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Journal ArticleDOI

Anti-hyper lipidemic activity of methanolic extract of smilax wightii a.dc. in streptozotocin induced male wistar albino rats

30 Dec 2014-Vol. 1, Iss: 2, pp 126-130
TL;DR: The decreased fasting blood glucose levels and lipid lowering properties clearly showed the anti-hyperlipidemic effect of S.wightii.
Abstract: Smilax wightii, an endemic medicinal plant is found in the shola forests at high altitudes in Nilgiri Biosphere Reserve, the Western Ghats, Southern India . The present study, was undertaken to find out the effect of methanolic extract of this plant on the body weight, fasting blood glucose levels and lipid profiles in all the streptozotocin (STZ) induced rats. The extract exerted a significant (P<0.05) effect in the body weight of the experimental animals when compared to the control group. Treatment with the extract and glibenclamide resulted in a significant (P<0.01) reduction in the fasting blood glucose levels in diabetic rats when compared to the normal. The lipid profile such as TC, TG, LDL, and VLDL contents in the serum registered a significant (P<0.01) hike and a decline in the HDL contents in diabetic control group, which were retrieved to near normalcy in the plant extract treated groups. The effect produced by this plant extract was comparable with that of glibenclamide. The decreased fasting blood glucose levels and lipid lowering properties clearly showed the anti-hyperlipidemic effect of S.wightii.

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References
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Journal ArticleDOI
TL;DR: The standard Lipid Research Clinics heparin-Mn2+ (46 mmol/L) method and five improved precipitation methods for quantification of high-density lipoprotein (HDL) cholesterol gave similar results.
Abstract: We compared the standard Lipid Research Clinics heparin-Mn2+ (46 mmol/L) method and five improved precipitation methods for quantification of high-density lipoprotein (HDL) cholesterol. Three of these methods--a dextran sulfate-Mg2+ procedure, reported as a Selected Method, a modified heparin-Mn2+ (92 mmol/L) method, and a modified phosphotungstate-Mg2+ procedure--all gave similar results. Three other methods--the standard heparin-Mn2+ (46 mmol/L) method and two polyethylene glycol methods (75 g/L or pH 10 reagent at 100 g/L final concentrations)--gave slightly higher values for HDL cholesterol. Addition of NaCl or glucose to specimens did not significantly change protein precipitation. In terms of sedimentation effectiveness with hypertriglyceridemic specimens, the methods were ranked in the following order: polyethylene glycol (pH 10, 100 g/L) greater than dextran sulfate-Mg2+ greater than heparin-Mn2+ (92 mmol/L) = polyethylene glycol (75 g/L) greater than phosphotungstate-Mg2+ greater than heparin-Mn2+ (46 mmol/L).

441 citations


"Anti-hyper lipidemic activity of me..." refers methods in this paper

  • ...The rats were sacrificed by decapitation and blood was collected with anti-coagulant and the serum was used to for the estimation of lipid profile-TC-Total cholesterol (Parekh and Jung,197), TG-Triglycerides (Rice, 1970), HDL-High Density Lipoprotein (Warnick et al., 1985), LDL- Low Density Lipoprotein and VLDL -...

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  • ...…by decapitation and blood was collected with anti-coagulant and the serum was used to for the estimation of lipid profile-TC-Total cholesterol (Parekh and Jung,197), TG-Triglycerides (Rice, 1970), HDL-High Density Lipoprotein (Warnick et al., 1985), LDL- Low Density Lipoprotein and VLDL -...

    [...]

  • ...The rats were sacrificed by decapitation and blood was collected with anti-coagulant and the serum was used to for the estimation of lipid profile-TC-Total cholesterol (Parekh and Jung,197), TG-Triglycerides (Rice, 1970), HDL-High Density Lipoprotein (Warnick et al., 1985), LDL- Low Density Lipoprotein and VLDL Very Low Density Lipoprotein (Friedwald et al....

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Journal ArticleDOI
TL;DR: In this paper, different antioxidant tests were employed in order to evaluate the antioxidant activities of water, infusion, ethanol and ethyl acetate extracts of S. excelsa leaves, and the results were compared with natural and synthetic antioxidants.

393 citations

Journal ArticleDOI
TL;DR: The National Cholesterol Education Program recently issued guidelines for treatment of hyperlipidemia in adults including diabetic patients as discussed by the authors, which suggest that certain modifications in these guidelines be made to meet specific needs of diabetic patients.
Abstract: Coronary heart disease is the leading cause of death among patients with non-insulin-dependent diabetes mellitus (NIDDM). NIDDM patients have a high frequency of dyslipidemia, which along with obesity, hypertension, and hyperglycemia may contribute significantly to accelerated coronary atherosclerosis. Because risk factors for coronary heart disease are additive and perhaps multiplicative, even mild degrees of dyslipidemia may enhance coronary heart disease risk. Therefore, therapeutic strategies for management of NIDDM should give equal emphasis to controlling hyperglycemia and dyslipidemia. The National Cholesterol Education Program recently issued guidelines for treatment of hyperlipidemia in adults including diabetic patients. Because of the unique features of diabetic dyslipidemia, however, we suggest that certain modifications in these guidelines be made to meet specific needs of diabetic patients. For example, therapeutic goals for serum cholesterol reduction should be lower in diabetic patients than in nondiabetic subjects. Particular emphasis should be given to weight reduction in NIDDM patients. In some diabetic patients, monounsaturated fatty acids may be a better replacement for saturated fatty acids than carbohydrates. The target for cholesterol lowering should include both very-low-density lipoprotein and low-density lipoprotein (LDL) (non-high-density lipoprotein) rather than LDL alone. To obtain a substantial reduction of cholesterol levels, drug therapy may be required in many patients. However, first-line drugs for nondiabetic patients (nicotinic acid and bile acid sequestrants) may be less desirable in NIDDM patients than hydroxymethylglutaryl coenzyme A (HMG CoA) reductase inhibitors and even fibric acids. In fact, HMG CoA reductase inhibitors may be the drugs of choice for NIDDM patients with elevated LDL cholesterol and borderline hypertriglyceridemia, whereas gemfibrozil appears preferable for NIDDM patients with severe hypertriglyceridemia.

264 citations


"Anti-hyper lipidemic activity of me..." refers background in this paper

  • ...This is generally observed in both type 1 and type 2 diabetes, representing the defect of insulin action in each, either due to inadequate secretion or resistance (Garg and Grundy, 1990)....

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Journal ArticleDOI
01 Sep 1997-Drugs
TL;DR: There is intensive pharmaceutical research to find new drugs able to stimulate insulin secretion, improve insulin action, improve carbohydrate absorption or reduce carbohydrate absorption, alone or in combination with currently available drugs.
Abstract: Non-insulin-dependent diabetes mellitus (NIDDM, type 2 diabetes) is a heterogeneous disease resulting from a dynamic interaction between defects in insulin secretion and insulin action. There are various pharmacological approaches to improving glucose homeostasis, but those currently used in clinical practice either do not succeed in restoring normoglycaemia in most patients or fail after a variable period of time.

195 citations


"Anti-hyper lipidemic activity of me..." refers background in this paper

  • ...Diabetes mellitus is a metabolic disorder, characterized by hyperglycemia together with impaired metabolism of glucose and other energyyielding fuels such as lipids and proteins (Scheen, 1997)....

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01 Jan 2008
TL;DR: This paper focuses mainly on diabetes, plants used as antidiabetics in various traditional medicines, constituents isolated from these plants, various mechanisms through which herbs act against diabetes and few examples of antidiabetic formulations available in the market.
Abstract: Diabetes mellitus is a metabolic disorder in the endocrine system. This dreadful disease is found in all parts of the world and is becoming a serious threat to mankind health. There are lots of chemical agents available to control and to treat diabetic patients, but total recovery from diabetes has not been reported up to this date. Alternative to these synthetic agents, plants provide a potential source of hypoglycemic drugs and are widely used in several traditional systems of medicine to prevent diabetes. Several medicinal plants have been investigated for their beneficial use in different types of diabetes. The effects of these plants may delay the development of diabetic complications and correct the metabolic abnormalities using variety of mechanisms. A considerable number of plants were subjected to clinical trials and were found effective. Moreover, during the past few years many phytoconstituents responsible for antidiabetic effects have been isolated from hypoglycaemic plants. This paper focuses mainly on diabetes, plants used as antidiabetics in various traditional medicines, constituents isolated from these plants, various mechanisms through which herbs act against diabetes and few examples of antidiabetic formulations available in the market.

161 citations


"Anti-hyper lipidemic activity of me..." refers background in this paper

  • ...Decreased physical activity, increasing obesity, stress and changes in food consumption have lead to the cause of diabetes (Jarald et al., 2008)....

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