Antioxidant activity of sulfated polysaccharide fractions extracted from Laminaria japonica

doi:10.1016/J.IJBIOMAC.2007.10.003

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Antioxidant activity of sulfated polysaccharide fractions extracted from Laminaria japonica

Journal Article•DOI•

Antioxidant activity of sulfated polysaccharide fractions extracted from Laminaria japonica

Jing Wang¹, Quanbin Zhang¹, Zhongshan Zhang¹, Zhien Li¹•Institutions (1)

Chinese Academy of Sciences¹

01 Mar 2008-International Journal of Biological Macromolecules (Elsevier)-Vol. 42, Iss: 2, pp 127-132

TL;DR: Fucoidan, a group of sulfated heteropolysaccharide, was extracted from Laminaria japonica, an important economic alga species in China as mentioned in this paper.

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About: This article is published in International Journal of Biological Macromolecules.The article was published on 2008-03-01. It has received 633 citations till now. The article focuses on the topics: Fucoidan & Fucose.

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Journal Article•DOI•

Bioactive compounds in seaweed: functional food applications and legislation

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Susan Løvstad Holdt, Stefan Kraan

09 Feb 2011-Journal of Applied Phycology

TL;DR: Worldwide research on bioactive compounds in seaweed is reviewed, mainly of nine genera or species of seaweed, which are also available in European temperate Atlantic waters, i.e. Laminaria sp.

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Abstract: Seaweed is more than the wrap that keeps rice together in sushi. Seaweed biomass is already used for a wide range of other products in food, including stabilising agents. Biorefineries with seaweed as feedstock are attracting worldwide interest and include low-volume, high value-added products and vice versa. Scientific research on bioactive compounds in seaweed usually takes place on just a few species and compounds. This paper reviews worldwide research on bioactive compounds, mainly of nine genera or species of seaweed, which are also available in European temperate Atlantic waters, i.e. Laminaria sp., Fucus sp., Ascophyllum nodosum, Chondrus crispus, Porphyra sp., Ulva sp., Sargassum sp., Gracilaria sp. and Palmaria palmata. In addition, Undaria pinnatifida is included in this review as this is globally one of the most commonly produced, investigated and available species. Fewer examples of other species abundant worldwide have also been included. This review will supply fundamental information for biorefineries in Atlantic Europe using seaweed as feedstock. Preliminary selection of one or several candidate seaweed species will be possible based on the summary tables and previous research described in this review. This applies either to the choice of high value-added bioactive products to be exploited in an available species or to the choice of seaweed species when a bioactive compound is desired. Data are presented in tables with species, effect and test organism (if present) with examples of uses to enhance comparisons. In addition, scientific experiments performed on seaweed used as animal feed are presented, and EU, US and Japanese legislation on functional foods is reviewed.

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1,488 citations

Cites background or methods from "Antioxidant activity of sulfated po..."

...Fucan showed low antioxidant activity relative to fucoidan (Rocha de Souza et al. 2007), and as mentioned previously, the ratio of sulphate content/fucose and the molecular weight were effective indicators of the antioxidant activity of the samples (Wang et al. 2008)....
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...…fractions were successfully isolated through anion exchange column chromatography and had their antioxidant activities investigated employing various established in vitro systems, including superoxide and hydroxyl radical scavenging activity, chelating ability and reducing power (Wang et al. 2008)....
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...One of these fractions also showed the strongest ferrous ion-chelating ability at 0.76 mg mL−1 (Wang et al. 2008)....
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...Three sulphated polysaccharide fractions were successfully isolated through anion exchange column chromatography and had their antioxidant activities investigated employing various established in vitro systems, including superoxide and hydroxyl radical scavenging activity, chelating ability and reducing power (Wang et al. 2008)....
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...2007), and as mentioned previously, the ratio of sulphate content/fucose and the molecular weight were effective indicators of the antioxidant activity of the samples (Wang et al. 2008)....
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Journal Article•DOI•

Fucoidan: Structure and Bioactivity

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Bo Li, Fei Lu, Xinjun Wei, Ruixiang Zhao

12 Aug 2008-Molecules

TL;DR: This review summarizes the research progress on the structure and bioactivity of fucoidan and the relationships between structure andBioactivity and several fucoidans’ structures have been solved.

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Abstract: Fucoidan refers to a type of polysaccharide which contains substantial percentages of L-fucose and sulfate ester groups, mainly derived from brown seaweed. For the past decade fucoidan has been extensively studied due to its numerous interesting biological activities. Recently the search for new drugs has raised interest in fucoidans. In the past few years, several fucoidans' structures have been solved, and many aspects of their biological activity have been elucidated. This review summarizes the research progress on the structure and bioactivity of fucoidan and the relationships between structure and bioactivity.

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1,061 citations

Cites background from "Antioxidant activity of sulfated po..."

...The correlation between the sulfate content and scavenging superoxide radical ability was positive, the ratio of sulfate content/fucose was an effective indicator to antioxidant activity of the samples [92]....
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Journal Article•DOI•

Biological activities and potential health benefits of sulfated polysaccharides derived from marine algae

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Isuru Wijesekara¹, Ratih Pangestuti¹, Se-Kwon Kim¹•Institutions (1)

Pukyong National University¹

11 Feb 2011-Carbohydrate Polymers

TL;DR: An overview of biological activities and potential health benefits of SPs derived from marine algae, as well as potential products in nutraceutical, pharmaceutical and cosmeceutical areas are presented.

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781 citations

Journal Article•DOI•

Biological activities of sulfated polysaccharides from tropical seaweeds

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Leandro Silva Costa¹, Gabriel Pereira Fidelis¹, Sara Lima Cordeiro¹, Ruth Medeiros Oliveira¹, Diego Araujo Sabry¹, Rafael Barros Gomes da Câmara¹, Leonardo Thiago Duarte Barreto Nobre¹, Mariana Santana Santos Pereira Costa¹, Jailma Almeida-Lima¹, Eduardo H.C. Farias¹, Edda Lisboa Leite¹, Hugo Alexandre Oliveira Rocha¹ - Show less +8 more•Institutions (1)

Federal University of Rio Grande do Norte¹

01 Jan 2010-Biomedicine & Pharmacotherapy

TL;DR: Several polysaccharides demonstrated promising antioxidant, antiproliferative an/or anticoagulant potential and have been selected for further studies on bioguided fractionation, isolation and characterization of pure poly Saccharides from these species as well as in vivo experiments are needed.

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511 citations

Cites background or methods from "Antioxidant activity of sulfated po..."

...The reducing power of the samples was quantified as described later [23]....
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...Fucoidans (sulfated polysaccharides) from the seaweed Laminaria japonica [23] and ulvans (sulfated polysaccharides) from the seaweed Ulva pertusa [44] have much stronger scavenging activity on superoxide radical than vitamin C....
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...The ferrous ion chelating ability of samples was investigated according to posterior studies [23]....
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Journal Article•DOI•

Potential antioxidant and anticoagulant capacity of low molecular weight fucoidan fractions extracted from Laminaria japonica

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Jing Wang¹, Quanbin Zhang¹, Zhongshan Zhang¹, Houfang Song¹, Pengcheng Li¹ - Show less +1 more•Institutions (1)

Chinese Academy of Sciences¹

01 Jan 2010-International Journal of Biological Macromolecules

TL;DR: The results showed that all fractions possessed considerable antioxidant activities, DF1 was most active, and all samples inhibited coagulant in APTT, TT and PT assays obviously.

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369 citations

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07 May 1976-Analytical Biochemistry

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TL;DR: In this article, a method was developed to determine submicro amounts of sugars and related substances using a phenol-sulfuric acid reaction, which is useful for the determination of the composition of polysaccharides and their methyl derivatives.

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Abstract: Simple sugars, oligosaccharides, polysaccharides, and their derivatives, including the methyl ethers with free or potentially free reducing groups, give an orangeyellow color w-hen treated with phenol and concentrated sulfuric acid. The reaction is sensitive and the color is stable. By use of this phenol-sulfuric acid reaction, a method has been developed to determine submicro amounts of sugars and related substances. In conjunction with paper partition chromatography the method is useful for the determination of the composition of polysaccharides and their methyl derivatives.

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45,381 citations

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T. Bitter¹, Helen Muir¹•Institutions (1)

St Mary's Hospital¹

01 Oct 1962-Analytical Biochemistry

TL;DR: It has been found possible to distinguish betweenHeparin, heparin derivatives, and other polyuronides of connective tissue by comparing the effect of chlorides on the color yield in both procedures by modifying Dische's carbazole reaction for uronic acid in the presence of borate.

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The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen

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Morimitsu Nishikimi¹, N. Appaji Rao¹, Kunio Yagi¹•Institutions (1)

Nagoya University¹

31 Jan 1972-Biochemical and Biophysical Research Communications

TL;DR: The reduction of nitro blue tetrazolium (NitroBT) with NADH mediated by phenazine methosulfate (PMS) under aerobic conditions was inhibited upon addition ofsuperoxide dismutase, indicating the involvement of superoxide aninon radical in the reduction of NitroBT.

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Antioxidant activity of various tea extracts in relation to their antimutagenicity

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Gow-Chin Yen, Hui-Yin Chen

01 Jan 1995-Journal of Agricultural and Food Chemistry

TL;DR: The relationship between antioxidant activity and antimutagenicity of various tea extracts (green tea, pouchong tea, oolong tea and black tea) was investigated in this article, which showed that all tea extracts exhibited markedly antioxidant activity.

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Abstract: The relationship between antioxidant activity and antimutagenicity of various tea extracts (green tea, pouchong tea, oolong tea, and black tea) was investigated. All tea extracts exhibited markedly antioxidant activity and reducing power, especially oolong tea, which inhibited 73.6% peroxidation of linoleic acid. Tea extracts exhibited a 65-75% scavenging effect on superoxide at a dose of 1 mg and 30 - 60% scavenging effect on hydrogen peroxide at a dose of 400 microgram. They scavenged 100% hydroxyl radical at a dosage of 4 mg except the black tea. Tea extracts also showed 50 - 70% scavenging effect on alpha, alpha-diphenyl-beta-picrylhydrazyl radical. The antioxidant activity and the scavenging effects on active oxygen decreased in the order semifermented tea > nonfermented tea > fermented tea. Tea extracts showed strong antimutagenic action against five indirect mutagens, i.e., AFB1, Trp-P-1, Glu-P-1, B[a]P, and IQ, especially oolong and pouchong teas. The antioxidant effect of tea extracts was well correlated to their antimutagenicity in some cases but varied with the mutagen and antioxidative properties.

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2,436 citations