Antibacterial and antifungal activities of fatty acid methyl esters of the blind-your-eye mangrove from India
TL;DR: The fatty acid composition and the antibacterial and antifungal activities of Fatty Acid Methyl Esters (FAME) of the blind-your-eye mangrove plant found along the coastal areas of south India are determined for the first time.
About: This article is published in Brazilian Journal of Microbiology.The article was published on 2007-12-01 and is currently open access. It has received 350 citations till now. The article focuses on the topics: Excoecaria agallocha & Fatty acid.
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TL;DR: It may be concluded from the structural and kinetics studies that the fatty acid, n‐hexadecanoic acid, is an inhibitor of phospholipase A2, hence, an anti‐inflammatory compound, validate the rigorous use of medicated oils rich in n‐ hexadecanoIC acid for the treatment of rheumatic symptoms in the traditional medical system of India, Ayurveda.
Abstract: Ester bond hydrolysis of membrane phospholipids by Phospholipase A2 and consequent release of fatty acids are the initiating steps of inflammation It is proposed in this study that the inhibition of phospholipase A2 is one of the ways to control inflammation Investigations are carried out to identify the mode of inhibition of phospholipase A2 by the n-hexadecanoic acid It may help in designing of specific inhibitors of phospholipase A2 as anti-inflammatory agents The enzyme kinetics study proved that n-hexadecanoic acid inhibits phospholipase A2 in a competitive manner It was identified from the crystal structure at 25 A resolution that the position of n-hexadecanoic acid is in the active site of the phospholipase A2 The binding constant and binding energy have also been calculated using Isothermal Titration Calorimetry Also, the binding energy of n-hexadecanoic acid to phospholipase A2 was calculated by in silico method and compared with known inhibitors It may be concluded from the structural and kinetics studies that the fatty acid, n-hexadecanoic acid, is an inhibitor of phospholipase A2, hence, an anti-inflammatory compound The inferences from the present study validate the rigorous use of medicated oils rich in n-hexadecanoic acid for the treatment of rheumatic symptoms in the traditional medical system of India, Ayurveda
415 citations
Cites background from "Antibacterial and antifungal activi..."
...Many fatty acids are known to have antibacterial and antifungal properties (5)....
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TL;DR: In this paper, the antibacterial activity of Jania rubens, Corallina mediterranea and Pterocladia capillacea were analyzed against human pathogenic bacteria.
124 citations
TL;DR: The present study investigated the feasibility of using Chlorella sorokiniana for CO2 sequestration from industrial flue gas and fatty acid composition in the total lipid was determined to evaluate its suitability for food, feed, and biofuel.
122 citations
TL;DR: Fatty acid methyl esters obtained from vegetable oils of soybean, corn and sunflower indicate the potential of FAMEs as sources for antifungal and antioxidant activity.
Abstract: Fatty acid methyl esters (FAMEs) were obtained from vegetable oils of soybean, corn and sunflower. The current study was focused on evaluating the antifungal activity of FAMEs mainly against Paracoccidioides spp., as well as testing the interaction of these compounds with commercial antifungal drugs and also their antioxidant potential. FAMEs presented small IC50 values (1.86-9.42 μg/mL). All three FAMEs tested showed antifungal activity against isolates of Paracoccidioides spp. with MIC values ranging from 15.6-500 µg/mL. Sunflower FAMEs exhibited antifungal activity that extended also to other genera, with an MIC of 15.6 μg/mL against Candida glabrata and C. krusei and 31.2 μg/mL against C. parapsilosis. FAMEs exhibited a synergetic effect with itraconazole. The antifungal activity of the FAMEs against isolates of Paracoccidioides spp. is likely due to the presence of methyl linoleate, the major compound present in all three FAMEs. The results obtained indicate the potential of FAMEs as sources for antifungal and antioxidant activity.
118 citations
Cites background from "Antibacterial and antifungal activi..."
...parapsilosis and Candida tropicalis (Agoramoorthy et al. 2007)....
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...The FAME extract of Excoecaria agallocha presented antifungal activity against Candida albicans, C. krusei, C. parapsilosis and Candida tropicalis (Agoramoorthy et al. 2007)....
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...However, some works done with methyl esters showed their potential as antifungals (Abdelillah et al. 2013, Agoramoorthy et al. 2007, Chandrasekaran et al. 2011, Golebiowiski et al. 2013, Lima et al. 2011), but these works are still scarce, so it is important to test these compounds....
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TL;DR: In this paper, the authors extracted phytochemical compounds from leaves and stems of C. nutans by microwave-assisted extraction, pressurized microwave assisted extraction (PMAE), supercritical carbon dioxide extraction (SFE), and Soxhlet method to investigate the best technique in terms of yield, extraction time and recovery of bioactive compounds.
95 citations
References
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Book•
09 Jan 2018
TL;DR: Indian medicinal plants/, Indian medicinal plants /, مرکز فناوری اطلاعات و اصاع رسانی, کδاوρزی
Abstract: Indian medicinal plants / , Indian medicinal plants / , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
8,252 citations
TL;DR: The chance to find antimicrobial activities was more apparent in methanol rather than water extracts of the same indigenous plants of Lebanon, with higher antimacterial activities in 20 microl methanolate extract-discs in comparison to that present in the 10 microl discs.
288 citations
"Antibacterial and antifungal activi..." refers background in this paper
...These differences could be due to the nature and level of the antimicrobial agents present in the extracts and their mode of action on different test microorganisms (2)....
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245 citations
"Antibacterial and antifungal activi..." refers background in this paper
...Many fatty acids are known to have antibacterial and antifungal properties (14)....
[...]
Book•
01 Jan 1982
237 citations
"Antibacterial and antifungal activi..." refers background in this paper
...In Sri Lanka, the smoke of the burning wood has been used in the treatment of leprosy, while the root pounded with ginger has been used to reduce swellings of hands and feet (6)....
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TL;DR: Dried roots of Pelargonium reniforme and P. sidoides are examined for antibacterial activity against rapidly growing mycobacteria and unsaturated compounds showed antimycobacterial activity related to their degree of unsaturation, their chain length and the bacterial species tested.
191 citations
"Antibacterial and antifungal activi..." refers background in this paper
...Lauric, palmitic, linolenic, linoleic, oleic, stearic and myristic acids are known to have potential antibacterial and antifungal agents (10, 15)....
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