Antileishmanial amides and lignans from Piper cubeba and Piper retrofractum
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244 citations
Cites background from "Antileishmanial amides and lignans ..."
...…al., 1990a, 1990b; Bezerra et al., 2005, 2007, 2008a; Tsai et al., 2005; Kong et al., 2008; Lin et al., 2007; Jyothi et al., 2009; Raj et al., 2011; Bokesch et al., 2011; Golovine et al., 2013; Adams et al., 2012), genotoxic (Bezerra et al., 2008b, 2009), antitumor (Bezerra et al., 2006, 2008a;…...
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...…over cancer cells and presents only a weak activity in normal cells (Duh et al., 1990a, 1990b; Bezerra et al., 2005, 2007, 2008a; Kong et al., 2008; Lin et al., 2007; Jyothi et al., 2009; Lee and Mandinova, 2009; Raj et al., 2011; Bokesch et al., 2011; Golovine et al., 2013; Adams et al., 2012)....
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...Additionally, Bokesch et al. (2011) tested the ability of this compound to modulate hypoxia inducible factor-2 (HIF-2) transcription activities in the renal carcinoma cell line, 786-0....
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References
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"Antileishmanial amides and lignans ..." refers background or methods in this paper
...The standards miltefosine and pentamidine were used at reported IC50 values [6, 7]....
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...The mean percentage of posttreatment viable cells was calculated relative to control, and results were expressed as the concentration inhibiting the parasite growth [6]....
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159 citations
"Antileishmanial amides and lignans ..." refers methods in this paper
...Spleen parasitic burden was assessed from Giemsa-stained impression smears [8]....
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116 citations
"Antileishmanial amides and lignans ..." refers background in this paper
...Leishmaniasis patients are highly susceptible to HIV infection, and leishmaniasis accelerates the onset of AIDS by cumulative immunosuppression and by stimulation of the replication of the virus in HIV-infected patients [2]....
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...If untreated, it often leads to death [2]....
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72 citations
"Antileishmanial amides and lignans ..." refers background in this paper
...Compound 4 was identified as pellitorine by comparison of spectral data with literature values [14, 15]....
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