Book ChapterDOI
Antioxidants in the Prevention and Treatment of Cancer
Jawad Alzeer,Rami Arafeh,Kaïs Hussain Al-Gubory +2 more
- pp 493-521
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TLDR
This chapter summarises recent progress on the production and health benefits of antioxidants derived from food and medicinal plants and their use in cancer prevention and treatment and outlines most recent anticancer drugs originally derived from medicinal plants.Abstract:
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are constantly produced in all aerobic organisms, mostly as a consequence of normal cellular aerobic respiration. Many factors outside the body, such as unhealthy diets and behaviours, exposure to environmental pollutants and radiation pollution, also trigger the production of abnormally high concentrations of highly reactive and toxic ROS and NOS in tissues and organs of biological systems. The excessive production of ROS/RNS causes damage to DNA, proteins and lipids and can increase the risk of cancer. Antioxidants maintain redox homeostasis and prevent ROS-/RNS-induced damages that have been associated with cancer development. In the body, antioxidant defence systems include endogenous (enzymatic and non-enzymatic antioxidants) and exogenous antioxidants supplied by plant foods. Plants or parts of plants with medicinal properties are traditionally used in health care and disease prevention and treatment. Plants are considered relatively safe, efficient and inexpensive ways of producing several valuable molecules, including many anticancer drugs. Rational food selection based on therapeutic properties and antioxidant constituents might be a useful strategy for cancer prevention. This chapter summarises recent progress on the production and health benefits of antioxidants derived from food and medicinal plants and their use in cancer prevention and treatment. This chapter also outlines most recent anticancer drugs originally derived from medicinal plants and discusses lead structures isolated from natural product with anticancer potential use as adjuvants in conventional anticancer drugs.read more
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Journal ArticleDOI
In Vitro Pharmaco-Toxicological Characterization of Melissa officinalis Total Extract Using Oral, Pharynx and Colorectal Carcinoma Cell Lines
Kristine Guran,Roxana Buzatu,Iulia Pinzaru,Madalina Boruga,Iasmina Marcovici,Dorina Coricovac,Stefana Avram,Marioara Poenaru,Monica Susan,Razvan Susan,Daniela Radu,Cristina Dehelean +11 more
TL;DR: The findings support the potential benefits of Melissa officinalis leaf total extract as a valuable candidate for the prophylaxis of oral, pharyngeal and colorectal neoplasms.
Journal ArticleDOI
The dialectical law of the unity and struggle of the opposites yang and yin in a living organism (reflections of a doctor)
TL;DR: A manifestation of the effectiveness of the law of negation negation can be called the revival of interest in traditional medicine and the use of natural remedies, in particular medicinal plants, in the treatment of patients.
References
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Journal ArticleDOI
Global cancer statistics
TL;DR: A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.
Journal ArticleDOI
Global cancer statistics, 2012
Lindsey A. Torre,Freddie Bray,Rebecca L. Siegel,Jacques Ferlay,Joannie Lortet-Tieulent,Ahmedin Jemal +5 more
TL;DR: A substantial portion of cancer cases and deaths could be prevented by broadly applying effective prevention measures, such as tobacco control, vaccination, and the use of early detection tests.
Journal ArticleDOI
The ferric reducing ability of plasma (FRAP) as a measure of 'antioxidant power' : the FRAP assay
TL;DR: The FRAP assay offers a putative index of antioxidant, or reducing, potential of biological fluids within the technological reach of every laboratory and researcher interested in oxidative stress and its effects.
Journal ArticleDOI
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
TL;DR: Experimental and computational approaches to estimate solubility and permeability in discovery and development settings are described in this article, where the rule of 5 is used to predict poor absorption or permeability when there are more than 5 H-bond donors, 10 Hbond acceptors, and the calculated Log P (CLogP) is greater than 5 (or MlogP > 415).
Journal ArticleDOI
Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants
TL;DR: The biochemistry of ROS and their production sites, and ROS scavenging antioxidant defense machinery are described, which protects plants against oxidative stress damages.
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