Journal ArticleDOI
Anti-cancer evaluation of quercetin embedded PLA nanoparticles synthesized by emulsified nanoprecipitation
Sanjeev K. Pandey,Dinesh K. Patel,Ravi Thakur,Durga Prasad Mishra,Pralay Maiti,Chandana Haldar +5 more
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TLDR
The results propose anticancer efficacy of PLA-Qt nanoparticles in terms of its sustained release kinetics revealing novel vehicle for the treatment of cancer.About:
This article is published in International Journal of Biological Macromolecules.The article was published on 2015-04-01. It has received 85 citations till now.read more
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The biological activities, chemical stability, metabolism and delivery systems of quercetin: A review
TL;DR: In this paper, a review of the biological activities, chemical stability, metabolism and toxicity of quercetin and different delivery systems for quercET were discussed, including lipid-based carriers, nanoparticles, inclusion complexes, micelles and conjugates-based encapsulation.
Mathematical modeling of drug delivery from autocatalytically degradable PLGA microspheres — A review
TL;DR: The aim of this review is to highlight mechanistic, mathematical models for drug release from PLGA microspheres that specifically address interactions between phenomena generally attributed to autocatalytic hydrolysis and mass transfer limitation effects.
Journal ArticleDOI
Application of bioactive quercetin in oncotherapy: from nutrition to nanomedicine.
Ju-Suk Nam,Ashish Ranjan Sharma,Lich Thi Nguyen,Chiranjib Chakraborty,Garima Sharma,Garima Sharma,Sang-Soo Lee +6 more
TL;DR: Nanoformulations of quercetin have shown promising results in its uptake by the epithelial system as well as enhanced delivery to the target site, and various desirable measures for its use as a promising onco-therapeutic agent are highlighted.
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A review of nanotechnology-based approaches for breast cancer and triple-negative breast cancer
Vikas Jain,Hitesh Kumar,Haritha V. Anod,Pallavi Chand,N. Vishal Gupta,Surajit Dey,Siddharth S. Kesharwani +6 more
TL;DR: The application of nanomedicine including CRISPR nanoparticle, exosomes for the treatment of BC/TNBC and other molecular targets available such as poly (ADP-ribose) polymerase (PARP), epidermal growth factor receptor (EGFR), Vascular endothelial growth factor (VEGF), etc. for further exploration have been discussed.
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Absorption, distribution, metabolism and excretion of the biomaterials used in Nanocarrier drug delivery systems.
TL;DR: The main analytical techniques used for bioassay of NCs and MDNS and their pharmacokinetics after administration by various routes are reviewed to improve the understanding of MDNS pharmacokinetic behavior and facilitate the development of NC drug delivery systems.
References
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A simple equation for description of solute release I. Fickian and non-fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discs
TL;DR: In this paper, a simple exponential relation Mt/M∞ = ktn is introduced to describe the general solute release behavior of controlled release polymeric devices, where Mt is the fractional release, t is the release time, k is a constant, and n is the diffusional exponent characteristic of the release mechanism.
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The dawning era of polymer therapeutics
TL;DR: The successful clinical application of polymer–protein conjugates, and promising clinical results arising from trials with polymer–anticancer-drug conjugate, bode well for the future design and development of the ever more sophisticated bio-nanotechnologies that are needed to realize the full potential of the post-genomic age.
Journal ArticleDOI
PLGA-based nanoparticles: An overview of biomedical applications
Fabienne Danhier,Eduardo Ansorena,Joana M. Silva,Joana M. Silva,Régis Coco,Aude Le Breton,Véronique Préat +6 more
TL;DR: This review presents why PLGA has been chosen to design nanoparticles as drug delivery systems in various biomedical applications such as vaccination, cancer, inflammation and other diseases.
Book
Computational Handbook of Statistics
James L. Bruning,B. L. Kintz +1 more
TL;DR: In this paper, the authors present an analysis of correlation and correlation coefficients for the Mann-Whitney Test, the Newman-Keuls' and Tukey Mulitple-Comparison Tests, and the Signed-Pairs, Signed-Ranks Test.
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Review of the biology of quercetin and related bioflavonoids
J.V. Formica,W. Regelson +1 more
TL;DR: The role of flavonoids may transcend their presence in food as mentioned in this paper, however, the amount of quercetin that remains biologically available may not be of sufficient concentration, theoretically, to explain the beneficial effects seen with the Mediterranean diet.