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Journal ArticleDOI

Antibacterial Activity of Some Nanoparticles Against Some Pathogenic Bacteria That Isolated From Urinary Tract Infections Patient

25 Dec 2019-Journal of drug delivery (Dr. Yashwant Research Labs Pvt. Ltd.)-Vol. 9, Iss: 04, pp 682-685
TL;DR: It is highly recommended using NPs as an economical alternative antibacterial agent, especially in treating ectopic infections but with high concentration since low concentration gives no result without taking the risk of developing resistant bacterial strains as with antibiotics.
Abstract: Nanoparticles include multiple metal oxides such as yttrium, copper, nickel, zinc, iron, and silver that have antimicrobial activity. The present work evaluates the antibacterial activity of some nanoparticles (NPs)against various pathogenic bacterial strains (Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia and Staphylococcus aureus). Antimicrobial activity of NPs was accomplished by the mean of disk diffusion assay using dilutions of (200, 100, 50, 25, and 12.5) and the MIC and MBC of each isolate is determined. NPs shows no antibacterial activity against tested bacteria. It is highly recommended using NPs as an economical alternative antibacterial agent, especially in treating ectopic infections but with high concentration since low concentration gives no result without taking the risk of developing resistant bacterial strains as with antibiotics. How to cite this article: Alnasrawi, T.H., Althabet, Z.A., Salih, G.S. and Al-Jassani, M.J. (2019). Antibacterial Activity of Some Nanoparticles Against Some Pathogenic Bacteria That Isolated From Urinary Tract Infections Patient. International Journal of Drug Delivery Technology, 9(4): 682-685. Source of support: Nil. Conflict of interest: None.

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Journal Article
TL;DR: The results show that zinc oxide, ferric oxide, cupper oxide, silver and yittrium nanoparticles have no anti-fungal activity against tested fungi, while there was different inhibitory effect of antibiotics against the selected fungal strain and the KCA antibiotic appeared with the highest activity while the FLU seemed with the least activity.
Abstract: The present research aim to determine the activity of some antifungal nanoparticles against some molds and yeast strains since Nanoparticles are of wide use in medical field as antimicrobial agents and many promised results show that’s it’s could be suitable for human use with low concentration and these includes multiple metal oxides such as yttrium, copper, nickel, zinc, iron and silver that have antimicrobial activity, in this research we test the antifungal activity of some nanoparticles (NPs) against different strains of mold and yeast. Antimicrobial activity of NPs was accomplished by the mean of disk diffusion assay using dilutions of (200, 100, 50, 25, and 12.5) and the MIC and MFC of each isolate is determined.as well as antibiotic discs were acquired in order to compare its antifungal activity within NPs activity,and those antibiotic include Amikacin (AK30), Cefotaxime(CX30), Ciprofloxacin(CPR5), Gentamicin(CN10). The results show that zinc oxide, ferric oxide, cupper oxide, silver and yittrium nanoparticles have no anti-fungal activity against tested fungi, while there was different inhibitory effect of antibiotics against the selected fungal strain and the KCA antibiotic appeared with the highest activity while the FLU appeared with the least activity.so that its concluded that using NPs as an economic alternative anti-fungal medicine especially in treating ectopic infections must be with high concentration since low concentration give no result without taking risk of developing resistant fungal strains as with antibiotics, as well as to use lab animals for most accurate results.
References
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Journal ArticleDOI
TL;DR: The results indicate that the bactericidal properties of the nanoparticles are size dependent, since the only nanoparticles that present a direct interaction with the bacteria preferentially have a diameter of approximately 1-10 nm.
Abstract: Nanotechnology is expected to open new avenues to fight and prevent disease using atomic scale tailoring of materials. Among the most promising nanomaterials with antibacterial properties are metallic nanoparticles, which exhibit increased chemical activity due to their large surface to volume ratios and crystallographic surface structure. The study of bactericidal nanomaterials is particularly timely considering the recent increase of new resistant strains of bacteria to the most potent antibiotics. This has promoted research in the well known activity of silver ions and silver-based compounds, including silver nanoparticles. The present work studies the effect of silver nanoparticles in the range of 1-100 nm on Gram-negative bacteria using high angle annular dark field (HAADF) scanning transmission electron microscopy (STEM). Our results indicate that the bactericidal properties of the nanoparticles are size dependent, since the only nanoparticles that present a direct interaction with the bacteria preferentially have a diameter of approximately 1-10 nm.

5,609 citations

Journal ArticleDOI
04 Jul 2002-Langmuir
TL;DR: In this paper, reactive magnesium oxide nanoparticles and halogen (Cl2, Br2) adducts of these MgO particles were allowed to contact certain bacteria and spore cells, which yield insight into the biocidal action of these nanoscale materials.
Abstract: Reactive magnesium oxide nanoparticles and halogen (Cl2, Br2) adducts of these MgO particles were allowed to contact certain bacteria and spore cells. Bacteriological test data, atomic force microscopy (AFM) images, and electron microscopy (TEM) images are provided, which yield insight into the biocidal action of these nanoscale materials. The tests show that these materials are very effective against Gram-positive and Gram-negative bacteria as well as spores. ζ-Potential measurements show an attractive interaction between the MgO nanoparticles and bacteria and spore cells, which is confirmed by confocal microscopy images. The AFM studies illustrate considerable changes in the cell membranes upon treatment, resulting in the death of the cells. TEM micrographs confirm these results and supply additional information about the processes inside the cells. Overall, the results presented illustrate that dry powder nanoparticulate formulations as well as water slurries are effective. It is proposed that abrasive...

1,679 citations

Journal ArticleDOI
TL;DR: The synthesis of metallic nanoparticles of silver using a reduction of aqueous Ag(+) ion with the culture supernatants of Klebsiella pneumoniae is reported on and their part in increasing the antimicrobial activities of various antibiotics against Staphylococcus aureus and Escherichia coli is evaluated.

1,192 citations

01 Jan 2010
TL;DR: In this article, the bactericidal effect of colloid silver nanoparticles in the range of 7-50 nm on Gram-negative bacteria and Gram-positive bacteria was studied and the effect of the colloid was evaluated.
Abstract: Nanotechnology is expected to open new avenues to fight and prevent diseases using atomic scale tailoring of materials. Rapid development of bio-nanotechnology and material research leads to a new way in combating bacteria and searching specific properties of nanomaterials. Presently, the increased resistance of bacteria against strong antibiotics offers to nanomaterial research a chance to help alleviating this problem. The present work studies the bactericidal effect of silver nanoparticles in the range of 7-50 nm on Gram-negative bacteria and Gram-positive bacteria. The colloid silver nanoparticles was

1,017 citations