Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
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...Justifiably, significant attention is being directed toward eukaryotic antimicrobial peptides, which are ubiquitous elements of the innate immune response in a variety of invertebrate, plant, and animal species (64)....
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...acid synthesis, protein synthesis, enzymatic activity, and cell wall synthesis (28) (Fig....
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...In vitro studies have revealed that direct antimicrobial activity is not limited to the previously suggested mechanisms of membrane and/or cell rupture but instead extends to interference with membrane-associated biosynthesis, macromolecular synthesis in the cytoplasm and metabolic function...
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"Antimicrobial peptides: pore former..." refers background in this paper
...This includes the concentrations of antimicrobial peptides at the sites of infection, the role of synergistic substances that might be present in tissues and fluids (for example, the presence of lysozyme, other antimicrobial peptides and proteins, and the absence of divalent cations), the role of inhibiting substances that might be present (for example, physiological concentrations of salts and serous proteins) and the unusual characteristics of bacteria replicating in vivo , particularly those in biofilm...
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