Journal ArticleDOI
Anticancer agents derived from natural products.
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TLDR
This review will present the anticancer activities, mechanism of action, structure and activity relationships of six important anticancer agents from natural products, that is, taxol, betulinic acid, camptothecin, resveratrol, podophyllotoxin and curcumin.Abstract:
Advances in the prevention and treatment of cancer require the continued development of novel and improved chemopreventive and chemotherapeutic agents. Throughout history, natural products have afforded a rich source of anticancer agents with diverse chemical structures and bioactivities. Recent technological and methodologic advances in structure elucidation, organic synthesis, and biological assay have resulted in the isolation and clinical evaluation of various novel anticancer agents. In this review, we will present the anticancer activities, mechanism of action, structure and activity relationships of six important anticancer agents from natural products, that is, taxol, betulinic acid, camptothecin, resveratrol, podophyllotoxin and curcumin.read more
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Journal ArticleDOI
Resveratrol and cellular mechanisms of cancer prevention
Yogeshwer Shukla,Richa Singh +1 more
TL;DR: A number of preclinical findings from the lab and elsewhere suggest resveratrol to be a promising natural weapon in the war against cancer and advocate that resver atrol holds tremendous potential as an efficient anticancer drug of the future.
Journal ArticleDOI
Bromophenols in Marine Algae and Their Bioactivities
TL;DR: The recent progress of these marine algal biomaterials, with respect to structure, bioactivities, and their potential application as pharmaceuticals are reviewed.
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Medibots: Dual-Action Biogenic Microdaggers for Single-Cell Surgery and Drug Release
TL;DR: These multi-action plant-derived biocompatible "medibots" can play a pivotal role in understanding micromotor interactions at the cellular level, aiming toward the destruction of harmful cells in living systems.
Journal ArticleDOI
Seaweed Phenolics: From Extraction to Applications.
João Cotas,Adriana Leandro,Pedro Monteiro,Diana Pacheco,Artur Figueirinha,Ana M. M. Gonçalves,Ana M. M. Gonçalves,Gabriela Jorge Da Silva,Leonel Pereira +8 more
TL;DR: This review focuses on the extraction, purification, and future applications of seaweedphenolic compounds based on the bioactive properties described in the literature and intends to provide a comprehensive insight into the phenolic compounds in seaweed.
Journal ArticleDOI
Fighting fire with fire: poisonous Chinese herbal medicine for cancer therapy.
TL;DR: To fully exploit the potential of PCHM in cancer therapy, more attentions are advocated to be focused on their safety evaluation and mechanism exploration.
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Journal Article
Anticancer potential of curcumin: preclinical and clinical studies.
TL;DR: Evidence has also been presented to suggest that curcumin can suppress tumor initiation, promotion and metastasis, and Pharmacologically,Curcumin has been found to be safe.
Journal ArticleDOI
Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.
TL;DR: It is proposed that camptothecin blocks the rejoining step of the breakage-reunion reaction of mammalian DNA topoisomerase I, which results in the accumulation of a cleavable complex which resembles the transient intermediate proposed for eukaryotic DNATopoisomersase I.
Journal ArticleDOI
Curcumin as “Curecumin”: From kitchen to clinic
TL;DR: Curcumin, a spice once relegated to the kitchen shelf, has moved into the clinic and may prove to be "Curecumin", a therapeutic agent in wound healing, diabetes, Alzheimer disease, Parkinson disease, cardiovascular disease, pulmonary disease, and arthritis.
Journal ArticleDOI
Potential Therapeutic Effects of Curcumin, the Anti-inflammatory Agent, Against Neurodegenerative, Cardiovascular, Pulmonary, Metabolic, Autoimmune and Neoplastic Diseases
TL;DR: Evidence for the potential role of curcumin in the prevention and treatment of various proinflammatory chronic diseases is provided and its features, combined with the pharmacological safety and negligible cost, renderCurcumin an attractive agent to explore further.
Journal Article
Role of Resveratrol in Prevention and Therapy of Cancer: Preclinical and Clinical Studies
Bharat B. Aggarwal,Anjana Bhardwaj,Rishi S. Aggarwal,Navindra P. Seeram,Shishir Shishodia,Yasunari Takada +5 more
TL;DR: In vivo, resveratrol blocks the multistep process of carcinogenesis at various stages: it blocks carcinogen activation by inhibiting aryl hydrocarbon-induced CYP1A1 expression and activity, and suppresses tumor initiation, promotion and progression.