Book ChapterDOI
Antimony and bismuth as antimicrobial agents
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TLDR
In this article, a range of bismuth and antimony complexes in the +-III and +-V oxidation states and evaluated their efficacy toward the treatment of Leishmania or bacteria, including but not limited to: Helicobacter pylori, methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus and Escherichia coli.Abstract:
There is an emerging interest in the application of metal complexes in the treatment of microbial infections and colonization. Their unique modes of action and the difficulty that microbes face in evolving mechanisms for resistance toward metal complexes, makes them attractive. Metal complexes offer a way to incorporate a diverse range of ligands and therefore easily tune physico-chemical properties, which in turn can affect the overall behavior of the complex in a biological system. For more than a decade, we have synthesized and characterized a range of bismuth and antimony complexes in the + III and + V oxidation states and evaluated their efficacy toward the treatment of Leishmania or bacteria, including but not limited to: Helicobacter pylori, methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus and Escherichia coli. In many cases these novel complexes outperform the current medicinal compounds employed. There is still work to be done to understand the relationship between the chemical structure of metal complexes and their corresponding antimicrobial activity. We have compiled recent results in the area of metal complexes against microbes, to uncover some of the trends related to antimicrobial activity.read more
Citations
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Journal ArticleDOI
Medicinal chemistry and biomedical applications of bismuth-based compounds and nanoparticles.
TL;DR: Bismuth is a relatively non-toxic and inexpensive metal with exceptional properties has numerous biomedical applications as discussed by the authors, and it is used extensively as medicines for the treatment of gastrointestinal disorders including dyspepsia, gastric ulcers and H. pylori infections.
Journal ArticleDOI
Antimony(III) dithiocarbamates: Crystal structures, supramolecular aggregations, DNA binding, antioxidant and antileishmanial activities
TL;DR: In this article, the synthesis and characterization of four piperazine-based homoleptic antimony(III) dithiocarbamates (CH2Cl2) was reported.
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Pnictogen-Centered Cascade Exchangers for Thiol-Mediated Uptake: As(III)-, Sb(III)-, and Bi(III)-Expanded Cyclic Disulfides as Inhibitors of Cytosolic Delivery and Viral Entry
Bumhee Lim,Takehiro Kato,Céline Besnard,Amalia I. Poblador Bahamonde,Naomi Sakai,Stefan Matile +5 more
TL;DR: Crystal structures, computational models, and exchange kinetics support that lentivector entry inhibition of the contracteddithiarsinane and the expanded dithiabismepane rings coincides with exchange cascades that occur without the release of the pnictogen relay and benefit from noncovalent pnietogen bonds.
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Materials for Restoring Lost Activity: Old Drugs for New Bugs.
TL;DR: In this article , the authors summarize recent studies that restore antibiotics once thought to be ineffective, but have returned to our armamentarium through innovative, combinatorial efforts, focusing on the mechanisms that allow the synergistic combinations to combat bacteria.
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Bi2O3 nanoparticles exhibit potent broad-spectrum antimicrobial activity and the ability to overcome Ag-, ciprofloxacin- and meropenem-resistance in P. aeruginosa: the next silver bullet of metal antimicrobials?
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References
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Book
CRC Handbook of Chemistry and Physics
TL;DR: CRC handbook of chemistry and physics, CRC Handbook of Chemistry and Physics, CRC handbook as discussed by the authors, CRC Handbook for Chemistry and Physiology, CRC Handbook for Physics,
Journal ArticleDOI
Leishmaniasis Worldwide and Global Estimates of Its Incidence
Jorge Alvar,Iván D. Vélez,Iván D. Vélez,Caryn Bern,Mercè Herrero,Philippe Desjeux,Jorge Cano,Jean Jannin,Margriet den Boer +8 more
TL;DR: Visceral and cutaneous leishmaniasis incidence ranges were estimated by country and epidemiological region based on reported incidence, underreporting rates if available, and the judgment of national and international experts.
Journal ArticleDOI
Pathogenesis of Helicobacter pylori Infection
TL;DR: This review focuses on the microbiological, clinical, immunological, and biochemical aspects of the pathogenesis of H. pylori, which represents a key factor in the etiology of various gastrointestinal diseases.
Journal ArticleDOI
Metallodrugs in Medicinal Inorganic Chemistry
Katja Dralle Mjos,Chris Orvig +1 more
Journal ArticleDOI
Emerging Strategies to Combat ESKAPE Pathogens in the Era of Antimicrobial Resistance: A Review.
TL;DR: The objective of this review is to describe the alternative therapies reported to treat ESKAPE infections, their advantages and limitations, potential application in vivo, and status in clinical trials.
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