of osteoblast differentiation RUNX2 to promote myogenesis in the C2C12 model system, which provides additional mechanisms by which lysine methylation signaling impacts on cell fate decisions.
References
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Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome.
Nathaniel D. Heintzman,Rhona K. Stuart,Gary C. Hon,Yutao Fu,Christina W. Ching,R. David Hawkins,Leah O. Barrera,Sara Van Calcar,Chunxu Qu,Keith A. Ching,Wei Wang,Zhiping Weng,Roland Green,Gregory E. Crawford,Bing Ren +14 more
TL;DR: Insight is given into the connections between chromatin modifications and transcriptional regulatory activity and a novel functional enhancer for the carnitine transporter SLC22A5 (OCTN2) is uncovered, providing a new tool for the functional annotation of the human genome.
Journal ArticleDOI
The protein Id: A negative regulator of helix-loop-helix DNA binding proteins
Robert Benezra,Robert L. Davis,Robert L. Davis,Daniel Lockshon,David L. Turner,Harold Weintraub +5 more
TL;DR: It is proposed that HLH proteins lacking a basic region may negatively regulate other HLHprotein through the formation of nonfunctional heterodimeric complexes.
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PRDM16 controls a brown fat/skeletal muscle switch
Patrick Seale,Bryan C. Bjork,Wenli Yang,Shingo Kajimura,Sherry Chin,Shihuan Kuang,Anthony Scimè,Srikripa Devarakonda,Heather M. Conroe,Hediye Erdjument-Bromage,Paul Tempst,Michael A. Rudnicki,David R. Beier,Bruce M. Spiegelman +13 more
TL;DR: It is shown by in vivo fate mapping that brown, but not white, fat cells arise from precursors that express Myf5, a gene previously thought to be expressed only in the myogenic lineage.
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Transcriptional control of adipocyte formation
TL;DR: A detailed understanding of the processes governing adipose tissue formation will be instrumental in combating the obesity epidemic and constitutes a framework for potential antiobesity strategies.
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Developmental Origin of Fat: Tracking Obesity to Its Source
TL;DR: This Review considers how the developmental origins of fat contribute to its physiological, cellular, and molecular heterogeneity and explores how these factors may play a role in the growing epidemic of obesity.