Antiretroviral prophylaxis for HIV prevention in heterosexual men and women.
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Cites background from "Antiretroviral prophylaxis for HIV ..."
...In addition, one clinical trial involving IDUs (77) and one involving heterosexual HIV-discordant couples (75) demonstrated substantial efficacy and safety of daily oral PrEP with TDF alone when combined with repeated condom provision, sexual risk-reduction counseling, and the diagnosis and treatment of STDs....
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...Preexposure Prophylaxis for HIV—Certain large, randomized, placebo-controlled trials examining daily oral antiretroviral preexposure prophylaxis (PrEP) with a fixed-dose combination of tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC) have demonstrated safety (73) and a substantial reduction in the rate of HIV acquisition for MSM (74), HIV-discordant heterosexual couples (75), and heterosexual men and women recruited as individuals (76)....
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...• increased risk for HIV acquisition among HSV-2 seropositive persons who are exposed to HIV (suppressive antiviral therapy does not reduce the increased risk for HIV acquisition associated with HSV-2 infection) (75,347)....
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References
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Additional excerpts
...(%) 150 (9) 84 (5) 134 (8) 106 (7) 122 (8) 103 (7)...
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...18–24 yr 184 (12) 268 (17) 177 (11) 287 (18) 172 (11) 273 (17)...
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