Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy.
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...However, the existing data are very limited, and are primarily based on a subgroup analysis (n 1⁄4 97) from a single retrospective study with limited control for potential confounders (82)....
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...55 Huang 2020 Yang 2020 Zhou et al Gao 2020 Wang 2020 Wu 2020 Tang 2020 Lippi 2020 Lippi 2020 Lippi 2020...
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...Preliminary results, albeit with small number of events and limited adjustment, may suggest a favorable response from LMWH prophylaxis (82,114)....
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...The JAAM-DIC 2016 score [10] , ISTH overt-DIC score [11] and SIC score [8] were calculated daily until day 7. Scores were considered positive as commonly accepted, if ISTH overt-DIC was 5 points or more, JAAM-DIC score was 4 points or more and if SIC was 4 points or more....
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...[8] suggested that heparin would decrease mortality in severe COVID-19 patients who met the SIC criteria or have markedly elevated D-dimers....
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...Hypercoagulation and MNP activation Importantly, lower platelets counts, increased levels of fibrin degradation products (known as D-dimers) 44 and coagulation abnormalities are being increasingly associated with poor prognosis and could represent a main cause of organ failure and death in patients with severe COVID-19 (ref....
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