Antimicrobial ionic liquid‐based materials for biomedical applications
Shahid Chamran University of Ahvaz1, Indian Institute of Technology Kharagpur2, University of Barcelona3, King Saud University4, Polytechnic University of Milan5, Damghan University6, Pasteur Institute of Iran7, Zanjan University of Medical Sciences8, Royan Institute9, Istituto Italiano di Tecnologia10, Xi'an Jiaotong University11, Georgia Regents University12
TL;DR: The potential applications of ionic liquids in the biomedical arena, including regenerative medicine, biosensing, and drug/biomolecule delivery, are presented to stimulate the scientific community to further improve the antimicrobial efficacy of ionsic liquids.
Abstract: Excessive and unwarranted administration of antibiotics has invigorated the evolution of multidrug-resistant microbes. There is, therefore, an urgent need for advanced active compounds. Ionic liquids with short-lived ion-pair structures are highly tunable and have diverse applications. Apart from their unique physicochemical features, the newly discovered biological activities of ionic liquids have fascinated biochemists, microbiologists, and medical scientists. In particular, their antimicrobial properties have opened new vistas in overcoming the current challenges associated with combating antibiotic-resistant pathogens. Discussions regarding ionic liquid derivatives in monomeric and polymeric forms with antimicrobial activities are presented here. The antimicrobial mechanism of ionic liquids and parameters that affect their antimicrobial activities, such as chain length, cation/anion type, cation density, and polymerization, are considered. The potential applications of ionic liquids in the biomedical arena, including regenerative medicine, biosensing, and drug/biomolecule delivery, are presented to stimulate the scientific community to further improve the antimicrobial efficacy of ionic liquids.
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TL;DR: The accumulated data on the biological activity of ionic liquids, including their antimicrobial and cytotoxic properties, are discussed in view of possible applications in drug synthesis and drug delivery systems.
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TL;DR: In this review article, a short overview on physicochemical aspects of ionic liquids, such as physical properties of ions, nanoparticles, nanotubes, batteries, spectroscopy, thermodynamics and catalysis of/in ions are given.
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